SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gy8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 8 THR A 368
HIS A 207
HIS A  15
HIS A 272
 None
 0.95A 1ei6D-1gy8A:
0.7		 1ei6D-1gy8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		3 / 3 VAL A 271
ALA A 203
HIS A 221
 None
NAD  A1382 (-3.5A)
UDP  A1383 (-4.2A)
 0.77A 1q23C-1gy8A:
0.0		 1q23C-1gy8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		3 / 3 VAL A 271
ALA A 203
HIS A 221
 None
NAD  A1382 (-3.5A)
UDP  A1383 (-4.2A)
 0.75A 1q23H-1gy8A:
0.0		 1q23H-1gy8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		3 / 3 VAL A 271
ALA A 203
HIS A 221
 None
NAD  A1382 (-3.5A)
UDP  A1383 (-4.2A)
 0.72A 1q23G-1gy8A:
0.0		 1q23G-1gy8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		3 / 3 LEU A 227
HIS A 325
ILE A 234
 None
 0.65A 1s9pB-1gy8A:
0.0		 1s9pB-1gy8A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 6 HIS A 221
LEU A 276
ILE A  12
SER A 140
 UDP  A1383 (-4.2A)
None
NAD  A1382 (-3.8A)
NAD  A1382 (-3.9A)
 1.19A 1sbrA-1gy8A:
undetectable
1sbrB-1gy8A:
0.0		 1sbrA-1gy8A:
19.80
1sbrB-1gy8A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		6 / 12 ALA A   9
GLY A   8
ASP A  75
VAL A  76
ARG A  77
VAL A  96
 NAD  A1382 ( 4.3A)
None
NAD  A1382 (-2.9A)
NAD  A1382 (-3.7A)
NAD  A1382 ( 4.5A)
None
 1.40A 2qe6A-1gy8A:
undetectable		 2qe6A-1gy8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		5 / 12 GLY A   8
ASP A  75
VAL A  76
ARG A  77
VAL A  96
 None
NAD  A1382 (-2.9A)
NAD  A1382 (-3.7A)
NAD  A1382 ( 4.5A)
None
 0.85A 2qe6B-1gy8A:
undetectable		 2qe6B-1gy8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 7 PRO A 111
VAL A 108
SER A 107
GLU A 175
 None
 1.01A 2v2gA-1gy8A:
undetectable
2v2gB-1gy8A:
undetectable		 2v2gA-1gy8A:
20.65
2v2gB-1gy8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 7 PRO A 111
VAL A 108
SER A 107
GLU A 175
 None
 1.02A 2v2gA-1gy8A:
undetectable
2v2gB-1gy8A:
undetectable		 2v2gA-1gy8A:
20.65
2v2gB-1gy8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 7 PRO A 111
VAL A 108
SER A 107
GLU A 175
 None
 1.01A 2v2gC-1gy8A:
undetectable
2v2gD-1gy8A:
undetectable		 2v2gC-1gy8A:
20.65
2v2gD-1gy8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 7 PRO A 111
VAL A 108
SER A 107
GLU A 175
 None
 1.02A 2v2gC-1gy8A:
undetectable
2v2gD-1gy8A:
undetectable		 2v2gC-1gy8A:
20.65
2v2gD-1gy8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 8 PRO A 111
VAL A 108
SER A 107
GLU A 175
 None
 1.00A 2v32A-1gy8A:
undetectable
2v32B-1gy8A:
undetectable		 2v32A-1gy8A:
20.65
2v32B-1gy8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 8 PRO A 111
VAL A 108
SER A 107
GLU A 175
 None
 1.01A 2v32A-1gy8A:
undetectable
2v32B-1gy8A:
undetectable		 2v32A-1gy8A:
20.65
2v32B-1gy8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 8 PRO A 111
VAL A 108
SER A 107
GLU A 175
 None
 0.98A 2v32C-1gy8A:
undetectable
2v32D-1gy8A:
undetectable		 2v32C-1gy8A:
20.65
2v32D-1gy8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 7 PRO A 111
VAL A 108
SER A 107
GLU A 175
 None
 1.03A 2v41E-1gy8A:
undetectable
2v41F-1gy8A:
undetectable		 2v41E-1gy8A:
20.65
2v41F-1gy8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 7 PRO A 111
VAL A 108
SER A 107
GLU A 175
 None
 1.07A 2v41E-1gy8A:
undetectable
2v41F-1gy8A:
undetectable		 2v41E-1gy8A:
20.65
2v41F-1gy8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		3 / 3 PRO A 224
LEU A 227
ARG A 374
 None
 0.87A 3aqiA-1gy8A:
2.1		 3aqiA-1gy8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		3 / 3 PRO A 224
LEU A 227
ARG A 374
 None
 0.75A 3aqiB-1gy8A:
1.9		 3aqiB-1gy8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		5 / 9 ILE A 193
GLY A 195
ILE A 196
ALA A 180
ILE A 122
 None
 1.05A 3el0B-1gy8A:
undetectable		 3el0B-1gy8A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		5 / 12 LEU A  82
PHE A  81
CYH A  99
LEU A 125
ASP A 116
 None
None
NAD  A1382 (-4.5A)
None
None
 1.13A 3ko0A-1gy8A:
undetectable
3ko0B-1gy8A:
undetectable
3ko0C-1gy8A:
undetectable
3ko0D-1gy8A:
undetectable		 3ko0A-1gy8A:
13.92
3ko0B-1gy8A:
13.92
3ko0C-1gy8A:
13.92
3ko0D-1gy8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		5 / 12 ASP A 116
LEU A  82
PHE A  81
CYH A  99
LEU A 125
 None
None
None
NAD  A1382 (-4.5A)
None
 1.11A 3ko0G-1gy8A:
undetectable
3ko0H-1gy8A:
undetectable
3ko0I-1gy8A:
undetectable
3ko0J-1gy8A:
undetectable		 3ko0G-1gy8A:
13.92
3ko0H-1gy8A:
13.92
3ko0I-1gy8A:
13.92
3ko0J-1gy8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		5 / 11 ASP A 116
LEU A 125
LEU A  82
PHE A  81
CYH A  99
 None
None
None
None
NAD  A1382 (-4.5A)
 1.14A 3ko0A-1gy8A:
undetectable
3ko0B-1gy8A:
undetectable
3ko0I-1gy8A:
undetectable
3ko0J-1gy8A:
undetectable		 3ko0A-1gy8A:
13.92
3ko0B-1gy8A:
13.92
3ko0I-1gy8A:
13.92
3ko0J-1gy8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		5 / 12 LEU A  82
PHE A  81
CYH A  99
LEU A 125
ASP A 116
 None
None
NAD  A1382 (-4.5A)
None
None
 1.14A 3ko0M-1gy8A:
undetectable
3ko0N-1gy8A:
undetectable
3ko0O-1gy8A:
undetectable
3ko0P-1gy8A:
undetectable		 3ko0M-1gy8A:
13.92
3ko0N-1gy8A:
13.92
3ko0O-1gy8A:
13.92
3ko0P-1gy8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		3 / 3 VAL A 343
ALA A 345
PHE A 201
 None
 0.78A 4olbA-1gy8A:
2.9		 4olbA-1gy8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 6 ALA A  94
ASP A 135
LEU A 284
SER A  -1
 None
 0.70A 4ot2A-1gy8A:
undetectable		 4ot2A-1gy8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		3 / 3 VAL A 343
ALA A 345
PHE A 201
 None
 0.81A 4w5nA-1gy8A:
3.7		 4w5nA-1gy8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		4 / 6 VAL A  31
LEU A   4
CYH A  99
LEU A 125
 None
None
NAD  A1382 (-4.5A)
None
 1.19A 5hrqB-1gy8A:
undetectable
5hrqI-1gy8A:
undetectable
5hrqJ-1gy8A:
undetectable		 5hrqB-1gy8A:
6.32
5hrqI-1gy8A:
4.22
5hrqJ-1gy8A:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		5 / 12 MET A 129
ALA A  94
LEU A 125
ILE A 122
CYH A 197
 None
 1.40A 5vlmA-1gy8A:
1.6		 5vlmA-1gy8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		5 / 12 MET A 129
ALA A  94
LEU A 125
ILE A 122
CYH A 197
 None
 1.45A 5vlmE-1gy8A:
0.0		 5vlmE-1gy8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		5 / 12 MET A 129
ALA A  94
LEU A 125
ILE A 122
CYH A 197
 None
 1.32A 5vlmG-1gy8A:
0.1		 5vlmG-1gy8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1gy8 UDP-GALACTOSE
4-EPIMERASE
(Trypanosoma
brucei) 		3 / 3 VAL A 267
TYR A 341
GLU A 314
 None
 0.98A 5zmqD-1gy8A:
undetectable
5zmqE-1gy8A:
undetectable		 5zmqD-1gy8A:
20.92
5zmqE-1gy8A:
9.97