SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gwi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		3 / 3 LEU A  37
PRO A  38
LEU A  82
 None
 0.50A 1hrkA-1gwiA:
undetectable		 1hrkA-1gwiA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 10 LEU A 111
LEU A 213
ILE A 232
THR A 235
THR A 105
 None
 1.42A 1i18A-1gwiA:
0.0
1i18B-1gwiA:
undetectable		 1i18A-1gwiA:
15.09
1i18B-1gwiA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 10 THR A 105
LEU A 111
LEU A 213
ILE A 232
THR A 235
 None
 1.42A 1i18A-1gwiA:
undetectable
1i18B-1gwiA:
undetectable		 1i18A-1gwiA:
15.09
1i18B-1gwiA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		4 / 6 LEU A 321
TYR A 318
ILE A 346
ARG A 295
 None
HEM  A1414 (-3.9A)
None
HEM  A1414 (-2.9A)
 0.86A 2du8A-1gwiA:
undetectable		 2du8A-1gwiA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		4 / 6 LEU A 321
TYR A 318
ILE A 346
ARG A 295
 None
HEM  A1414 (-3.9A)
None
HEM  A1414 (-2.9A)
 0.89A 2du8B-1gwiA:
undetectable		 2du8B-1gwiA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		3 / 3 HIS A 226
ILE A 232
LEU A 103
 None
 0.75A 2kceA-1gwiA:
undetectable		 2kceA-1gwiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		4 / 4 PRO A 330
ASP A 333
ASP A  20
ASP A 336
 None
 1.46A 2nyuA-1gwiA:
undetectable		 2nyuA-1gwiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		3 / 3 LEU A  37
PRO A  38
LEU A  82
 None
 0.47A 2qd5B-1gwiA:
undetectable		 2qd5B-1gwiA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		3 / 3 ALA A 242
THR A 246
CYH A 355
 HEM  A1414 ( 3.7A)
HEM  A1414 (-3.7A)
HEM  A1414 (-2.5A)
 0.51A 3e4eA-1gwiA:
28.0		 3e4eA-1gwiA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		3 / 3 ALA A 242
THR A 246
CYH A 355
 HEM  A1414 ( 3.7A)
HEM  A1414 (-3.7A)
HEM  A1414 (-2.5A)
 0.44A 3e4eB-1gwiA:
28.1		 3e4eB-1gwiA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 12 MET A 160
LEU A 213
ALA A 216
MET A 239
MET A 198
 None
None
None
HEM  A1414 (-4.3A)
None
 1.16A 3erdA-1gwiA:
undetectable		 3erdA-1gwiA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 11 GLY A 322
GLY A 319
THR A  47
ARG A 326
ALA A 327
 None
 1.09A 3g89B-1gwiA:
undetectable		 3g89B-1gwiA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		4 / 6 LEU A 103
HIS A 100
MET A  92
THR A 235
 None
HEM  A1414 (-3.9A)
HEM  A1414 (-3.7A)
None
 1.29A 3thrB-1gwiA:
0.0		 3thrB-1gwiA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 12 ARG A 326
HIS A  49
GLY A 322
ALA A  29
GLY A  30
 None
 1.30A 3v3oB-1gwiA:
0.0		 3v3oB-1gwiA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 12 LEU A 402
LEU A 131
LEU A 134
ALA A 368
ALA A 371
 None
 1.10A 3vw7A-1gwiA:
0.0		 3vw7A-1gwiA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		3 / 3 LEU A  37
PRO A  38
LEU A  82
 None
 0.47A 3w1wB-1gwiA:
undetectable		 3w1wB-1gwiA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 12 LEU A 131
VAL A 141
ILE A 251
PHE A 376
VAL A 404
 None
 1.00A 3w68B-1gwiA:
undetectable		 3w68B-1gwiA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 12 LEU A 406
VAL A 278
SER A 286
PHE A 335
TYR A 373
 None
 1.47A 4amjB-1gwiA:
undetectable		 4amjB-1gwiA:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		6 / 12 PHE A 177
PHE A 178
GLN A 237
ALA A 241
ALA A 242
THR A 246
 None
None
None
None
HEM  A1414 ( 3.7A)
HEM  A1414 (-3.7A)
 1.27A 4j6dA-1gwiA:
52.9		 4j6dA-1gwiA:
51.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		6 / 12 PHE A 177
PHE A 178
GLN A 237
ALA A 241
ALA A 242
THR A 246
 None
None
None
None
HEM  A1414 ( 3.7A)
HEM  A1414 (-3.7A)
 1.26A 4j6dB-1gwiA:
52.9		 4j6dB-1gwiA:
51.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		6 / 12 PHE A 177
PHE A 178
GLN A 237
ALA A 241
ALA A 242
THR A 246
 None
None
None
None
HEM  A1414 ( 3.7A)
HEM  A1414 (-3.7A)
 1.28A 4jbtA-1gwiA:
52.7		 4jbtA-1gwiA:
51.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		4 / 6 GLU A 245
THR A 246
GLN A 396
ASN A 390
 None
HEM  A1414 (-3.7A)
None
None
 1.30A 4pfjB-1gwiA:
undetectable		 4pfjB-1gwiA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		3 / 3 PRO A 152
MET A 153
TYR A 149
 None
 0.90A 4qa2B-1gwiA:
undetectable		 4qa2B-1gwiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 9 SER A 347
ASP A 324
GLY A 322
ALA A 320
VAL A 316
 None
 1.07A 4r1zA-1gwiA:
29.9		 4r1zA-1gwiA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 9 SER A 347
ILE A 346
GLY A 322
ALA A 320
VAL A 316
 None
 1.07A 4r1zA-1gwiA:
29.9		 4r1zA-1gwiA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 12 ASN A 397
PRO A 288
SER A 249
ASP A  20
LEU A  19
 None
HEM  A1414 ( 4.5A)
None
None
None
 0.83A 4xqeA-1gwiA:
undetectable		 4xqeA-1gwiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 12 ASN A 397
PRO A 288
SER A 249
ASP A  20
LEU A  19
 None
HEM  A1414 ( 4.5A)
None
None
None
 0.84A 4xqeB-1gwiA:
undetectable		 4xqeB-1gwiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_A_AG2A502_1
(HOMOSPERMIDINE
SYNTHASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 12 ASN A 397
PRO A 288
SER A 249
ASP A  20
LEU A  19
 None
HEM  A1414 ( 4.5A)
None
None
None
 0.87A 4xrgA-1gwiA:
0.0		 4xrgA-1gwiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_A_AG2A502_1
(HOMOSPERMIDINE
SYNTHASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 12 ASN A 397
VAL A 252
SER A 249
ASP A  20
LEU A  19
 None
 1.37A 4xrgA-1gwiA:
0.0		 4xrgA-1gwiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 12 ASN A 397
PRO A 288
SER A 249
ASP A  20
LEU A  19
 None
HEM  A1414 ( 4.5A)
None
None
None
 0.83A 4xrgB-1gwiA:
undetectable		 4xrgB-1gwiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 12 MET A 160
LEU A 213
ALA A 216
MET A 239
MET A 198
 None
None
None
HEM  A1414 (-4.3A)
None
 1.09A 4zn7A-1gwiA:
0.0		 4zn7A-1gwiA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 11 MET A 160
LEU A 213
ALA A 216
MET A 239
MET A 198
 None
None
None
HEM  A1414 (-4.3A)
None
 1.15A 4zn7B-1gwiA:
2.0		 4zn7B-1gwiA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		3 / 3 PHE A 147
ILE A 251
ASP A 398
 None
 0.76A 5cswB-1gwiA:
undetectable		 5cswB-1gwiA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 12 LEU A  56
LEU A  55
ILE A 315
LEU A 314
HIS A 291
 None
 1.18A 5toaB-1gwiA:
undetectable		 5toaB-1gwiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		4 / 4 LEU A 402
LEU A 388
SER A 259
ALA A 385
 None
None
None
SO4  A1411 (-3.4A)
 1.02A 5uunA-1gwiA:
undetectable		 5uunA-1gwiA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		4 / 6 HIS A 291
ASN A 390
VAL A 393
LEU A  82
 None
 1.07A 5xdhA-1gwiA:
0.0
5xdhC-1gwiA:
0.0		 5xdhA-1gwiA:
11.14
5xdhC-1gwiA:
11.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 7 LEU A  93
ALA A 241
ALA A 242
THR A 246
THR A 289
 HEM  A1414 ( 4.5A)
None
HEM  A1414 ( 3.7A)
HEM  A1414 (-3.7A)
HEM  A1414 ( 4.4A)
 0.58A 6a7jA-1gwiA:
54.4		 6a7jA-1gwiA:
78.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 7 LEU A  93
LEU A 238
ALA A 242
THR A 246
THR A 289
 HEM  A1414 ( 4.5A)
HEM  A1414 ( 4.3A)
HEM  A1414 ( 3.7A)
HEM  A1414 (-3.7A)
HEM  A1414 ( 4.4A)
 0.57A 6a7jA-1gwiA:
54.4		 6a7jA-1gwiA:
78.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		4 / 7 PHE A 177
LEU A 238
ALA A 242
THR A 246
 None
HEM  A1414 ( 4.3A)
HEM  A1414 ( 3.7A)
HEM  A1414 (-3.7A)
 0.59A 6a7jA-1gwiA:
54.4		 6a7jA-1gwiA:
78.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 10 LEU A 151
LEU A 131
ASP A 132
ILE A 123
GLY A 121
 None
 1.09A 6dm0B-1gwiA:
undetectable
6dm0C-1gwiA:
undetectable		 6dm0B-1gwiA:
9.98
6dm0C-1gwiA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1gwi CYTOCHROME P450
154C1
(Streptomyces
coelicolor) 		5 / 11 VAL A 256
SER A 259
THR A 260
LEU A 399
VAL A 404
 None
 1.02A 6dryA-1gwiA:
0.8		 6dryA-1gwiA:
22.10