SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 VAL A 664
ASN A 663
GLY A 644
LEU A 646
 None
 0.79A 1dzmA-1gxlA:
undetectable		 1dzmA-1gxlA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 ILE A 524
LEU A 609
GLY A 610
PHE A 614
 None
 0.83A 1rtsA-1gxlA:
0.0		 1rtsA-1gxlA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 4 VAL A 503
LEU A 613
ILE A 524
LEU A 523
 None
 1.00A 2byoA-1gxlA:
0.0		 2byoA-1gxlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 7 LYS A 554
ASN A 549
PRO A 572
ALA A 553
 None
 1.50A 2ejgB-1gxlA:
1.3		 2ejgB-1gxlA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 7 ILE A 524
LEU A 609
GLY A 610
PHE A 614
 None
 0.83A 2tsrA-1gxlA:
0.0		 2tsrA-1gxlA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 ILE A 524
LEU A 609
GLY A 610
PHE A 614
 None
 0.82A 2tsrB-1gxlA:
undetectable		 2tsrB-1gxlA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 10 ILE A 524
GLY A 610
PHE A 612
LEU A 537
ARG A 638
 None
 1.33A 3elzB-1gxlA:
undetectable		 3elzB-1gxlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 PHE A 499
ASP A 518
TYR A 496
LEU A 538
 None
 1.06A 3jq7B-1gxlA:
undetectable		 3jq7B-1gxlA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 PHE A 499
ASP A 518
TYR A 496
LEU A 538
 None
 1.13A 3jq7C-1gxlA:
undetectable		 3jq7C-1gxlA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 11 GLY A 578
VAL A 608
GLU A 607
ASP A 577
ILE A 576
 None
 1.21A 3uawA-1gxlA:
undetectable		 3uawA-1gxlA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 5 GLU A 587
GLU A 589
PHE A 592
TYR A 633
 None
 1.36A 4a97J-1gxlA:
0.0		 4a97J-1gxlA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 7 ILE A 524
LEU A 609
GLY A 610
PHE A 614
 None
 0.88A 4iqqA-1gxlA:
undetectable		 4iqqA-1gxlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 ILE A 524
LEU A 609
GLY A 610
PHE A 614
 None
 0.85A 4iqqD-1gxlA:
undetectable		 4iqqD-1gxlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 10 VAL A 503
TYR A 496
VAL A 568
ILE A 570
LEU A 523
 None
 1.46A 4jtqA-1gxlA:
undetectable		 4jtqA-1gxlA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		3 / 3 LEU A 613
LEU A 571
ARG A 650
 None
 0.66A 5hnzB-1gxlA:
undetectable		 5hnzB-1gxlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 ILE A 524
LEU A 609
GLY A 610
PHE A 614
 None
 0.89A 5nooD-1gxlA:
undetectable		 5nooD-1gxlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 7 ILE A 524
LEU A 609
GLY A 610
PHE A 614
 None
 0.84A 5x5qC-1gxlA:
0.0		 5x5qC-1gxlA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 ILE A 524
LEU A 609
GLY A 610
PHE A 614
 None
 0.82A 5x5qD-1gxlA:
0.0		 5x5qD-1gxlA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 ILE A 524
LEU A 609
GLY A 610
PHE A 614
 None
 0.81A 5x5qF-1gxlA:
0.0		 5x5qF-1gxlA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 GLY A 611
ASN A 616
ALA A 596
PHE A 614
 None
 0.98A 5xu8A-1gxlA:
undetectable		 5xu8A-1gxlA:
21.01