SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 4 THR A 393
LEU A 395
LEU A 422
GLN A 427
 None
 1.23A 1fbmA-1gytA:
0.0		 1fbmA-1gytA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 ALA A 472
LEU A 488
ALA A 487
LEU A 466
ILE A 468
 None
 1.20A 1g5yB-1gytA:
0.0		 1g5yB-1gytA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 8 VAL A 374
VAL A 358
TYR A 236
VAL A 362
 None
 0.87A 1igxA-1gytA:
0.0		 1igxA-1gytA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 6 ALA A 409
LEU A 402
LEU A 466
LEU A 267
 None
 0.90A 1mt1D-1gytA:
0.0
1mt1E-1gytA:
0.0		 1mt1D-1gytA:
12.03
1mt1E-1gytA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 SER A   9
VAL A  20
ILE A  73
ILE A  43
GLN A  34
 None
 1.02A 1qhsA-1gytA:
undetectable		 1qhsA-1gytA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 SER A   9
VAL A  20
ILE A  73
ILE A  43
GLN A  34
 None
 1.02A 1qhyA-1gytA:
undetectable		 1qhyA-1gytA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 LEU A 359
ALA A 299
VAL A 358
LEU A 272
ASP A 467
 None
None
None
ZN  A 601 ( 4.7A)
None
 1.21A 1rlbE-1gytA:
undetectable		 1rlbE-1gytA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 7 ASP A 415
ALA A 487
GLY A 302
THR A 482
 None
 0.84A 1t7iB-1gytA:
undetectable		 1t7iB-1gytA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 TYR A 202
VAL A 300
ALA A 299
LEU A 190
MET A 294
 None
 1.30A 1udtA-1gytA:
undetectable		 1udtA-1gytA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 8 ARG A 356
ALA A 321
GLY A 296
LEU A 454
 CO3  A 603 (-3.9A)
None
None
None
 0.74A 2o4nB-1gytA:
undetectable		 2o4nB-1gytA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 11 SER A  39
LEU A  60
ALA A  45
GLU A  11
LEU A  28
 None
 1.42A 2v0mA-1gytA:
undetectable		 2v0mA-1gytA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 8 LEU A 488
LEU A 489
LEU A 402
ALA A 397
 None
 0.85A 2vcvF-1gytA:
undetectable		 2vcvF-1gytA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 MET A 290
GLU A 354
ASN A 439
 None
ZN  A 602 (-2.3A)
None
 1.11A 3a27A-1gytA:
undetectable		 3a27A-1gytA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 GLY A 322
GLY A 269
GLY A 271
 None
 0.17A 3bogC-1gytA:
undetectable		 3bogC-1gytA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 LEU A 203
GLY A 269
GLY A 271
MET A 294
LEU A 489
 None
 1.14A 3dh0B-1gytA:
undetectable		 3dh0B-1gytA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 ILE A  31
GLU A  11
SER A  44
ILE A  43
LEU A  75
 None
 1.29A 3ia4B-1gytA:
undetectable		 3ia4B-1gytA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 GLU A 370
ARG A 221
VAL A 251
ILE A 317
ASN A 315
 None
 1.20A 3jayA-1gytA:
0.0		 3jayA-1gytA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 6 ILE A  18
VAL A  20
LEU A  75
LEU A  62
 None
 0.89A 3kp6A-1gytA:
0.3
3kp6B-1gytA:
0.0		 3kp6A-1gytA:
15.34
3kp6B-1gytA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 11 ALA A 200
ASN A 245
GLY A 224
ILE A 223
VAL A 358
 None
 0.92A 3lzvB-1gytA:
undetectable		 3lzvB-1gytA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 6 GLU A 225
GLY A 224
LEU A 237
GLU A 230
 None
 0.96A 3w9tB-1gytA:
0.0		 3w9tB-1gytA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 6 GLU A 225
GLY A 224
LEU A 237
GLU A 230
 None
 0.95A 3w9tE-1gytA:
0.0		 3w9tE-1gytA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 6 GLU A 225
GLY A 224
LEU A 237
GLU A 230
 None
 0.95A 3w9tF-1gytA:
0.0		 3w9tF-1gytA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 PHE A 159
PHE A 111
LEU A  35
ILE A  73
ALA A 108
 None
 1.35A 4a83A-1gytA:
0.0		 4a83A-1gytA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 ARG A  48
LEU A  47
GLY A  50
ALA A 108
MET A 157
 None
 1.33A 4fe1A-1gytA:
0.0
4fe1J-1gytA:
0.0		 4fe1A-1gytA:
22.02
4fe1J-1gytA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 8 GLY A 183
TYR A 123
VAL A 130
GLU A 131
 None
 0.89A 4fgzA-1gytA:
undetectable		 4fgzA-1gytA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 10 ALA A 200
ASN A 245
GLY A 224
ILE A 223
VAL A 358
 None
 1.00A 4j5jB-1gytA:
undetectable		 4j5jB-1gytA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 9 THR A 379
ILE A 468
GLY A 269
LEU A 203
LEU A 190
 None
 1.27A 4ze0A-1gytA:
0.0		 4ze0A-1gytA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 ASN A 350
MET A 396
ALA A 450
ASP A 293
GLU A 354
 None
None
None
ZN  A 601 (-2.2A)
ZN  A 602 (-2.3A)
 1.29A 4zjoA-1gytA:
undetectable		 4zjoA-1gytA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 TRP A 418
ILE A 407
SER A 410
 None
 0.87A 5gqbA-1gytA:
undetectable		 5gqbA-1gytA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 GLU A 114
LEU A  52
LEU A  28
LEU A  75
THR A  59
 None
 1.11A 5hnwB-1gytA:
undetectable		 5hnwB-1gytA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 GLU A 114
LEU A  52
LEU A  28
LEU A  75
THR A  59
 None
 1.12A 5hnyB-1gytA:
undetectable		 5hnyB-1gytA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 LEU A 388
LEU A 420
ARG A 443
 None
 0.59A 5hnzB-1gytA:
undetectable		 5hnzB-1gytA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 LEU A 488
LEU A 493
ASN A 495
ILE A 375
ILE A 265
 None
 1.06A 5itzB-1gytA:
2.0		 5itzB-1gytA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 ARG A 263
ILE A 317
PHE A 369
 None
 0.73A 5kirA-1gytA:
0.0		 5kirA-1gytA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 LEU A 489
ALA A 490
LEU A 267
 None
 0.45A 5uunB-1gytA:
undetectable		 5uunB-1gytA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 7 GLY A 483
LEU A 406
ILE A 180
GLY A 183
ILE A 265
 None
 1.27A 5vkqA-1gytA:
undetectable
5vkqB-1gytA:
undetectable		 5vkqA-1gytA:
15.43
5vkqB-1gytA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 8 GLY A 483
LEU A 406
ILE A 180
GLY A 183
ILE A 265
 None
 1.24A 5vkqB-1gytA:
undetectable
5vkqC-1gytA:
undetectable		 5vkqB-1gytA:
15.43
5vkqC-1gytA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		3 / 3 THR A 393
THR A 471
ARG A 484
 None
 0.50A 5wm2A-1gytA:
undetectable		 5wm2A-1gytA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 9 VAL A  19
LEU A 112
GLY A  54
THR A  59
CYH A  78
 None
 1.30A 6czmD-1gytA:
0.0
6czmE-1gytA:
0.0		 6czmD-1gytA:
21.06
6czmE-1gytA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		5 / 12 LEU A 190
GLY A 269
GLY A 271
ILE A 468
VAL A 300
 None
 0.98A 6ecxA-1gytA:
undetectable		 6ecxA-1gytA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 1gyt CYTOSOL
AMINOPEPTIDASE
(Escherichia
coli) 		4 / 6 GLN A 491
GLU A 405
ALA A 408
GLN A 412
 None
 1.49A 6f6jC-1gytA:
0.1
6f6jD-1gytA:
0.1		 6f6jC-1gytA:
22.82
6f6jD-1gytA:
22.82