SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gyv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1gyv ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		5 / 12 ILE A 735
ALA A 709
PRO A 755
PHE A 758
LEU A 760
 None
 1.06A 1cd2A-1gyvA:
undetectable		 1cd2A-1gyvA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 1gyv ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		5 / 12 ILE A 735
ALA A 709
PHE A 816
PRO A 755
LEU A 760
 None
 1.36A 1u70A-1gyvA:
undetectable		 1u70A-1gyvA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1gyv ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		5 / 12 ILE A 735
ALA A 709
PRO A 755
PHE A 758
LEU A 760
 None
 1.01A 2cd2A-1gyvA:
undetectable		 2cd2A-1gyvA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1gyv ADAPTER-RELATED
PROTEIN COMPLEX 1
GAMMA 1 SUBUNIT
(Mus
musculus) 		4 / 7 THR A 720
VAL A 732
THR A 734
VAL A 781
 None
 0.59A 3em0B-1gyvA:
2.2		 3em0B-1gyvA:
22.38