SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gz5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A  11
GLU A  15
LEU A  28
ILE A 225
HIS A 154
 None
None
None
IMD  A 902 ( 4.3A)
IMD  A 902 (-3.9A)
 1.42A 1a52A-1gz5A:
undetectable		 1a52A-1gz5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A  11
GLU A  15
LEU A  28
ILE A 225
LEU A  23
 None
None
None
IMD  A 902 ( 4.3A)
G6P  A 901 ( 3.7A)
 1.47A 1a52A-1gz5A:
undetectable		 1a52A-1gz5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A  11
GLU A  15
LEU A  28
ILE A 225
HIS A 154
 None
None
None
IMD  A 902 ( 4.3A)
IMD  A 902 (-3.9A)
 1.44A 1a52B-1gz5A:
undetectable		 1a52B-1gz5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 8 GLN A 185
PRO A 224
GLU A 393
ASP A 361
 IMD  A 902 ( 4.7A)
None
None
UDP  A 900 ( 4.5A)
 1.17A 1dtlA-1gz5A:
undetectable		 1dtlA-1gz5A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 382
LEU A 355
ALA A 278
ALA A 275
VAL A 356
 None
 1.34A 1kt4A-1gz5A:
0.0		 1kt4A-1gz5A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 268
GLU A 271
LEU A 263
ILE A 309
HIS A  89
 None
 1.19A 1kyvA-1gz5A:
undetectable
1kyvE-1gz5A:
4.8		 1kyvA-1gz5A:
15.20
1kyvE-1gz5A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 HIS A  89
GLY A 268
GLU A 271
LEU A 263
ILE A 309
 None
 1.19A 1kyvB-1gz5A:
2.8
1kyvC-1gz5A:
3.1		 1kyvB-1gz5A:
15.20
1kyvC-1gz5A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 HIS A  89
GLY A 268
GLU A 271
LEU A 263
ILE A 309
 None
 1.23A 1kyvC-1gz5A:
3.0
1kyvD-1gz5A:
5.0		 1kyvC-1gz5A:
15.20
1kyvD-1gz5A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 HIS A  89
GLY A 268
GLU A 271
LEU A 263
ILE A 309
 None
 1.23A 1kyvD-1gz5A:
5.0
1kyvE-1gz5A:
4.7		 1kyvD-1gz5A:
15.20
1kyvE-1gz5A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.84A 1muiB-1gz5A:
undetectable		 1muiB-1gz5A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.79A 1n49B-1gz5A:
undetectable		 1n49B-1gz5A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.80A 1n49C-1gz5A:
undetectable		 1n49C-1gz5A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A  11
GLU A  15
LEU A  28
ILE A 225
HIS A 154
 None
None
None
IMD  A 902 ( 4.3A)
IMD  A 902 (-3.9A)
 1.31A 1qkuA-1gz5A:
0.0		 1qkuA-1gz5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A  11
GLU A  15
LEU A  28
ILE A 225
HIS A 154
 None
None
None
IMD  A 902 ( 4.3A)
IMD  A 902 (-3.9A)
 1.32A 1qkuB-1gz5A:
undetectable		 1qkuB-1gz5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A  11
GLU A  15
LEU A  28
ILE A 225
HIS A 154
 None
None
None
IMD  A 902 ( 4.3A)
IMD  A 902 (-3.9A)
 1.31A 1qkuC-1gz5A:
undetectable		 1qkuC-1gz5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.80A 1sguB-1gz5A:
undetectable		 1sguB-1gz5A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.78A 1t3rA-1gz5A:
undetectable		 1t3rA-1gz5A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.82A 1t7iA-1gz5A:
undetectable		 1t7iA-1gz5A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.91A 2aquB-1gz5A:
undetectable		 2aquB-1gz5A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.75A 2avvB-1gz5A:
undetectable		 2avvB-1gz5A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.86A 2b60A-1gz5A:
undetectable		 2b60A-1gz5A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.72A 2b7zB-1gz5A:
undetectable		 2b7zB-1gz5A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 8 LEU A  31
HIS A 129
HIS A 154
ALA A  30
 None
None
IMD  A 902 (-3.9A)
None
 0.86A 2bnnA-1gz5A:
undetectable
2bnnB-1gz5A:
undetectable		 2bnnA-1gz5A:
17.98
2bnnB-1gz5A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 8 GLN A  96
PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.32A 2eilP-1gz5A:
undetectable
2eilW-1gz5A:
0.0		 2eilP-1gz5A:
19.91
2eilW-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 ALA A 275
GLY A 268
SER A 259
 None
 0.59A 2ivuA-1gz5A:
0.0		 2ivuA-1gz5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.89A 2nmzB-1gz5A:
undetectable		 2nmzB-1gz5A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 LEU A 313
LEU A 359
PHE A 273
 None
 0.69A 2pgrA-1gz5A:
undetectable		 2pgrA-1gz5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.88A 2r5qB-1gz5A:
undetectable		 2r5qB-1gz5A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.88A 2r5qD-1gz5A:
undetectable		 2r5qD-1gz5A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.23A 2y69C-1gz5A:
0.0
2y69J-1gz5A:
0.0		 2y69C-1gz5A:
19.91
2y69J-1gz5A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.24A 2y69P-1gz5A:
undetectable
2y69W-1gz5A:
0.0		 2y69P-1gz5A:
19.91
2y69W-1gz5A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 4 ARG A 405
ASP A 406
LEU A 412
ARG A 319
 None
 1.45A 2ziaB-1gz5A:
2.3		 2ziaB-1gz5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 GLN A  96
PHE A  97
LEU A  84
PHE A  88
 None
 1.36A 3ablC-1gz5A:
undetectable
3ablJ-1gz5A:
0.0		 3ablC-1gz5A:
19.91
3ablJ-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.24A 3abmC-1gz5A:
undetectable
3abmJ-1gz5A:
0.0		 3abmC-1gz5A:
19.91
3abmJ-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.21A 3abmP-1gz5A:
undetectable
3abmW-1gz5A:
0.0		 3abmP-1gz5A:
19.91
3abmW-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.14A 3ag3C-1gz5A:
undetectable
3ag3J-1gz5A:
0.0		 3ag3C-1gz5A:
19.91
3ag3J-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 8 PHE A 157
PHE A  88
LEU A  84
PHE A  79
 None
 0.97A 3asoC-1gz5A:
undetectable
3asoJ-1gz5A:
0.0		 3asoC-1gz5A:
19.91
3asoJ-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 8 LEU A 382
THR A 357
ALA A 390
ALA A 388
 None
 0.92A 3ax9B-1gz5A:
0.0		 3ax9B-1gz5A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 6 ASP A 178
LEU A 140
ASP A 180
LEU A 450
 None
 1.06A 3bj8C-1gz5A:
0.0
3bj8D-1gz5A:
0.0		 3bj8C-1gz5A:
17.98
3bj8D-1gz5A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 274
LEU A 313
SER A 259
LEU A 332
ALA A 275
 None
 1.03A 3dfrA-1gz5A:
undetectable		 3dfrA-1gz5A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.84A 3jw2B-1gz5A:
undetectable		 3jw2B-1gz5A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.79A 3lzvA-1gz5A:
undetectable		 3lzvA-1gz5A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A 382
ALA A 390
GLY A 226
ILE A 227
LEU A 394
 None
 1.05A 3ogpA-1gz5A:
undetectable		 3ogpA-1gz5A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 GLU A 250
LEU A 247
GLN A 246
LYS A 243
 None
 0.86A 3pgyB-1gz5A:
1.5		 3pgyB-1gz5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 4 PHE A  97
TYR A 169
ARG A 360
LEU A  94
 None
 0.81A 3sueA-1gz5A:
0.0		 3sueA-1gz5A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 11 HIS A 129
ILE A 225
LEU A 394
ASP A 361
GLY A 362
 None
IMD  A 902 ( 4.3A)
None
UDP  A 900 ( 4.5A)
None
 1.04A 4fogC-1gz5A:
0.0		 4fogC-1gz5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 359
GLU A 271
LEU A 269
LEU A 263
LEU A  94
 None
 1.21A 4j24D-1gz5A:
undetectable		 4j24D-1gz5A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  80
TYR A 105
PRO A  86
 None
 0.75A 4k8cA-1gz5A:
5.4		 4k8cA-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A 266
TYR A 265
PRO A 156
 None
 0.93A 4k8cA-1gz5A:
5.4		 4k8cA-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  80
TYR A 105
PRO A  86
 None
 0.73A 4kahA-1gz5A:
5.3		 4kahA-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A 266
TYR A 265
PRO A 156
 None
 0.95A 4kahA-1gz5A:
5.3		 4kahA-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  80
TYR A 105
PRO A  86
 None
 0.72A 4kahB-1gz5A:
4.6		 4kahB-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A 266
TYR A 265
PRO A 156
 None
 0.94A 4kahB-1gz5A:
4.6		 4kahB-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  80
TYR A 105
PRO A  86
 None
 0.76A 4kanA-1gz5A:
5.3		 4kanA-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A 266
TYR A 265
PRO A 156
 None
 0.94A 4kanA-1gz5A:
5.3		 4kanA-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  80
TYR A 105
PRO A  86
 None
 0.74A 4kanB-1gz5A:
4.8		 4kanB-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A 266
TYR A 265
PRO A 156
 None
 0.93A 4kanB-1gz5A:
4.8		 4kanB-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  80
TYR A 105
PRO A  86
 None
 0.72A 4kbeA-1gz5A:
5.2		 4kbeA-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A 266
TYR A 265
PRO A 156
 None
 0.94A 4kbeA-1gz5A:
5.2		 4kbeA-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  80
TYR A 105
PRO A  86
 None
 0.73A 4kbeB-1gz5A:
5.3		 4kbeB-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A 266
TYR A 265
PRO A 156
 None
 0.91A 4kbeB-1gz5A:
5.3		 4kbeB-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  80
TYR A 105
PRO A  86
 None
 0.74A 4lbgA-1gz5A:
4.9		 4lbgA-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A 266
TYR A 265
PRO A 156
 None
 0.96A 4lbgA-1gz5A:
4.9		 4lbgA-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A  80
TYR A 105
PRO A  86
 None
 0.74A 4lbgB-1gz5A:
4.8		 4lbgB-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A 266
TYR A 265
PRO A 156
 None
 0.96A 4lbgB-1gz5A:
4.8		 4lbgB-1gz5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ALA A 367
GLY A 354
LEU A 382
LEU A 394
 None
 0.72A 4po0A-1gz5A:
0.0		 4po0A-1gz5A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.79A 4q1xA-1gz5A:
undetectable		 4q1xA-1gz5A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 ILE A 155
SER A  80
HIS A 132
ASP A 264
 G6P  A 901 (-4.8A)
None
G6P  A 901 (-4.5A)
None
 1.37A 4rzvB-1gz5A:
0.0		 4rzvB-1gz5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 7 PRO A 158
PHE A  88
TRP A  85
TYR A 265
 None
 1.44A 4v2yA-1gz5A:
undetectable		 4v2yA-1gz5A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 7 PRO A 158
PHE A  88
TRP A  85
TYR A 265
 None
 1.48A 4v30A-1gz5A:
undetectable		 4v30A-1gz5A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 VAL A 408
LEU A 412
VAL A 383
 None
 0.62A 4wq4A-1gz5A:
undetectable		 4wq4A-1gz5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 TYR A 324
ARG A 319
LYS A 323
 None
 1.27A 4wq5B-1gz5A:
1.3		 4wq5B-1gz5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 6 ALA A 372
LEU A 431
MET A 430
LEU A 394
 None
 1.15A 4xoyA-1gz5A:
undetectable		 4xoyA-1gz5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 PHE A  79
ILE A 155
LEU A 166
LEU A 172
LEU A 134
 None
G6P  A 901 (-4.8A)
None
None
None
 1.22A 4xumA-1gz5A:
undetectable		 4xumA-1gz5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 7 PRO A 158
PHE A  88
TRP A  85
TYR A 265
 None
 1.47A 5amkB-1gz5A:
0.0		 5amkB-1gz5A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 7 GLN A  96
PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.42A 5b1aC-1gz5A:
undetectable
5b1aJ-1gz5A:
0.0		 5b1aC-1gz5A:
19.91
5b1aJ-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 7 PHE A 157
PHE A  88
LEU A  84
PHE A  79
 None
 0.97A 5b1aC-1gz5A:
undetectable
5b1aJ-1gz5A:
0.0		 5b1aC-1gz5A:
19.91
5b1aJ-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 7 GLN A  96
PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.38A 5b1aP-1gz5A:
undetectable
5b1aW-1gz5A:
0.0		 5b1aP-1gz5A:
19.91
5b1aW-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 6 PHE A 157
PHE A  88
LEU A  84
PHE A  79
 None
 1.04A 5b1bC-1gz5A:
undetectable
5b1bJ-1gz5A:
0.0		 5b1bC-1gz5A:
19.91
5b1bJ-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  22
ILE A  27
HIS A 129
GLY A  29
PHE A 152
 IMD  A 902 (-3.0A)
None
None
None
None
 1.09A 5d4uA-1gz5A:
undetectable		 5d4uA-1gz5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A 394
ILE A 434
ALA A 372
VAL A 366
PRO A 358
 None
None
None
UDP  A 900 (-3.9A)
None
 1.31A 5m0oA-1gz5A:
0.0		 5m0oA-1gz5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 6 ALA A 415
LEU A 412
ILE A 257
TYR A 370
 None
 0.88A 5mvmB-1gz5A:
0.0
5mvmC-1gz5A:
0.0		 5mvmB-1gz5A:
11.97
5mvmC-1gz5A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASN A 188
ARG A 190
THR A 220
GLY A 183
 None
 0.82A 5nzxA-1gz5A:
0.9		 5nzxA-1gz5A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 7 PRO A 158
PHE A  88
TRP A  85
TYR A 265
 None
 1.43A 5oh1A-1gz5A:
undetectable		 5oh1A-1gz5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 7 PRO A 158
PHE A  88
TRP A  85
TYR A 265
 None
 1.48A 5oh1B-1gz5A:
undetectable		 5oh1B-1gz5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 6 TYR A  76
TYR A  75
ASP A 302
TYR A 131
 G6P  A 901 (-4.5A)
None
None
G6P  A 901 ( 4.8A)
 1.47A 5ov9A-1gz5A:
0.0		 5ov9A-1gz5A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.16A 5wauC-1gz5A:
0.0
5wauJ-1gz5A:
0.0		 5wauC-1gz5A:
19.91
5wauJ-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.15A 5wauc-1gz5A:
undetectable
5wauj-1gz5A:
0.0		 5wauc-1gz5A:
19.91
5wauj-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.16A 5xdqC-1gz5A:
0.0
5xdqJ-1gz5A:
0.0		 5xdqC-1gz5A:
19.91
5xdqJ-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 5 PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.15A 5xdqP-1gz5A:
undetectable
5xdqW-1gz5A:
0.0		 5xdqP-1gz5A:
19.91
5xdqW-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 8 PHE A  88
LEU A 166
ALA A 165
LEU A  92
 None
 0.85A 5y7pC-1gz5A:
undetectable		 5y7pC-1gz5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 6 PHE A 157
PHE A  88
LEU A  84
PHE A  79
 None
 1.01A 5z84P-1gz5A:
undetectable
5z84W-1gz5A:
0.0		 5z84P-1gz5A:
19.91
5z84W-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 6 PHE A 157
PHE A  88
LEU A  84
PHE A  79
 None
 0.99A 5z85P-1gz5A:
undetectable
5z85W-1gz5A:
0.0		 5z85P-1gz5A:
19.91
5z85W-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		4 / 6 PHE A 157
PHE A  88
LEU A  84
PHE A  79
 None
 1.01A 5z86P-1gz5A:
undetectable
5z86W-1gz5A:
0.0		 5z86P-1gz5A:
19.91
5z86W-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 9 VAL A   6
GLY A  40
LEU A 117
LYS A 115
ASP A 124
 None
 1.20A 6c2mC-1gz5A:
undetectable		 6c2mC-1gz5A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A  11
GLU A  15
LEU A  28
ILE A 225
HIS A 154
 None
None
None
IMD  A 902 ( 4.3A)
IMD  A 902 (-3.9A)
 1.37A 6cbzB-1gz5A:
undetectable		 6cbzB-1gz5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		3 / 3 LEU A 181
ASP A 130
ILE A  27
 None
G6P  A 901 (-3.3A)
None
 0.60A 6dh0B-1gz5A:
0.0		 6dh0B-1gz5A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 389
ALA A 390
ILE A 434
GLY A 226
ILE A 225
 None
None
None
None
IMD  A 902 ( 4.3A)
 0.87A 6dilB-1gz5A:
undetectable		 6dilB-1gz5A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE
(Escherichia
coli) 		6 / 12 GLY A  21
GLY A  22
LEU A  23
GLY A 301
HIS A 132
ARG A 262
 UDP  A 900 (-3.4A)
IMD  A 902 (-3.0A)
G6P  A 901 ( 3.7A)
None
G6P  A 901 (-4.5A)
UDP  A 900 ( 3.8A)
 1.16A 6gngB-1gz5A:
22.1		 6gngB-1gz5A:
22.64