SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		3 / 3 PHE A 426
TYR A 438
PRO A 428
 None
 0.77A 1mcnA-1gzkA:
undetectable
1mcnB-1gzkA:
undetectable
1mcnP-1gzkA:
undetectable		 1mcnA-1gzkA:
20.44
1mcnB-1gzkA:
20.44
1mcnP-1gzkA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		3 / 3 THR A 372
LEU A 373
LEU A 380
 None
 0.64A 1mz9C-1gzkA:
undetectable		 1mz9C-1gzkA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		4 / 7 LEU A 380
PHE A 408
ARG A 251
MET A 344
 None
 1.03A 2eikA-1gzkA:
0.0
2eikJ-1gzkA:
undetectable		 2eikA-1gzkA:
20.42
2eikJ-1gzkA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		4 / 7 LEU A 380
PHE A 408
ARG A 251
MET A 344
 None
 1.02A 2zxwN-1gzkA:
0.0
2zxwW-1gzkA:
undetectable		 2zxwN-1gzkA:
20.42
2zxwW-1gzkA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 GLY A 346
CYH A 345
ALA A 252
LEU A 381
LEU A 384
 None
 1.27A 3adsB-1gzkA:
undetectable		 3adsB-1gzkA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 SER A 261
PHE A 409
PHE A 254
ILE A 412
ASP A 284
 None
 1.42A 3aocC-1gzkA:
0.0		 3aocC-1gzkA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		4 / 8 GLU A 249
SER A 374
VAL A 403
HIS A 406
 None
 1.15A 3b9lA-1gzkA:
0.9		 3b9lA-1gzkA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 LEU A 158
VAL A 166
LYS A 181
ASP A 275
 None
 0.78A 3cs9D-1gzkA:
20.5		 3cs9D-1gzkA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		4 / 5 PHE A 439
ALA A 232
THR A 213
LEU A 158
 None
 1.02A 3t3zC-1gzkA:
undetectable		 3t3zC-1gzkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 GLY A 161
GLY A 164
VAL A 166
ALA A 179
LYS A 181
LEU A 183
 None
 0.63A 3v5wA-1gzkA:
10.2		 3v5wA-1gzkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		6 / 10 LEU A 158
GLY A 159
GLY A 161
VAL A 166
ALA A 179
TYR A 231
 None
 0.50A 4ckjA-1gzkA:
21.8		 4ckjA-1gzkA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 LEU A 158
TYR A 231
THR A 292
GLY A 295
 None
 1.01A 4l39A-1gzkA:
0.0		 4l39A-1gzkA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		4 / 7 VAL A 166
ALA A 179
LEU A 183
MET A 229
 None
 0.26A 4l9iA-1gzkA:
9.5		 4l9iA-1gzkA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		5 / 8 GLY A 161
VAL A 166
ALA A 179
LYS A 181
MET A 229
 None
 0.64A 4l9iB-1gzkA:
27.1		 4l9iB-1gzkA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 CYH A 345
LEU A 381
LEU A 373
ALA A 377
VAL A 246
 None
 1.04A 4p65C-1gzkA:
undetectable
4p65D-1gzkA:
undetectable
4p65J-1gzkA:
undetectable
4p65L-1gzkA:
undetectable		 4p65C-1gzkA:
7.94
4p65D-1gzkA:
10.13
4p65J-1gzkA:
10.13
4p65L-1gzkA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 VAL A 246
CYH A 345
LEU A 381
LEU A 373
ALA A 377
 None
 1.00A 4p65B-1gzkA:
undetectable
4p65D-1gzkA:
undetectable
4p65G-1gzkA:
undetectable
4p65H-1gzkA:
undetectable		 4p65B-1gzkA:
10.13
4p65D-1gzkA:
10.13
4p65G-1gzkA:
7.94
4p65H-1gzkA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 VAL A 246
CYH A 345
LEU A 381
LEU A 373
ALA A 377
 None
 1.01A 4p65B-1gzkA:
undetectable
4p65D-1gzkA:
undetectable
4p65I-1gzkA:
undetectable
4p65J-1gzkA:
undetectable		 4p65B-1gzkA:
10.13
4p65D-1gzkA:
10.13
4p65I-1gzkA:
7.94
4p65J-1gzkA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 VAL A 246
CYH A 345
LEU A 381
LEU A 373
ALA A 377
 None
 1.05A 4p65F-1gzkA:
undetectable
4p65H-1gzkA:
undetectable
4p65K-1gzkA:
undetectable
4p65L-1gzkA:
undetectable		 4p65F-1gzkA:
10.13
4p65H-1gzkA:
10.13
4p65K-1gzkA:
7.94
4p65L-1gzkA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		4 / 8 LEU A 158
VAL A 166
LYS A 181
ALA A 232
 None
 0.85A 4qrcA-1gzkA:
22.2		 4qrcA-1gzkA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		4 / 4 CYH A 345
LEU A 381
LEU A 373
ALA A 377
 None
 0.91A 5hpuA-1gzkA:
undetectable
5hpuB-1gzkA:
undetectable		 5hpuA-1gzkA:
7.94
5hpuB-1gzkA:
8.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		4 / 7 GLY A 159
GLY A 161
LYS A 181
LEU A 183
 None
 0.37A 5izfA-1gzkA:
30.6		 5izfA-1gzkA:
39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		5 / 7 GLY A 159
GLY A 161
GLY A 164
VAL A 166
LEU A 183
 None
 0.32A 5izjB-1gzkA:
29.8		 5izjB-1gzkA:
39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		5 / 7 GLY A 159
GLY A 161
VAL A 166
LYS A 181
LEU A 183
 None
 0.32A 5izjA-1gzkA:
30.1		 5izjA-1gzkA:
39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		4 / 7 GLY A 159
GLY A 161
VAL A 166
LYS A 181
 None
 0.37A 5j5xA-1gzkA:
31.0		 5j5xA-1gzkA:
39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ALA A 257
GLY A 256
ASN A 280
GLU A 279
LEU A 237
 None
 1.09A 5nwuA-1gzkA:
0.0		 5nwuA-1gzkA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 MET A 180
MET A 229
ALA A 179
TYR A 177
THR A 436
 None
 1.09A 6hu9N-1gzkA:
0.5		 6hu9N-1gzkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 ILE A 276
HIS A 267
ASP A 399
LEU A 384
GLY A 395
 None
 1.20A 6ieyA-1gzkA:
undetectable
6ieyB-1gzkA:
undetectable		 6ieyA-1gzkA:
19.14
6ieyB-1gzkA:
19.14