SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gxn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 12 ILE A 552
ALA A 555
LEU A 540
LEU A 496
LEU A 331
 None
 0.94A 1fm9A-1gxnA:
undetectable		 1fm9A-1gxnA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 12 GLY A 366
GLN A 361
MET A 397
VAL A 416
ALA A 457
 None
 1.14A 1gs4A-1gxnA:
undetectable		 1gs4A-1gxnA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 12 GLY A 491
LEU A 458
VAL A 539
ALA A 498
PHE A 449
 None
 0.92A 1gseB-1gxnA:
3.0		 1gseB-1gxnA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 11 ALA A 561
ALA A 558
TYR A 648
LEU A 543
GLN A 548
 None
 1.23A 1iiuA-1gxnA:
0.0		 1iiuA-1gxnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		4 / 7 ALA A 447
TYR A 494
SER A 536
ALA A 511
 None
 0.94A 1k5qA-1gxnA:
0.3
1k5qB-1gxnA:
undetectable		 1k5qA-1gxnA:
18.86
1k5qB-1gxnA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 12 ILE A 552
ALA A 555
LEU A 540
LEU A 496
LEU A 331
 None
 0.96A 1k74A-1gxnA:
undetectable		 1k74A-1gxnA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 12 ILE A 552
ALA A 555
LEU A 540
LEU A 496
LEU A 331
 None
 0.94A 1xlsB-1gxnA:
undetectable		 1xlsB-1gxnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 12 ILE A 552
ALA A 555
LEU A 540
LEU A 496
LEU A 331
 None
 0.95A 1xlsC-1gxnA:
undetectable		 1xlsC-1gxnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 12 ILE A 552
ALA A 555
LEU A 540
LEU A 496
LEU A 331
 None
 0.95A 1xlsD-1gxnA:
undetectable		 1xlsD-1gxnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		4 / 8 ILE A 639
ALA A 541
THR A 545
ALA A 339
 None
 0.95A 3hrdA-1gxnA:
undetectable
3hrdB-1gxnA:
0.0		 3hrdA-1gxnA:
23.20
3hrdB-1gxnA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		3 / 3 GLU A 624
GLY A 628
SER A 622
 None
 0.67A 4b53B-1gxnA:
undetectable		 4b53B-1gxnA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		3 / 3 LEU A 433
MET A 454
ASP A 480
 None
 0.70A 4j7xB-1gxnA:
undetectable		 4j7xB-1gxnA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 12 LEU A 439
LEU A 423
TYR A 437
ASP A 389
ASP A 451
 None
 1.42A 4j7xJ-1gxnA:
undetectable		 4j7xJ-1gxnA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		4 / 7 ASN A 603
ARG A 567
GLN A 502
VAL A 505
 None
 1.01A 4mv7A-1gxnA:
undetectable		 4mv7A-1gxnA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 9 ALA A 420
ALA A 419
LEU A 400
LEU A 461
VAL A 460
 None
 1.37A 4or0A-1gxnA:
undetectable		 4or0A-1gxnA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		4 / 8 SER A 444
THR A 387
SER A 385
GLU A 396
 None
 1.40A 4qb9D-1gxnA:
0.0		 4qb9D-1gxnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		3 / 3 VAL A 424
PHE A 476
ARG A 417
 None
 0.93A 4xr4B-1gxnA:
undetectable		 4xr4B-1gxnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		3 / 3 MET A 330
GLN A 548
ARG A 329
 None
 0.97A 5ewzB-1gxnA:
6.8		 5ewzB-1gxnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 12 GLY A 386
GLY A 366
ILE A 388
PHE A 436
LEU A 371
 None
 1.11A 5fa8A-1gxnA:
undetectable		 5fa8A-1gxnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 9 ILE A 639
GLY A 559
THR A 507
TRP A 562
LEU A 531
 None
 1.15A 5fhzB-1gxnA:
undetectable		 5fhzB-1gxnA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 10 ILE A 639
GLY A 559
THR A 507
TRP A 562
LEU A 531
 None
 1.17A 5fhzC-1gxnA:
undetectable		 5fhzC-1gxnA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		3 / 3 MET A 330
GLN A 548
ARG A 329
 None
 0.83A 5m35B-1gxnA:
5.4		 5m35B-1gxnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		3 / 3 MET A 330
GLN A 548
ARG A 329
 None
 0.81A 5m36A-1gxnA:
4.7		 5m36A-1gxnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 12 GLN A 361
GLY A 386
GLU A 384
ASP A 389
PHE A 436
 None
 1.39A 5vlmF-1gxnA:
1.9		 5vlmF-1gxnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		5 / 12 ILE A 552
ALA A 555
LEU A 540
LEU A 496
LEU A 331
 None
 0.91A 5z12B-1gxnA:
undetectable		 5z12B-1gxnA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		3 / 3 MET A 330
GLN A 548
ARG A 329
 None
 0.80A 6fn9A-1gxnA:
2.9		 6fn9A-1gxnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		3 / 3 MET A 330
GLN A 548
ARG A 329
 None
 0.81A 6fnaB-1gxnA:
3.3		 6fnaB-1gxnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1gxn PECTATE LYASE
(Cellvibrio
japonicus) 		3 / 3 MET A 330
GLN A 548
ARG A 329
 None
 0.80A 6fnbA-1gxnA:
3.1		 6fnbA-1gxnA:
21.70