SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gy9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		5 / 9 LEU A  60
ARG A  63
PHE A  64
LEU A  23
LEU A  47
 None
 1.29A 2bxeA-1gy9A:
undetectable		 2bxeA-1gy9A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		3 / 3 ASP A 125
ASN A 258
THR A  87
 None
 0.69A 2pymB-1gy9A:
0.0		 2pymB-1gy9A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		5 / 12 TRP A 248
ASP A 101
VAL A 102
PHE A 159
ASN A  95
 None
FE  A 300 (-2.3A)
TAU  A 350 (-3.8A)
TAU  A 350 (-4.3A)
AKG  A 351 ( 3.5A)
 1.08A 2y03A-1gy9A:
undetectable		 2y03A-1gy9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_A_68HA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		5 / 11 TRP A 248
ASP A 101
VAL A 102
PHE A 159
ASN A  95
 None
FE  A 300 (-2.3A)
TAU  A 350 (-3.8A)
TAU  A 350 (-4.3A)
AKG  A 351 ( 3.5A)
 1.08A 2y04A-1gy9A:
undetectable		 2y04A-1gy9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		4 / 7 GLU A 118
ALA A 115
ASN A 243
ALA A 116
 None
 1.10A 2zgwA-1gy9A:
0.0		 2zgwA-1gy9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		4 / 6 GLU A 118
ALA A 115
ASN A 243
ALA A 116
 None
 1.14A 2zgwB-1gy9A:
undetectable		 2zgwB-1gy9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		4 / 7 ALA A 134
ALA A 133
ALA A 137
GLN A 235
 None
 0.76A 3a2qA-1gy9A:
0.0		 3a2qA-1gy9A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		5 / 12 TRP A 248
ASP A 101
VAL A 102
PHE A 159
ASN A  95
 None
FE  A 300 (-2.3A)
TAU  A 350 (-3.8A)
TAU  A 350 (-4.3A)
AKG  A 351 ( 3.5A)
 1.17A 3d4sA-1gy9A:
undetectable		 3d4sA-1gy9A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		4 / 5 GLN A  43
THR A 129
THR A 103
HIS A 153
 None
 1.49A 3glqA-1gy9A:
undetectable		 3glqA-1gy9A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		4 / 5 GLN A  43
THR A 129
THR A 103
HIS A 153
 None
 1.49A 3n58A-1gy9A:
undetectable		 3n58A-1gy9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		4 / 7 ILE A  18
LEU A  35
VAL A 252
SER A 130
 None
 0.93A 3r9vA-1gy9A:
0.0
3r9vB-1gy9A:
0.0		 3r9vA-1gy9A:
20.20
3r9vB-1gy9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		5 / 12 ALA A 246
PHE A  46
LEU A  10
THR A 253
VAL A 236
 None
 1.08A 3rukA-1gy9A:
undetectable		 3rukA-1gy9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		3 / 3 TRP A 128
VAL A 252
TRP A 248
 None
 1.48A 3zq8A-1gy9A:
undetectable
3zq8B-1gy9A:
undetectable		 3zq8A-1gy9A:
7.43
3zq8B-1gy9A:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		3 / 3 TRP A 248
VAL A 252
TRP A 128
 None
 1.31A 3zq8A-1gy9A:
undetectable
3zq8B-1gy9A:
undetectable		 3zq8A-1gy9A:
7.43
3zq8B-1gy9A:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		5 / 12 TRP A 248
ASP A 101
VAL A 102
PHE A 159
ASN A  95
 None
FE  A 300 (-2.3A)
TAU  A 350 (-3.8A)
TAU  A 350 (-4.3A)
AKG  A 351 ( 3.5A)
 1.03A 4amjA-1gy9A:
undetectable		 4amjA-1gy9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		5 / 11 GLN A  50
ALA A  21
LEU A   5
PHE A  64
ILE A 113
 None
 1.41A 4claA-1gy9A:
0.0		 4claA-1gy9A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		5 / 11 PHE A  46
ASP A 249
TRP A 128
ILE A 247
ALA A 246
 None
 1.04A 5lg3A-1gy9A:
0.0		 5lg3A-1gy9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		4 / 9 PHE A  46
ASP A 249
TRP A 128
ILE A 247
 None
 1.02A 5lg3I-1gy9A:
undetectable		 5lg3I-1gy9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		5 / 9 ALA A 246
ILE A 247
ILE A  18
ALA A  38
LEU A  35
 None
 1.12A 5mvmA-1gy9A:
0.0
5mvmE-1gy9A:
0.0		 5mvmA-1gy9A:
15.30
5mvmE-1gy9A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		4 / 5 HIS A  99
ASP A 101
HIS A 255
ARG A 270
 FE  A 300 (-3.4A)
FE  A 300 (-2.3A)
FE  A 300 ( 3.3A)
TAU  A 350 ( 2.9A)
 0.37A 6dchA-1gy9A:
29.7		 6dchA-1gy9A:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		5 / 12 TRP A 248
ASP A 101
VAL A 102
PHE A 159
ASN A  95
 None
FE  A 300 (-2.3A)
TAU  A 350 (-3.8A)
TAU  A 350 (-4.3A)
AKG  A 351 ( 3.5A)
 1.22A 6h7jA-1gy9A:
undetectable		 6h7jA-1gy9A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		5 / 12 TRP A 248
ASP A 101
VAL A 102
PHE A 159
ASN A  95
 None
FE  A 300 (-2.3A)
TAU  A 350 (-3.8A)
TAU  A 350 (-4.3A)
AKG  A 351 ( 3.5A)
 1.20A 6h7mA-1gy9A:
undetectable		 6h7mA-1gy9A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE
(Escherichia
coli) 		5 / 12 TRP A 248
ASP A 101
VAL A 102
PHE A 159
ASN A  95
 None
FE  A 300 (-2.3A)
TAU  A 350 (-3.8A)
TAU  A 350 (-4.3A)
AKG  A 351 ( 3.5A)
 1.20A 6h7mB-1gy9A:
undetectable		 6h7mB-1gy9A:
17.21