SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 1gxt HYDROGENASE
MATURATION PROTEIN
HYPF
(Escherichia
coli) 		5 / 10 VAL A  46
ILE A  13
LEU A  35
LEU A  61
ALA A  30
 CL  A1092 (-4.9A)
None
None
None
None
 1.00A 2xf3A-1gxtA:
0.0		 2xf3A-1gxtA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1gxt HYDROGENASE
MATURATION PROTEIN
HYPF
(Escherichia
coli) 		4 / 6 VAL A  26
VAL A  20
ILE A  71
ARG A  91
 None
SO4  A1093 (-3.7A)
None
None
 1.03A 3ms9A-1gxtA:
undetectable		 3ms9A-1gxtA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1gxt HYDROGENASE
MATURATION PROTEIN
HYPF
(Escherichia
coli) 		4 / 6 VAL A  26
VAL A  20
ILE A  71
ARG A  91
 None
SO4  A1093 (-3.7A)
None
None
 0.98A 3mssA-1gxtA:
undetectable		 3mssA-1gxtA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1gxt HYDROGENASE
MATURATION PROTEIN
HYPF
(Escherichia
coli) 		4 / 6 VAL A  26
VAL A  20
ILE A  71
ARG A  91
 None
SO4  A1093 (-3.7A)
None
None
 1.02A 3mssC-1gxtA:
undetectable		 3mssC-1gxtA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1gxt HYDROGENASE
MATURATION PROTEIN
HYPF
(Escherichia
coli) 		4 / 6 VAL A  26
VAL A  20
ILE A  71
ARG A  91
 None
SO4  A1093 (-3.7A)
None
None
 1.00A 3pyyA-1gxtA:
undetectable		 3pyyA-1gxtA:
16.96