SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		3 / 3 ASP A 345
ARG A 342
ILE A 288
 None
 0.87A 1a4gB-1gyqA:
undetectable		 1a4gB-1gyqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		5 / 12 ILE A 185
ALA A 264
LYS A 180
ILE A 277
THR A 265
 None
 1.18A 1ddsA-1gyqA:
undetectable		 1ddsA-1gyqA:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		4 / 7 ASN A 335
TYR A 339
ASN A 169
TYR A 333
 NBD  A 361 (-3.9A)
NBD  A 361 (-3.6A)
None
None
 0.88A 1dssG-1gyqA:
49.0		 1dssG-1gyqA:
54.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		7 / 7 SER A 165
THR A 167
ASN A 169
CYH A 170
TYR A 333
ASN A 335
TYR A 339
 None
None
None
None
None
NBD  A 361 (-3.9A)
NBD  A 361 (-3.6A)
 0.19A 1dssG-1gyqA:
49.0		 1dssG-1gyqA:
54.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		4 / 8 ASN A 335
TYR A 339
ASN A 169
TYR A 333
 NBD  A 361 (-3.9A)
NBD  A 361 (-3.6A)
None
None
 0.88A 1dssR-1gyqA:
49.2		 1dssR-1gyqA:
54.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		8 / 8 SER A 165
THR A 167
ASN A 169
CYH A 170
HIS A 194
TYR A 333
ASN A 335
TYR A 339
 None
None
None
None
None
None
NBD  A 361 (-3.9A)
NBD  A 361 (-3.6A)
 0.29A 1dssR-1gyqA:
49.2		 1dssR-1gyqA:
54.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		5 / 12 LEU A  97
GLY A 122
LEU A 113
GLY A 112
LYS A  89
 None
None
NBD  A 361 (-4.7A)
NBD  A 361 (-3.6A)
None
 1.17A 1y4lA-1gyqA:
undetectable		 1y4lA-1gyqA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		3 / 3 GLY A 213
ASP A 210
SER A 207
 None
 0.59A 2qhfA-1gyqA:
1.4		 2qhfA-1gyqA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		3 / 3 MET A 146
VAL A 161
GLU A 152
 None
 0.90A 3c6gA-1gyqA:
0.0		 3c6gA-1gyqA:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		4 / 8 ASN A 335
TYR A 339
ASN A 169
TYR A 333
 NBD  A 361 (-3.9A)
NBD  A 361 (-3.6A)
None
None
 0.91A 3dmtC-1gyqA:
55.9		 3dmtC-1gyqA:
84.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		8 / 8 SER A 165
THR A 167
ASN A 169
CYH A 170
HIS A 194
TYR A 333
ASN A 335
TYR A 339
 None
None
None
None
None
None
NBD  A 361 (-3.9A)
NBD  A 361 (-3.6A)
 0.27A 3dmtC-1gyqA:
55.9		 3dmtC-1gyqA:
84.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		3 / 3 ASN A  81
HIS A  83
VAL A  33
 None
 0.47A 3elzB-1gyqA:
0.0		 3elzB-1gyqA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		5 / 12 VAL A 309
GLY A 290
LEU A 289
ARG A 342
ILE A 302
 None
 1.16A 3ijdB-1gyqA:
0.0		 3ijdB-1gyqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		3 / 3 GLY A 188
ILE A 174
VAL A 175
 None
 0.39A 3nv6A-1gyqA:
undetectable		 3nv6A-1gyqA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		4 / 4 ILE A   3
VAL A 107
VAL A 347
ARG A 348
 None
 1.36A 4m6tA-1gyqA:
0.0		 4m6tA-1gyqA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		5 / 11 SER A 165
LEU A 171
PRO A 173
VAL A 145
THR A 143
 None
 1.22A 4uuuB-1gyqA:
undetectable		 4uuuB-1gyqA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		5 / 8 ALA A 281
ALA A 280
ILE A 277
ALA A 172
LEU A 178
 None
 1.32A 4v1fA-1gyqA:
undetectable
4v1fB-1gyqA:
undetectable		 4v1fA-1gyqA:
14.76
4v1fB-1gyqA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		3 / 3 THR A 168
ALA A 164
ASN A 169
 None
 0.59A 5ersA-1gyqA:
2.6		 5ersA-1gyqA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		4 / 6 THR A 265
GLY A 184
PHE A 183
ILE A 174
 None
 0.93A 5kmfA-1gyqA:
0.0
5kmfC-1gyqA:
0.0		 5kmfA-1gyqA:
20.73
5kmfC-1gyqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)
(Leishmania
mexicana) 		4 / 7 THR A 168
LEU A 346
VAL A  17
GLN A  24
 None
 1.13A 5tudA-1gyqA:
undetectable		 5tudA-1gyqA:
23.35