SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 0.99A 2q5kA-1gzgA:
undetectable		 2q5kA-1gzgA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 106
SER A 163
ILE A 107
GLU A 100
 None
 0.82A 3a7eA-1gzgA:
undetectable		 3a7eA-1gzgA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 1.00A 3ekvB-1gzgA:
undetectable		 3ekvB-1gzgA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A 249
ASP A 179
ILE A 154
VAL A 199
ILE A 182
 MG  A1338 ( 3.8A)
None
None
None
None
 1.05A 3ekyB-1gzgA:
undetectable		 3ekyB-1gzgA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  37
ILE A 321
VAL A 282
VAL A 269
 None
 0.75A 3fi0G-1gzgA:
undetectable		 3fi0G-1gzgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  37
ILE A 321
VAL A 282
VAL A 269
 None
 0.76A 3fi0I-1gzgA:
undetectable		 3fi0I-1gzgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 0.99A 3lzvB-1gzgA:
undetectable		 3lzvB-1gzgA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A 249
ASP A 179
ILE A 154
VAL A 199
ILE A 182
 MG  A1338 ( 3.8A)
None
None
None
None
 1.04A 3ndwB-1gzgA:
undetectable		 3ndwB-1gzgA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 0.98A 3nu6A-1gzgA:
0.0		 3nu6A-1gzgA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 0.97A 3nujA-1gzgA:
undetectable		 3nujA-1gzgA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 11 ASP A 249
ASP A 179
ILE A 154
VAL A 199
ILE A 182
 MG  A1338 ( 3.8A)
None
None
None
None
 1.08A 3oxxB-1gzgA:
undetectable		 3oxxB-1gzgA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 266
PHE A 281
THR A 323
ILE A  80
LEU A  33
 None
 1.19A 3sp9A-1gzgA:
0.0		 3sp9A-1gzgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 266
PHE A 281
THR A 323
ILE A  80
LEU A  33
 None
 1.16A 3sp9B-1gzgA:
undetectable		 3sp9B-1gzgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 309
ARG A 315
GLY A 262
GLN A 284
 None
 1.02A 4af0A-1gzgA:
11.0		 4af0A-1gzgA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 289
TYR A 324
VAL A 218
ILE A  54
 None
LAF  A1337 (-4.6A)
None
None
 1.10A 4aftD-1gzgA:
0.0
4aftE-1gzgA:
0.0		 4aftD-1gzgA:
21.52
4aftE-1gzgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 1.02A 4dqcA-1gzgA:
undetectable		 4dqcA-1gzgA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A  66
SER A  64
ARG A  51
GLU A  71
 None
 1.26A 4eysA-1gzgA:
undetectable		 4eysA-1gzgA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 7 PRO A 174
ARG A 181
GLY A 183
ALA A 161
 None
MG  A1338 (-4.7A)
None
None
 0.96A 4g0uB-1gzgA:
undetectable		 4g0uB-1gzgA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 0.97A 4jecB-1gzgA:
undetectable		 4jecB-1gzgA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 7 GLN A 160
THR A 126
THR A 112
THR A 195
 None
 1.08A 4mbsA-1gzgA:
0.0		 4mbsA-1gzgA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 1.02A 4q1wB-1gzgA:
undetectable		 4q1wB-1gzgA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 0.98A 4rvjA-1gzgA:
undetectable		 4rvjA-1gzgA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 0.98A 4rvjC-1gzgA:
undetectable		 4rvjC-1gzgA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 181
ASP A 176
TYR A 202
 MG  A1338 (-4.7A)
None
LAF  A1337 ( 4.6A)
 0.87A 4yo9B-1gzgA:
0.0		 4yo9B-1gzgA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 7 LEU A  83
LEU A  85
ALA A 111
LEU A 122
ALA A  72
 None
None
None
SO4  A1340 (-4.8A)
None
 1.24A 4z90F-1gzgA:
0.0
4z90G-1gzgA:
0.0
4z90H-1gzgA:
0.0
4z90J-1gzgA:
0.0		 4z90F-1gzgA:
21.59
4z90G-1gzgA:
21.59
4z90H-1gzgA:
21.59
4z90J-1gzgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 153
GLY A 137
HIS A 136
THR A 134
 None
 0.91A 5eevL-1gzgA:
undetectable
5eevV-1gzgA:
undetectable		 5eevL-1gzgA:
14.07
5eevV-1gzgA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 153
GLY A 137
HIS A 136
THR A 134
 None
 0.91A 5eewL-1gzgA:
undetectable
5eewV-1gzgA:
0.0		 5eewL-1gzgA:
14.07
5eewV-1gzgA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 153
GLY A 137
HIS A 136
THR A 134
 None
 0.91A 5ef3L-1gzgA:
undetectable
5ef3V-1gzgA:
0.0		 5ef3L-1gzgA:
14.07
5ef3V-1gzgA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 211
TYR A 324
GLY A 262
ASP A 267
 LAF  A1336 ( 3.9A)
LAF  A1337 (-4.6A)
None
None
 1.34A 5emlA-1gzgA:
6.0		 5emlA-1gzgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 317
LEU A 322
PHE A  86
TYR A 324
THR A 280
MET A 258
 None
None
LAF  A1337 (-4.4A)
LAF  A1337 (-4.6A)
None
None
 1.48A 5eskA-1gzgA:
0.0		 5eskA-1gzgA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		3 / 3 ILE A 185
MET A 258
ASP A 176
 None
 0.72A 5h2uA-1gzgA:
undetectable		 5h2uA-1gzgA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  80
PRO A  81
ALA A 312
GLY A 262
TYR A 283
 None
None
None
None
LAF  A1337 (-3.5A)
 1.04A 5igtA-1gzgA:
0.0		 5igtA-1gzgA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 1.01A 6dgxB-1gzgA:
undetectable		 6dgxB-1gzgA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 1.02A 6dh3B-1gzgA:
undetectable		 6dh3B-1gzgA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  82
VAL A 171
GLY A 320
ILE A 321
ILE A 125
 None
 0.98A 6dj2A-1gzgA:
undetectable		 6dj2A-1gzgA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 240
ASP A 274
ASN A  31
 None
 0.82A 6gngB-1gzgA:
3.5		 6gngB-1gzgA:
20.48