SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		5 / 12 THR A 131
SER A 127
GLY A  79
THR A  15
VAL A  96
 None
 1.13A 1jg4A-1gz6A:
5.1		 1jg4A-1gz6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		4 / 8 LEU A  21
VAL A 239
GLY A 240
TYR A  25
 NAI  A1306 (-4.0A)
None
None
None
 1.04A 1jlfA-1gz6A:
0.0
1jlfB-1gz6A:
undetectable		 1jlfA-1gz6A:
21.99
1jlfB-1gz6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		4 / 5 LEU A 172
ALA A 150
LEU A 169
SER A 165
 None
 1.02A 1tt6B-1gz6A:
undetectable		 1tt6B-1gz6A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		4 / 6 LEU A 172
ALA A 150
LEU A 169
SER A 165
 None
 0.95A 1tz8C-1gz6A:
undetectable
1tz8D-1gz6A:
undetectable		 1tz8C-1gz6A:
17.93
1tz8D-1gz6A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		5 / 10 ARG A  65
GLU A 216
GLY A  22
GLY A  20
ALA A  28
 None
None
None
NAI  A1306 (-3.4A)
None
 0.97A 1x7pA-1gz6A:
2.9
1x7pB-1gz6A:
2.2		 1x7pA-1gz6A:
22.88
1x7pB-1gz6A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		5 / 12 GLY A 101
SER A  75
GLY A 170
LEU A 171
LEU A 174
 NAI  A1306 (-3.6A)
NAI  A1306 (-3.2A)
None
None
None
 0.92A 2hw2A-1gz6A:
0.0		 2hw2A-1gz6A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		4 / 9 ILE A 147
ALA A 219
VAL A 222
CYH A 226
 None
 0.89A 2vufB-1gz6A:
undetectable		 2vufB-1gz6A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		5 / 10 ILE A 155
SER A 165
LYS A 168
GLY A 154
LEU A 236
 None
None
NAI  A1306 (-2.9A)
None
None
 1.43A 3ik6B-1gz6A:
0.0
3ik6E-1gz6A:
0.0		 3ik6B-1gz6A:
21.97
3ik6E-1gz6A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		5 / 11 TYR A 164
ILE A 119
GLY A 101
ALA A 100
VAL A 130
 NAI  A1306 (-4.4A)
None
NAI  A1306 (-3.6A)
NAI  A1306 (-3.4A)
None
 1.10A 3rukD-1gz6A:
undetectable		 3rukD-1gz6A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		5 / 12 VAL A  11
GLY A  18
ALA A  17
THR A  15
ALA A 100
 None
NAI  A1306 ( 4.2A)
None
None
NAI  A1306 (-3.4A)
 1.08A 3sugA-1gz6A:
undetectable		 3sugA-1gz6A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		5 / 12 VAL A  58
ILE A  62
GLU A 216
TYR A  25
VAL A  36
 None
 1.12A 4a97B-1gz6A:
0.0
4a97C-1gz6A:
0.0		 4a97B-1gz6A:
21.75
4a97C-1gz6A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		5 / 11 ILE A 187
ILE A 146
LEU A 174
ALA A 133
ILE A  93
 None
 1.10A 4h1nA-1gz6A:
undetectable		 4h1nA-1gz6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		4 / 6 LEU A 172
ALA A 150
LEU A 169
SER A 165
 None
 0.99A 4pwjA-1gz6A:
0.0		 4pwjA-1gz6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		5 / 12 GLY A 173
GLU A 238
ALA A 152
GLY A 154
TYR A 156
 None
 1.10A 4r29B-1gz6A:
0.0		 4r29B-1gz6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		4 / 7 ILE A 180
GLY A 234
LEU A 172
MET A 148
 None
 0.88A 4zdzA-1gz6A:
0.0		 4zdzA-1gz6A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		5 / 12 GLY A  16
ASP A  40
LEU A  41
SER A  75
VAL A 122
 NAI  A1306 (-3.6A)
NAI  A1306 (-2.8A)
NAI  A1306 (-4.2A)
NAI  A1306 (-3.2A)
NAI  A1306 ( 4.1A)
 0.73A 5dpdB-1gz6A:
7.0		 5dpdB-1gz6A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		5 / 12 VAL A  76
LEU A 103
SER A 127
GLY A  22
LEU A  21
 NAI  A1306 (-3.6A)
None
None
None
NAI  A1306 (-4.0A)
 1.23A 5m50E-1gz6A:
6.0		 5m50E-1gz6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		5 / 12 GLY A  16
GLY A  18
ASP A  40
SER A  75
VAL A  76
 NAI  A1306 (-3.6A)
NAI  A1306 ( 4.2A)
NAI  A1306 (-2.8A)
NAI  A1306 (-3.2A)
NAI  A1306 (-3.6A)
 0.49A 5wy0A-1gz6A:
2.6		 5wy0A-1gz6A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		4 / 4 HIS A 123
LEU A  21
TYR A  25
GLY A  16
 NAI  A1306 (-4.6A)
NAI  A1306 (-4.0A)
None
NAI  A1306 (-3.6A)
 1.44A 6n91A-1gz6A:
1.2		 6n91A-1gz6A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4
(Rattus
norvegicus) 		4 / 4 HIS A 123
LEU A  21
TYR A  25
GLY A  16
 NAI  A1306 (-4.6A)
NAI  A1306 (-4.0A)
None
NAI  A1306 (-3.6A)
 1.44A 6n91B-1gz6A:
0.4		 6n91B-1gz6A:
14.24