SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gyu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1gyu ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		5 / 12 ILE A 735
ALA A 709
PRO A 755
PHE A 758
LEU A 760
 None
 0.97A 1cd2A-1gyuA:
undetectable		 1cd2A-1gyuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1gyu ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		5 / 12 ILE A 735
ALA A 709
PHE A 816
PRO A 755
LEU A 760
 None
 1.23A 1dlsA-1gyuA:
undetectable		 1dlsA-1gyuA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 1gyu ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		5 / 12 ILE A 735
ALA A 709
PHE A 816
PRO A 755
LEU A 760
 None
 1.29A 1u70A-1gyuA:
undetectable		 1u70A-1gyuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1gyu ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		4 / 7 ILE A 782
PHE A 816
LEU A 792
ILE A 796
 None
 0.90A 1yc2E-1gyuA:
undetectable		 1yc2E-1gyuA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1gyu ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		5 / 12 ILE A 735
ALA A 709
PRO A 755
PHE A 758
LEU A 760
 None
 0.95A 2cd2A-1gyuA:
undetectable		 2cd2A-1gyuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1gyu ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		5 / 12 LEU A 798
LEU A 760
MET A 794
PHE A 816
PHE A 721
 None
 1.15A 2ygpA-1gyuA:
4.3		 2ygpA-1gyuA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1gyu ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		5 / 7 THR A 720
GLU A 722
VAL A 732
THR A 734
VAL A 781
 None
 0.74A 3em0B-1gyuA:
2.2		 3em0B-1gyuA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 1gyu ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		4 / 4 ILE A 782
PHE A 719
ILE A 735
THR A 731
 None
 1.14A 3ia4A-1gyuA:
undetectable		 3ia4A-1gyuA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1gyu ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		5 / 9 ARG A 793
GLN A 791
PHE A 816
GLU A 812
ILE A 707
 None
 1.47A 5i73A-1gyuA:
undetectable		 5i73A-1gyuA:
13.77