SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gyn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		4 / 4 VAL A 282
PHE A 222
SER A 277
VAL A 278
 None
 1.18A 1e7cA-1gynA:
0.0		 1e7cA-1gynA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 12 LEU A 116
LEU A 115
ILE A  83
GLY A 121
LEU A 123
 None
 0.92A 2j7xA-1gynA:
undetectable		 2j7xA-1gynA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 12 THR A 108
ALA A  90
LEU A 137
ALA A 125
GLY A  80
 None
 1.01A 2ve3A-1gynA:
0.0		 2ve3A-1gynA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 12 LEU A 116
LEU A 115
ILE A  83
GLY A 121
LEU A 123
 None
 0.96A 2yjaB-1gynA:
undetectable		 2yjaB-1gynA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		4 / 7 ILE A 119
LEU A 122
MET A 169
THR A 170
 None
 0.99A 3ag4N-1gynA:
0.0
3ag4W-1gynA:
0.1		 3ag4N-1gynA:
20.57
3ag4W-1gynA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 10 GLY A  64
ALA A  65
ILE A  87
GLY A  89
ILE A  42
 None
 1.06A 3el9B-1gynA:
undetectable		 3el9B-1gynA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 12 LEU A 116
LEU A 115
ILE A  83
GLY A 121
LEU A 123
 None
 0.87A 3q95A-1gynA:
undetectable		 3q95A-1gynA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 12 PHE A  60
GLY A  89
GLY A  64
ALA A  65
ALA A  81
 None
 1.12A 3sudB-1gynA:
undetectable		 3sudB-1gynA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		4 / 6 ILE A 119
LEU A 122
MET A 169
THR A 170
 None
 1.01A 3wg7A-1gynA:
2.8
3wg7J-1gynA:
0.1		 3wg7A-1gynA:
20.57
3wg7J-1gynA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		4 / 6 HIS A 110
GLU A 147
ASP A 144
SER A 146
 CD  A 401 (-3.5A)
None
CD  A 402 (-2.3A)
CD  A 402 (-3.1A)
 1.42A 4apjA-1gynA:
undetectable
4apjP-1gynA:
undetectable		 4apjA-1gynA:
21.20
4apjP-1gynA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 12 LEU A 116
LEU A 115
ILE A  83
GLY A 121
LEU A 123
 None
 0.89A 4j26A-1gynA:
undetectable		 4j26A-1gynA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		4 / 4 ILE A 287
ASN A 286
ILE A  57
VAL A  56
 None
 1.30A 4uy87-1gynA:
undetectable		 4uy87-1gynA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		3 / 3 PHE A 216
ILE A 218
ASP A 144
 None
None
CD  A 402 (-2.3A)
 0.58A 5cswA-1gynA:
undetectable		 5cswA-1gynA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		3 / 3 PHE A 216
ILE A 218
ASP A 144
 None
None
CD  A 402 (-2.3A)
 0.54A 5cswB-1gynA:
undetectable		 5cswB-1gynA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 11 LEU A 116
LEU A 115
ILE A  83
GLY A 121
LEU A 123
 None
 0.93A 5dxbB-1gynA:
undetectable		 5dxbB-1gynA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 12 LEU A 116
LEU A 115
ILE A  83
GLY A 121
LEU A 123
 None
 0.95A 5gtrA-1gynA:
undetectable		 5gtrA-1gynA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		4 / 6 LEU A 123
CYH A 157
HIS A 141
LEU A 171
 None
 1.11A 5hrqD-1gynA:
undetectable
5hrqG-1gynA:
undetectable
5hrqH-1gynA:
undetectable		 5hrqD-1gynA:
6.55
5hrqG-1gynA:
4.36
5hrqH-1gynA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 12 HIS A 107
VAL A  11
ALA A  33
GLY A  89
ALA A  90
 None
 1.11A 5kirB-1gynA:
0.0		 5kirB-1gynA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 8 VAL A  93
ILE A  42
VAL A 102
HIS A  99
VAL A 104
 None
 1.14A 5l94A-1gynA:
undetectable		 5l94A-1gynA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 12 ILE A  57
VAL A 262
VAL A 282
ILE A  12
VAL A  20
 None
 1.06A 5n0sA-1gynA:
undetectable		 5n0sA-1gynA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 12 ILE A  57
VAL A 262
VAL A 282
ILE A  12
VAL A  20
 None
 1.07A 5n0sB-1gynA:
undetectable		 5n0sB-1gynA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		5 / 12 ILE A 143
SER A 165
PHE A 216
HIS A 141
LEU A 123
 None
 1.36A 6chgC-1gynA:
undetectable		 6chgC-1gynA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		4 / 5 PHE A  21
VAL A 102
PRO A  32
VAL A 283
 None
 1.43A 6ekzA-1gynA:
0.0		 6ekzA-1gynA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		4 / 8 VAL A  77
GLY A  63
SER A  66
ALA A  69
 None
 0.67A 6hu9H-1gynA:
undetectable
6hu9e-1gynA:
undetectable		 6hu9H-1gynA:
12.07
6hu9e-1gynA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II
(Escherichia
coli) 		4 / 6 ILE A 119
LEU A 122
MET A 169
THR A 170
 None
 0.98A 6nmfN-1gynA:
undetectable
6nmfW-1gynA:
0.1		 6nmfN-1gynA:
20.57
6nmfW-1gynA:
11.35