SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 6 ILE B1952
ARG B1811
PHE B1816
PHE B1869
 None
 1.28A 1e73M-1gzhB:
undetectable		 1e73M-1gzhB:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 9 ILE B1952
ILE B1957
GLY B1954
GLU B1955
GLN B1949
 None
 1.09A 2dtjA-1gzhB:
undetectable
2dtjB-1gzhB:
undetectable		 2dtjA-1gzhB:
20.23
2dtjB-1gzhB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 7 ILE B1859
GLY B1851
ARG B1811
LEU B1854
 None
 0.97A 2vctD-1gzhB:
2.2		 2vctD-1gzhB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 12 GLN B1949
LEU B1872
VAL B1919
VAL B1874
LEU B1892
 None
 1.05A 3gwxB-1gzhB:
0.0		 3gwxB-1gzhB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 6 SER B1834
ARG B1781
GLY B1785
GLU B1789
 None
 1.05A 3k9fA-1gzhB:
undetectable
3k9fB-1gzhB:
undetectable
3k9fD-1gzhB:
undetectable		 3k9fA-1gzhB:
19.60
3k9fB-1gzhB:
19.60
3k9fD-1gzhB:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 12 LEU B1840
TYR B1732
PHE B1734
LEU B1803
LEU B1736
 None
 1.24A 3vw1B-1gzhB:
undetectable		 3vw1B-1gzhB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 8 SER B1889
TRP B1888
PHE B1869
GLU B1890
 None
 1.17A 4cx7A-1gzhB:
0.0
4cx7B-1gzhB:
0.0		 4cx7A-1gzhB:
22.43
4cx7B-1gzhB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens) 		4 / 6 LEU B1819
TRP B1888
PHE B1791
THR B1894
 None
 1.12A 4udaA-1gzhB:
undetectable		 4udaA-1gzhB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens) 		3 / 3 TRP B1946
ARG B1956
LEU B1951
 None
 0.72A 5dbyA-1gzhB:
undetectable		 5dbyA-1gzhB:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens) 		5 / 11 VAL B1921
VAL B1874
VAL B1919
PHE B1869
LEU B1892
 None
 1.13A 5e4dB-1gzhB:
0.0		 5e4dB-1gzhB:
21.72