SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gz0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 LEU A 164
LEU A  85
LEU A 151
PRO A 150
VAL A 121
 None
 1.19A 1hrkA-1gz0A:
3.8		 1hrkA-1gz0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 LEU A 164
LEU A  85
PRO A 150
ARG A  78
VAL A 121
 None
 1.24A 1hrkB-1gz0A:
2.1		 1hrkB-1gz0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		3 / 3 ASN A 108
ALA A 132
ASN A 135
 None
 0.78A 1n4fA-1gz0A:
0.0		 1n4fA-1gz0A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		4 / 8 ALA A 123
ASP A 101
ILE A  99
ILE A 171
 None
 0.86A 1rg9B-1gz0A:
0.0		 1rg9B-1gz0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		4 / 8 ALA A 123
ASP A 101
ILE A  99
ILE A 171
 None
 0.88A 1rg9A-1gz0A:
undetectable		 1rg9A-1gz0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		4 / 8 ALA A 123
ASP A 101
ILE A  99
ILE A 171
 None
 0.87A 1rg9D-1gz0A:
undetectable		 1rg9D-1gz0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		4 / 8 ALA A 123
ASP A 101
ILE A  99
ILE A 171
 None
 0.87A 1rg9C-1gz0A:
0.0		 1rg9C-1gz0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		7 / 12 GLY A 196
GLY A 201
ILE A 216
MET A 218
LEU A 225
VAL A 227
ALA A 230
 None
 0.78A 1v2xA-1gz0A:
19.0		 1v2xA-1gz0A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 GLY A 199
ILE A 216
MET A 218
SER A 224
LEU A 225
 None
 1.01A 1v2xA-1gz0A:
19.0		 1v2xA-1gz0A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		7 / 12 GLY A 199
ILE A 216
MET A 218
SER A 224
LEU A 225
VAL A 227
ALA A 230
 None
 0.70A 1v2xA-1gz0A:
19.0		 1v2xA-1gz0A:
25.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 11 GLY A 199
MET A 218
SER A 224
LEU A 225
ALA A 230
 None
 0.89A 1x7pA-1gz0A:
23.2
1x7pB-1gz0A:
23.5		 1x7pA-1gz0A:
31.44
1x7pB-1gz0A:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 11 ILE A 216
MET A 218
SER A 224
LEU A 225
ALA A 230
 None
 0.83A 1x7pA-1gz0A:
23.2
1x7pB-1gz0A:
23.5		 1x7pA-1gz0A:
31.44
1x7pB-1gz0A:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 11 THR A 174
GLY A 196
GLY A 201
MET A 218
LEU A 225
ALA A 230
 None
 0.48A 1x7pA-1gz0A:
23.2
1x7pB-1gz0A:
23.5		 1x7pA-1gz0A:
31.44
1x7pB-1gz0A:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 10 GLY A 196
ILE A 216
MET A 218
LEU A 225
ALA A 230
 None
 0.78A 1x7pA-1gz0A:
23.2
1x7pB-1gz0A:
23.5		 1x7pA-1gz0A:
31.44
1x7pB-1gz0A:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 10 GLY A 199
ILE A 216
MET A 218
LEU A 225
ALA A 230
 None
 0.64A 1x7pA-1gz0A:
23.2
1x7pB-1gz0A:
23.5		 1x7pA-1gz0A:
31.44
1x7pB-1gz0A:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 10 THR A 174
GLY A 196
GLY A 201
MET A 218
LEU A 225
ALA A 230
 None
 0.52A 1x7pA-1gz0A:
23.2
1x7pB-1gz0A:
23.5		 1x7pA-1gz0A:
31.44
1x7pB-1gz0A:
31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 ALA A  72
LEU A  39
ILE A   8
SER A  62
LEU A  43
 None
 0.86A 1xdkB-1gz0A:
undetectable		 1xdkB-1gz0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 ALA A  72
LEU A  39
ILE A   8
SER A  62
LEU A  43
 None
 0.86A 1xdkF-1gz0A:
0.0		 1xdkF-1gz0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 LEU A  98
GLN A 241
SER A 185
LEU A 182
MET A 195
 None
 1.37A 2aa5B-1gz0A:
undetectable		 2aa5B-1gz0A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 LEU A 164
LEU A  85
LEU A 151
PRO A 150
VAL A 121
 None
 1.22A 2hrcA-1gz0A:
1.3		 2hrcA-1gz0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 11 LEU A 164
LEU A  85
LEU A 151
PRO A 150
VAL A 121
 None
 1.39A 2po5B-1gz0A:
3.8		 2po5B-1gz0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 LEU A 164
LEU A  85
LEU A 151
PRO A 150
VAL A 121
 None
 1.26A 2qd4A-1gz0A:
undetectable		 2qd4A-1gz0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 LEU A 164
LEU A  85
LEU A 151
PRO A 150
VAL A 121
 None
 1.31A 2qd4B-1gz0A:
3.8		 2qd4B-1gz0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		4 / 4 LYS A 139
LEU A 134
ALA A 142
LEU A 109
 None
 1.18A 2roxA-1gz0A:
0.0		 2roxA-1gz0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		3 / 3 ARG A 162
ASP A 101
ASN A 156
 None
 0.84A 2zzmA-1gz0A:
undetectable		 2zzmA-1gz0A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 11 GLY A 196
GLY A 201
ILE A 216
LEU A 225
VAL A 227
ALA A 230
 None
 0.86A 3dcmX-1gz0A:
12.7		 3dcmX-1gz0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 11 GLY A 199
ILE A 216
LEU A 225
VAL A 227
ALA A 230
 None
 0.64A 3dcmX-1gz0A:
12.7		 3dcmX-1gz0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		7 / 11 THR A 174
GLY A 196
GLY A 201
ILE A 233
LEU A 225
VAL A 227
ALA A 230
 None
 1.48A 3dcmX-1gz0A:
12.7		 3dcmX-1gz0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 11 GLY A 196
GLY A 102
ASP A 101
ARG A 207
ALA A 175
GLU A 177
 None
 1.15A 3g88A-1gz0A:
2.2		 3g88A-1gz0A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 11 GLY A 196
GLY A 102
ASP A 101
ARG A 207
ALA A 175
GLU A 177
 None
 1.17A 3g88B-1gz0A:
2.3		 3g88B-1gz0A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 12 GLY A 196
GLY A 102
ASP A 101
ARG A 207
ALA A 175
GLU A 177
 None
 1.19A 3g89A-1gz0A:
2.1		 3g89A-1gz0A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 11 GLY A 196
GLY A 102
ASP A 101
ARG A 207
ALA A 175
GLU A 177
 None
 1.14A 3g89B-1gz0A:
2.2		 3g89B-1gz0A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 12 GLY A 196
GLY A 102
ASP A 101
ARG A 207
ALA A 175
GLU A 177
 None
 1.19A 3g8bA-1gz0A:
2.1		 3g8bA-1gz0A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 12 GLY A 196
GLY A 102
ASP A 101
ARG A 207
ALA A 175
GLU A 177
 None
 1.11A 3g8bB-1gz0A:
1.6		 3g8bB-1gz0A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 11 GLY A 196
ILE A 216
MET A 218
LEU A 225
VAL A 227
 None
 0.90A 3gyqB-1gz0A:
21.7		 3gyqB-1gz0A:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 11 ILE A 216
MET A 218
SER A 224
LEU A 225
VAL A 227
 None
 0.54A 3gyqB-1gz0A:
21.7		 3gyqB-1gz0A:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 8 ILE A 233
SER A 115
SER A 228
GLY A 232
ASN A 226
 None
 1.21A 3lslA-1gz0A:
undetectable
3lslD-1gz0A:
undetectable		 3lslA-1gz0A:
19.16
3lslD-1gz0A:
19.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		7 / 12 ASN A 108
GLY A 196
GLY A 201
ILE A 216
MET A 218
ASN A 226
VAL A 227
 None
 0.80A 3nk7A-1gz0A:
21.9		 3nk7A-1gz0A:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 12 ASN A 108
GLY A 196
GLY A 201
ILE A 233
ASN A 226
VAL A 227
 None
 1.16A 3nk7A-1gz0A:
21.9		 3nk7A-1gz0A:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 12 ASN A 108
GLY A 199
ILE A 216
MET A 218
SER A 224
VAL A 227
 None
 1.04A 3nk7A-1gz0A:
21.9		 3nk7A-1gz0A:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		7 / 12 ASN A 108
GLY A 201
ILE A 216
MET A 218
SER A 224
ASN A 226
VAL A 227
 None
 1.05A 3nk7A-1gz0A:
21.9		 3nk7A-1gz0A:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		7 / 12 ASN A 108
GLY A 196
GLY A 201
ILE A 216
MET A 218
LEU A 225
VAL A 227
 None
 0.70A 3nk7B-1gz0A:
22.0		 3nk7B-1gz0A:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 12 ASN A 108
GLY A 199
ILE A 216
MET A 218
SER A 224
LEU A 225
 None
 1.23A 3nk7B-1gz0A:
22.0		 3nk7B-1gz0A:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 12 ASN A 108
ILE A 216
MET A 218
SER A 224
LEU A 225
VAL A 227
 None
 0.72A 3nk7B-1gz0A:
22.0		 3nk7B-1gz0A:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 12 GLY A 199
ILE A 216
MET A 218
SER A 224
LEU A 225
VAL A 227
 None
 0.70A 3nk7B-1gz0A:
22.0		 3nk7B-1gz0A:
30.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		3 / 3 PHE A  26
LYS A  61
SER A  62
 None
 1.23A 3tyeB-1gz0A:
undetectable		 3tyeB-1gz0A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 LEU A  14
LEU A  36
LEU A  39
ILE A  40
LEU A  58
 None
 1.06A 4dm8B-1gz0A:
undetectable		 4dm8B-1gz0A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		3 / 3 ASP A 101
ARG A 153
THR A 206
 None
 0.84A 4i13A-1gz0A:
undetectable		 4i13A-1gz0A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		4 / 8 ALA A 123
ASP A 101
ILE A  99
ILE A 171
 None
 0.88A 4kttB-1gz0A:
0.0		 4kttB-1gz0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		4 / 8 ALA A 123
ASP A 101
ILE A  99
ILE A 171
 None
 0.87A 4kttD-1gz0A:
undetectable		 4kttD-1gz0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		3 / 3 ASP A 101
ARG A 153
THR A 206
 None
 0.85A 4p3rA-1gz0A:
undetectable		 4p3rA-1gz0A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 GLY A   7
ALA A  72
PHE A  22
VAL A  25
ARG A  31
 None
 1.01A 4u8yB-1gz0A:
0.0		 4u8yB-1gz0A:
13.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 9 GLY A 196
ILE A 216
MET A 218
SER A 224
LEU A 225
VAL A 227
 None
 0.95A 4x3mB-1gz0A:
9.2		 4x3mB-1gz0A:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 9 GLY A 201
ILE A 216
MET A 218
SER A 224
LEU A 225
 None
 0.96A 4x3mB-1gz0A:
9.2		 4x3mB-1gz0A:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 10 GLY A 173
VAL A 172
GLU A 212
HIS A 180
SER A 185
 None
 1.29A 4yb6A-1gz0A:
undetectable
4yb6E-1gz0A:
undetectable		 4yb6A-1gz0A:
23.96
4yb6E-1gz0A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 10 GLY A 173
VAL A 172
GLU A 212
SER A 185
LEU A 182
 None
 1.27A 4yb6A-1gz0A:
undetectable
4yb6E-1gz0A:
undetectable		 4yb6A-1gz0A:
23.96
4yb6E-1gz0A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 10 GLY A 173
VAL A 172
GLU A 212
HIS A 180
SER A 185
 None
 1.28A 4yb6B-1gz0A:
undetectable
4yb6C-1gz0A:
undetectable		 4yb6B-1gz0A:
23.96
4yb6C-1gz0A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 10 GLY A 173
VAL A 172
GLU A 212
SER A 185
LEU A 182
 None
 1.26A 4yb6B-1gz0A:
undetectable
4yb6C-1gz0A:
undetectable		 4yb6B-1gz0A:
23.96
4yb6C-1gz0A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 10 HIS A 180
SER A 185
GLY A 173
VAL A 172
GLU A 212
 None
 1.29A 4yb6B-1gz0A:
undetectable
4yb6F-1gz0A:
0.0		 4yb6B-1gz0A:
23.96
4yb6F-1gz0A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 10 SER A 185
LEU A 182
GLY A 173
VAL A 172
GLU A 212
 None
 1.26A 4yb6B-1gz0A:
undetectable
4yb6F-1gz0A:
0.0		 4yb6B-1gz0A:
23.96
4yb6F-1gz0A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		3 / 3 ASN A 156
ALA A 158
ARG A 162
 None
 0.48A 5cvtB-1gz0A:
4.5		 5cvtB-1gz0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 GLY A 199
ILE A 216
SER A 224
LEU A 225
ALA A 230
 None
 0.66A 5l0zA-1gz0A:
23.7		 5l0zA-1gz0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		6 / 12 THR A 174
GLY A 196
GLY A 201
ILE A 216
LEU A 225
ALA A 230
 None
 0.66A 5l0zA-1gz0A:
23.7		 5l0zA-1gz0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 10 GLY A 199
ILE A 216
SER A 224
LEU A 225
ALA A 230
 None
 0.90A 5l0zB-1gz0A:
8.1		 5l0zB-1gz0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 10 THR A 174
GLY A 196
GLY A 201
LEU A 225
ALA A 230
 None
 0.47A 5l0zB-1gz0A:
8.1		 5l0zB-1gz0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 10 THR A 174
GLY A 196
ILE A 216
LEU A 225
ALA A 230
 None
 0.64A 5l0zB-1gz0A:
8.1		 5l0zB-1gz0A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 VAL A 103
ASP A 105
ARG A 114
ARG A 153
LEU A 134
 None
 1.18A 5nd7B-1gz0A:
2.1		 5nd7B-1gz0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 7 GLY A 196
GLY A 201
SER A 215
LEU A 225
ALA A 230
 None
 0.90A 5o96C-1gz0A:
12.6		 5o96C-1gz0A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		4 / 7 GLY A 199
SER A 215
LEU A 225
ALA A 230
 None
 0.75A 5o96C-1gz0A:
12.6		 5o96C-1gz0A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		5 / 12 ALA A 119
SER A 115
LEU A  98
PHE A  96
LEU A 191
 None
 1.13A 5w7pA-1gz0A:
1.5		 5w7pA-1gz0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH
(Escherichia
coli) 		4 / 4 LYS A 139
LEU A 134
ALA A 142
LEU A 109
 None
 1.07A 6gnrB-1gz0A:
undetectable		 6gnrB-1gz0A:
20.48