SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 HIS A 173
PHE A 241
GLY A 268
HIS A 270
ASP A 139
 CO  A1353 (-3.2A)
None
None
CO  A1354 (-3.3A)
CO  A1353 (-1.8A)
 1.23A 1a4lD-1h0nA:
undetectable		 1a4lD-1h0nA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 PHE A 237
PHE A 241
GLY A 268
HIS A 270
ASP A 139
 None
None
None
CO  A1354 (-3.3A)
CO  A1353 (-1.8A)
 1.34A 1a4lD-1h0nA:
undetectable		 1a4lD-1h0nA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 LEU A 256
ARG A 125
LEU A 132
ALA A 136
ILE A 181
 None
 1.04A 1fk6A-1h0nA:
1.4		 1fk6A-1h0nA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 11 ASP A 139
GLU A 170
HIS A 173
PHE A 241
ILE A 263
 CO  A1353 (-1.8A)
CO  A1354 ( 2.5A)
CO  A1353 (-3.2A)
None
None
 0.72A 1rnrA-1h0nA:
31.2		 1rnrA-1h0nA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		6 / 11 GLU A 170
HIS A 173
GLU A 233
PHE A 241
ILE A 263
GLU A 267
 CO  A1354 ( 2.5A)
CO  A1353 (-3.2A)
CO  A1354 (-1.7A)
None
None
CO  A1354 ( 2.3A)
 0.53A 1rnrA-1h0nA:
31.2		 1rnrA-1h0nA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		6 / 11 HIS A 173
GLU A 233
SER A 240
PHE A 241
ILE A 263
GLU A 267
 CO  A1353 (-3.2A)
CO  A1354 (-1.7A)
None
None
None
CO  A1354 ( 2.3A)
 0.87A 1rnrA-1h0nA:
31.2		 1rnrA-1h0nA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 ASP A 139
GLU A 170
HIS A 173
PHE A 241
ILE A 263
 CO  A1353 (-1.8A)
CO  A1354 ( 2.5A)
CO  A1353 (-3.2A)
None
None
 0.70A 1rnrB-1h0nA:
31.3		 1rnrB-1h0nA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 ASP A 139
GLU A 170
HIS A 173
TYR A 177
ILE A 263
 CO  A1353 (-1.8A)
CO  A1354 ( 2.5A)
CO  A1353 (-3.2A)
None
None
 0.68A 1rnrB-1h0nA:
31.3		 1rnrB-1h0nA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		6 / 12 GLU A 170
HIS A 173
GLU A 233
PHE A 241
ILE A 263
GLU A 267
 CO  A1354 ( 2.5A)
CO  A1353 (-3.2A)
CO  A1354 (-1.7A)
None
None
CO  A1354 ( 2.3A)
 0.50A 1rnrB-1h0nA:
31.3		 1rnrB-1h0nA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		6 / 12 GLU A 170
HIS A 173
TYR A 177
GLU A 233
ILE A 263
GLU A 267
 CO  A1354 ( 2.5A)
CO  A1353 (-3.2A)
None
CO  A1354 (-1.7A)
None
CO  A1354 ( 2.3A)
 0.69A 1rnrB-1h0nA:
31.3		 1rnrB-1h0nA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 10 ALA A 231
PHE A 229
TRP A 214
ALA A 211
LEU A 212
 None
 1.05A 2bxqA-1h0nA:
undetectable		 2bxqA-1h0nA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 VAL A 131
PHE A 127
THR A 257
VAL A 311
LEU A 305
 None
 1.20A 2jn3A-1h0nA:
undetectable		 2jn3A-1h0nA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 LEU A 336
PHE A 273
LEU A 276
GLY A 223
ALA A 230
 None
 1.05A 3tbgB-1h0nA:
0.6		 3tbgB-1h0nA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 PHE A 245
SER A 259
HIS A 173
TYR A 177
LEU A 132
 None
None
CO  A1353 (-3.2A)
None
None
 1.25A 3vn2A-1h0nA:
0.0		 3vn2A-1h0nA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 LEU A  73
PHE A 273
ILE A  91
GLU A 153
LEU A  74
 None
 0.97A 4r88A-1h0nA:
undetectable		 4r88A-1h0nA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 LEU A  73
PHE A 273
ILE A  91
GLU A 153
LEU A  74
 None
 0.96A 4r88B-1h0nA:
undetectable		 4r88B-1h0nA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 LEU A  73
PHE A 273
ILE A  91
GLU A 153
LEU A  74
 None
 0.95A 4r88C-1h0nA:
undetectable		 4r88C-1h0nA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 LEU A  73
PHE A 273
ILE A  91
GLU A 153
LEU A  74
 None
 0.95A 4r88D-1h0nA:
undetectable		 4r88D-1h0nA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 LEU A  73
PHE A 273
ILE A  91
GLU A 153
LEU A  74
 None
 0.98A 4r88E-1h0nA:
undetectable		 4r88E-1h0nA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 LEU A  73
PHE A 273
ILE A  91
GLU A 153
LEU A  74
 None
 0.97A 4r88F-1h0nA:
undetectable		 4r88F-1h0nA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		4 / 7 GLY A 234
PHE A 304
LEU A 305
GLU A 267
 None
None
None
CO  A1354 ( 2.3A)
 0.81A 5izfA-1h0nA:
undetectable		 5izfA-1h0nA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 ALA A 274
GLU A 153
GLN A 155
LEU A  74
GLU A  76
 None
 1.26A 5nwuA-1h0nA:
0.0		 5nwuA-1h0nA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		4 / 6 TYR A  95
ASP A  90
TRP A  92
HIS A  89
 None
 1.42A 5ov9A-1h0nA:
undetectable		 5ov9A-1h0nA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		4 / 7 TYR A  95
ASP A  90
TRP A  92
HIS A  89
 None
 1.42A 5ov9B-1h0nA:
undetectable		 5ov9B-1h0nA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		3 / 3 ARG A 125
PHE A 135
LEU A 194
 None
 0.44A 5veuA-1h0nA:
0.0		 5veuA-1h0nA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
(Mus
musculus) 		5 / 12 VAL A 232
GLY A 234
SER A 238
PHE A 134
VAL A 204
 None
 1.32A 6a94A-1h0nA:
4.1		 6a94A-1h0nA:
23.70