SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gzc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		5 / 11 SER A 152
LEU A 109
GLY A 144
HIS A 226
GLU A 224
 MN  A 289 ( 4.1A)
None
None
None
None
 1.44A 1iolA-1gzcA:
undetectable		 1iolA-1gzcA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		5 / 11 PHE A 158
TYR A 192
ALA A 190
SER A 188
ASP A 227
 None
 1.19A 2iyfA-1gzcA:
undetectable		 2iyfA-1gzcA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		5 / 12 GLY A  90
ALA A  88
PHE A 131
THR A 130
LEU A 160
 None
LAT  A1559 ( 3.8A)
LAT  A1559 ( 3.7A)
None
None
 0.72A 3dh0A-1gzcA:
undetectable		 3dh0A-1gzcA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		4 / 6 HIS A 142
VAL A 181
ILE A 150
LEU A 179
 MN  A 289 (-3.5A)
None
None
None
 0.81A 3kk6A-1gzcA:
undetectable		 3kk6A-1gzcA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		4 / 4 GLY A 105
TYR A 106
GLY A 217
ASP A  46
 None
None
LAT  A1559 (-3.1A)
None
 1.04A 3kl3A-1gzcA:
undetectable		 3kl3A-1gzcA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		4 / 4 LEU A  91
GLY A  90
GLY A 214
THR A  35
 None
 0.91A 3si7A-1gzcA:
undetectable		 3si7A-1gzcA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		4 / 5 GLU A  10
GLY A  30
TYR A 229
ASP A 227
 None
 1.25A 3w9tD-1gzcA:
0.0		 3w9tD-1gzcA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		4 / 5 ALA A 190
TYR A 185
PRO A 141
PHE A  76
 None
 1.22A 4ze2A-1gzcA:
0.0		 4ze2A-1gzcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		4 / 7 ILE A 197
VAL A 198
TYR A 172
GLN A 202
 None
 1.01A 5kkzC-1gzcA:
0.5
5kkzE-1gzcA:
undetectable		 5kkzC-1gzcA:
21.86
5kkzE-1gzcA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		4 / 7 ILE A 197
VAL A 198
TYR A 172
GLN A 202
 None
 1.00A 5kkzK-1gzcA:
undetectable
5kkzQ-1gzcA:
0.7		 5kkzK-1gzcA:
20.18
5kkzQ-1gzcA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		4 / 7 ILE A 197
VAL A 198
TYR A 172
GLN A 202
 None
 0.95A 5kkzM-1gzcA:
0.5
5kkzO-1gzcA:
undetectable		 5kkzM-1gzcA:
21.86
5kkzO-1gzcA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		5 / 12 ILE A  78
LEU A 160
PRO A  87
GLY A  90
ASP A 129
 None
None
None
None
CA  A 290 ( 2.1A)
 1.15A 5nnaC-1gzcA:
undetectable		 5nnaC-1gzcA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		5 / 12 ILE A  78
LEU A 160
PRO A  87
GLY A  90
ASP A 129
 None
None
None
None
CA  A 290 ( 2.1A)
 1.17A 5nnaD-1gzcA:
undetectable		 5nnaD-1gzcA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		4 / 6 ILE A 170
MET A  95
THR A 123
LEU A 124
 None
 1.04A 5z86N-1gzcA:
undetectable
5z86W-1gzcA:
undetectable		 5z86N-1gzcA:
19.13
5z86W-1gzcA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 1gzc ERYTHRINA
CRISTA-GALLI LECTIN
(Erythrina
crista-galli) 		5 / 10 TYR A 172
PHE A  93
ALA A 125
THR A 123
LEU A 204
 None
 1.48A 6ay4A-1gzcA:
undetectable		 6ay4A-1gzcA:
19.87