SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gxk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		3 / 3 GLY A 615
GLY A 578
GLY A 611
 None
 0.38A 3bogC-1gxkA:
0.0		 3bogC-1gxkA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		3 / 3 GLY A 615
GLY A 578
GLY A 611
 None
 0.39A 3bogD-1gxkA:
undetectable		 3bogD-1gxkA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 7 ASN A 549
PRO A 514
ARG A 512
ALA A 555
 None
 1.01A 3twpB-1gxkA:
undetectable		 3twpB-1gxkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 7 ASN A 549
PRO A 514
ARG A 512
ALA A 555
 None
 0.95A 3twpC-1gxkA:
undetectable		 3twpC-1gxkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 6 ARG A 548
ILE A 576
VAL A 608
LEU A 609
 None
 0.92A 4em2A-1gxkA:
undetectable		 4em2A-1gxkA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 613
GLU A 645
GLY A 539
ALA A 542
ILE A 524
 None
 0.96A 4xe5A-1gxkA:
undetectable		 4xe5A-1gxkA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 615
ILE A 576
LEU A 609
GLY A 610
GLY A 611
 None
 0.93A 4yvgA-1gxkA:
undetectable		 4yvgA-1gxkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 9 VAL A 520
LEU A 538
PHE A 614
VAL A 600
ILE A 524
 None
 1.11A 5om2A-1gxkA:
undetectable
5om2B-1gxkA:
undetectable		 5om2A-1gxkA:
18.33
5om2B-1gxkA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 5 LEU A 635
LYS A 632
LEU A 586
GLU A 589
 None
 1.26A 5weaA-1gxkA:
undetectable		 5weaA-1gxkA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 615
ILE A 576
LEU A 609
GLY A 610
GLY A 611
 None
 0.92A 5wyqB-1gxkA:
undetectable		 5wyqB-1gxkA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 615
ILE A 576
LEU A 609
GLY A 610
GLY A 611
 None
 0.89A 5zhmB-1gxkA:
undetectable		 5zhmB-1gxkA:
24.45