SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 THR A 113
THR A 115
PRO A 109
 None
 0.83A 1a7yB-1gz4A:
undetectable		 1a7yB-1gz4A:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 4 LYS A 496
LEU A 492
ALA A 495
LEU A 322
 None
 1.42A 1f86A-1gz4A:
0.0		 1f86A-1gz4A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 4 LYS A 496
LEU A 492
ALA A 495
LEU A 322
 None
 1.45A 1f86B-1gz4A:
0.0		 1f86B-1gz4A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 ILE A  83
GLY A  87
HIS A  69
MET A  75
LEU A 107
 None
 1.43A 1fm6X-1gz4A:
0.0		 1fm6X-1gz4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 THR A 115
PRO A 109
THR A 113
 None
 0.83A 1i3wE-1gz4A:
undetectable		 1i3wE-1gz4A:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 THR A 115
PRO A 109
THR A 113
 None
 0.88A 1i3wG-1gz4A:
undetectable		 1i3wG-1gz4A:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 THR A 113
THR A 115
PRO A 109
 None
 0.79A 1qfiB-1gz4A:
undetectable		 1qfiB-1gz4A:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 THR A 115
PRO A 109
THR A 113
 None
 0.80A 209dC-1gz4A:
undetectable		 209dC-1gz4A:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 TRP A 558
GLU A  93
TYR A  97
 None
 1.24A 2a3aA-1gz4A:
undetectable		 2a3aA-1gz4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 PRO A 195
GLY A 182
PHE A  96
THR A 188
TYR A  97
 None
 1.33A 2axnA-1gz4A:
undetectable		 2axnA-1gz4A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 8 ILE A 135
ASP A 204
LEU A 234
GLU A 237
 None
 1.00A 2cdqA-1gz4A:
0.0		 2cdqA-1gz4A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 5 GLN A 253
PHE A 276
PHE A 491
GLY A 473
 None
 1.19A 2qmzA-1gz4A:
3.0
2qmzB-1gz4A:
2.9		 2qmzA-1gz4A:
17.19
2qmzB-1gz4A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 7 GLY A 192
GLY A 182
GLN A  89
PHE A  96
 None
 0.97A 2qwxA-1gz4A:
3.6
2qwxB-1gz4A:
3.7		 2qwxA-1gz4A:
18.44
2qwxB-1gz4A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 MET A 177
GLU A  90
ASN A  31
 None
 0.93A 3a27A-1gz4A:
3.9		 3a27A-1gz4A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 THR A 113
TYR A 513
LEU A 498
TYR A 187
ILE A 526
 None
 1.30A 3frqA-1gz4A:
0.0		 3frqA-1gz4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 LEU A 507
SER A 299
ILE A 298
ARG A 413
LEU A 442
 None
 1.32A 3ia4A-1gz4A:
undetectable		 3ia4A-1gz4A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 4 PRO A 195
TYR A  97
GLY A 192
THR A 557
 None
 1.15A 3ib0A-1gz4A:
0.7		 3ib0A-1gz4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 5 ILE A 389
PHE A 377
ASP A 379
GLU A 378
 None
 1.01A 3kp6A-1gz4A:
1.1
3kp6B-1gz4A:
1.3		 3kp6A-1gz4A:
15.19
3kp6B-1gz4A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 11 ILE A 470
ILE A 486
PHE A 491
ALA A 494
VAL A 478
 None
 0.97A 3kw4A-1gz4A:
0.0		 3kw4A-1gz4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 10 ALA A 289
GLY A 282
SER A 523
VAL A 522
LEU A 498
 None
 1.03A 3ogpA-1gz4A:
0.0		 3ogpA-1gz4A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 9 LYS A 496
LEU A 492
THR A 499
ALA A 495
LEU A 322
 None
 1.36A 3ozkA-1gz4A:
undetectable		 3ozkA-1gz4A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 GLY A 290
GLY A 463
ALA A 444
PHE A 443
ALA A 418
 None
 1.09A 3sudA-1gz4A:
undetectable		 3sudA-1gz4A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 10 GLY A 182
ALA A 189
VAL A 111
VAL A 468
CYH A 190
 None
 1.40A 4c5nD-1gz4A:
2.5		 4c5nD-1gz4A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 9 THR A 388
LEU A 292
LEU A 291
GLY A 290
VAL A 415
 None
 1.40A 4c9kB-1gz4A:
0.0		 4c9kB-1gz4A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 GLY A 465
GLY A 463
PHE A 443
ASN A 466
ILE A 319
 None
None
None
TTN  A 603 (-2.8A)
None
 1.03A 4n49A-1gz4A:
4.0		 4n49A-1gz4A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 LEU A 512
ALA A 293
LEU A 291
ALA A 444
ILE A 390
 None
 0.96A 4o2bD-1gz4A:
3.8		 4o2bD-1gz4A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 6 LYS A 496
LEU A 492
THR A 499
ALA A 495
LEU A 322
 None
 1.45A 4pwjA-1gz4A:
undetectable		 4pwjA-1gz4A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		6 / 11 LEU A 349
GLY A 311
ALA A 312
ILE A 358
ILE A 341
VAL A 351
 None
ATP  A 601 (-3.5A)
ATP  A 601 (-4.1A)
None
None
None
 1.44A 4q1xA-1gz4A:
undetectable		 4q1xA-1gz4A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		6 / 10 LEU A 349
GLY A 311
ALA A 312
ILE A 358
ILE A 341
VAL A 351
 None
ATP  A 601 (-3.5A)
ATP  A 601 (-4.1A)
None
None
None
 1.43A 4q1yA-1gz4A:
undetectable		 4q1yA-1gz4A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 8 TYR A 187
PHE A 471
PHE A 276
ILE A 166
 None
 0.95A 4qoiA-1gz4A:
3.6
4qoiB-1gz4A:
2.9		 4qoiA-1gz4A:
18.44
4qoiB-1gz4A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 LEU A 512
ALA A 293
LEU A 291
ALA A 444
ILE A 390
 None
 1.02A 4x20B-1gz4A:
3.6		 4x20B-1gz4A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 5 LEU A 322
ALA A 289
VAL A 474
ILE A 526
 None
 0.95A 4xe3A-1gz4A:
0.0		 4xe3A-1gz4A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 TYR A 273
THR A 250
THR A 275
 None
 0.82A 5aoxB-1gz4A:
0.0		 5aoxB-1gz4A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 TYR A 273
THR A 250
THR A 275
 None
 0.82A 5aoxE-1gz4A:
0.0		 5aoxE-1gz4A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 PRO A 386
ILE A 323
LEU A 308
VAL A 415
LEU A 288
 None
 1.03A 5bykA-1gz4A:
1.2		 5bykA-1gz4A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 ARG A 556
LYS A 551
GLU A 555
 ATP  A 602 (-4.0A)
None
None
 0.80A 5d0yA-1gz4A:
0.0		 5d0yA-1gz4A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 8 ILE A 404
PHE A 399
VAL A 403
GLU A 427
 None
 0.86A 5dqyA-1gz4A:
2.1		 5dqyA-1gz4A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 5 ILE A 390
GLY A 311
ILE A 319
LEU A 310
 None
ATP  A 601 (-3.5A)
None
ATP  A 601 (-4.9A)
 0.86A 5dzkB-1gz4A:
undetectable
5dzkI-1gz4A:
1.1
5dzkW-1gz4A:
undetectable		 5dzkB-1gz4A:
17.30
5dzkI-1gz4A:
16.64
5dzkW-1gz4A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 4 ILE A 390
GLY A 311
ILE A 319
LEU A 310
 None
ATP  A 601 (-3.5A)
None
ATP  A 601 (-4.9A)
 0.80A 5dzkl-1gz4A:
1.5
5dzkz-1gz4A:
undetectable		 5dzkl-1gz4A:
16.64
5dzkz-1gz4A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 6 VAL A 553
LYS A 549
ILE A 524
LYS A 529
 None
 1.36A 5q1sA-1gz4A:
2.0		 5q1sA-1gz4A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 7 GLY A 463
LEU A 292
GLY A 446
LEU A 419
ILE A 323
 None
 1.03A 5vkqA-1gz4A:
undetectable
5vkqB-1gz4A:
undetectable		 5vkqA-1gz4A:
14.80
5vkqB-1gz4A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 8 GLY A 463
LEU A 292
GLY A 446
LEU A 419
ILE A 323
 None
 1.03A 5vkqB-1gz4A:
undetectable
5vkqC-1gz4A:
undetectable		 5vkqB-1gz4A:
14.80
5vkqC-1gz4A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 10 ALA A 494
GLY A 282
THR A 283
ILE A 470
ALA A 289
 None
 1.16A 5vyhA-1gz4A:
0.0		 5vyhA-1gz4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 LEU A 512
ALA A 293
LEU A 291
ALA A 444
ILE A 390
 None
 1.00A 5xiwB-1gz4A:
2.2		 5xiwB-1gz4A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 12 PRO A 386
ILE A 323
LEU A 308
VAL A 415
LEU A 288
 None
 1.10A 6b52A-1gz4A:
1.1		 6b52A-1gz4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		3 / 3 ARG A  33
ARG A 194
ASP A 196
 None
 0.75A 6d8pA-1gz4A:
2.2		 6d8pA-1gz4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 5 PHE A 254
VAL A 478
MET A 239
VAL A 160
 None
 0.92A 6ekzA-1gz4A:
0.0		 6ekzA-1gz4A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 8 VAL A 160
ASN A 261
TYR A 231
GLU A 314
 None
None
None
ATP  A 601 (-4.1A)
 1.29A 6gneB-1gz4A:
2.8		 6gneB-1gz4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		5 / 7 TYR A 434
VAL A 392
ILE A 389
GLY A 510
ALA A 444
 None
ATP  A 601 (-3.6A)
None
None
None
 1.42A 6hd6B-1gz4A:
undetectable		 6hd6B-1gz4A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens) 		4 / 6 ARG A 165
GLU A 314
ASP A 279
GLU A 255
 ATP  A 601 ( 3.2A)
ATP  A 601 (-4.1A)
MN  A 604 ( 2.6A)
MN  A 604 ( 3.3A)
 1.48A 6mn5D-1gz4A:
1.7		 6mn5D-1gz4A:
9.33