SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gzj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1gzj EGI
(Thermoascus
aurantiacus) 		4 / 8 ALA A 173
GLY A 236
ILE A 237
ILE A 222
 None
 0.71A 1d4yB-1gzjA:
undetectable		 1d4yB-1gzjA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1gzj EGI
(Thermoascus
aurantiacus) 		4 / 7 ILE A 150
THR A 130
GLN A 147
MET A 183
 None
 1.19A 1kglA-1gzjA:
0.0		 1kglA-1gzjA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1gzj EGI
(Thermoascus
aurantiacus) 		4 / 7 TRP A 113
GLY A 157
GLN A 119
PHE A 128
 None
 0.85A 2qwxA-1gzjA:
2.1
2qwxB-1gzjA:
2.1		 2qwxA-1gzjA:
20.89
2qwxB-1gzjA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 1gzj EGI
(Thermoascus
aurantiacus) 		6 / 12 ASN A 132
GLU A 133
HIS A 198
TYR A 200
GLU A 240
TRP A 273
 None
 0.79A 2v3dA-1gzjA:
17.0		 2v3dA-1gzjA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1gzj EGI
(Thermoascus
aurantiacus) 		5 / 11 ASN A 132
GLU A 133
TYR A 200
GLU A 240
TRP A 273
 None
 0.89A 2v3dB-1gzjA:
6.3		 2v3dB-1gzjA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1gzj EGI
(Thermoascus
aurantiacus) 		4 / 8 LEU A 301
PRO A 303
ALA A 261
PHE A   4
 None
 0.80A 2vcvF-1gzjA:
undetectable		 2vcvF-1gzjA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1gzj EGI
(Thermoascus
aurantiacus) 		4 / 8 LEU A 301
PRO A 303
ALA A 261
PHE A   4
 None
 0.84A 2vcvP-1gzjA:
0.0		 2vcvP-1gzjA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 1gzj EGI
(Thermoascus
aurantiacus) 		5 / 12 ARG A  49
GLU A 166
TYR A 200
ASN A 132
HIS A  93
 None
 1.50A 3bjmA-1gzjA:
undetectable		 3bjmA-1gzjA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 1gzj EGI
(Thermoascus
aurantiacus) 		5 / 12 ARG A  49
GLU A 166
TYR A 200
ASN A 132
HIS A  93
 None
 1.49A 3bjmB-1gzjA:
undetectable		 3bjmB-1gzjA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 1gzj EGI
(Thermoascus
aurantiacus) 		5 / 12 GLY A 236
VAL A 266
MET A 260
LEU A 257
ILE A 222
 None
 1.18A 3h52A-1gzjA:
undetectable		 3h52A-1gzjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1gzj EGI
(Thermoascus
aurantiacus) 		3 / 3 SER A 155
GLY A 152
SER A 118
 None
 0.44A 3loqA-1gzjA:
2.9		 3loqA-1gzjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1gzj EGI
(Thermoascus
aurantiacus) 		5 / 11 GLY A 152
ALA A 148
ILE A 153
PHE A 112
ALA A 117
 None
 1.06A 3nmuB-1gzjA:
0.2
3nmuJ-1gzjA:
undetectable		 3nmuB-1gzjA:
22.83
3nmuJ-1gzjA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1gzj EGI
(Thermoascus
aurantiacus) 		5 / 12 ARG A  49
GLU A 166
TYR A 200
ASN A 132
HIS A  93
 None
 1.49A 3w2tA-1gzjA:
undetectable		 3w2tA-1gzjA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1gzj EGI
(Thermoascus
aurantiacus) 		5 / 12 ARG A  49
GLU A 166
TYR A 200
ASN A 132
HIS A  93
 None
 1.46A 3w2tB-1gzjA:
undetectable		 3w2tB-1gzjA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1gzj EGI
(Thermoascus
aurantiacus) 		3 / 3 ASN A  10
TRP A 273
ASP A 129
 None
 1.22A 4a7tA-1gzjA:
undetectable
4a7tF-1gzjA:
0.0		 4a7tA-1gzjA:
20.88
4a7tF-1gzjA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 1gzj EGI
(Thermoascus
aurantiacus) 		5 / 11 ASP A 129
VAL A 116
ALA A 117
PHE A 112
GLY A 152
 None
 1.26A 4mmaA-1gzjA:
undetectable		 4mmaA-1gzjA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 1gzj EGI
(Thermoascus
aurantiacus) 		4 / 6 LEU A 145
ASN A 146
MET A  62
ILE A 163
 None
 1.12A 4okxA-1gzjA:
undetectable		 4okxA-1gzjA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1gzj EGI
(Thermoascus
aurantiacus) 		4 / 8 ILE A 237
GLY A 269
PHE A 284
ASN A  46
 None
 0.81A 5hieD-1gzjA:
undetectable		 5hieD-1gzjA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 1gzj EGI
(Thermoascus
aurantiacus) 		5 / 12 GLY A 218
TYR A 259
TYR A 304
PHE A   7
LEU A 301
 None
 1.42A 5kklB-1gzjA:
undetectable		 5kklB-1gzjA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1gzj EGI
(Thermoascus
aurantiacus) 		3 / 3 THR A 171
GLU A 166
HIS A  93
 None
 0.81A 5xioA-1gzjA:
undetectable		 5xioA-1gzjA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1gzj EGI
(Thermoascus
aurantiacus) 		3 / 3 THR A 171
GLU A 166
HIS A  93
 None
 0.83A 5xiqB-1gzjA:
undetectable		 5xiqB-1gzjA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1gzj EGI
(Thermoascus
aurantiacus) 		3 / 3 THR A 171
GLU A 166
HIS A  93
 None
 0.84A 5xiqD-1gzjA:
undetectable		 5xiqD-1gzjA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1gzj EGI
(Thermoascus
aurantiacus) 		5 / 12 ARG A  49
GLU A 166
TYR A 200
ASN A 132
HIS A  93
 None
 1.47A 6b1eB-1gzjA:
undetectable		 6b1eB-1gzjA:
17.96