SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5
(Caenorhabditis
elegans) 		3 / 3 GLU A 110
LYS A  51
VAL A  53
 None
 0.79A 1l2iA-1h0pA:
0.0		 1l2iA-1h0pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5
(Caenorhabditis
elegans) 		3 / 3 THR A  56
PRO A  54
THR A  58
 None
 0.70A 209dC-1h0pA:
undetectable		 209dC-1h0pA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5
(Caenorhabditis
elegans) 		3 / 3 TYR A  72
GLY A  74
PHE A  91
 None
 0.68A 2m2pB-1h0pA:
undetectable		 2m2pB-1h0pA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5
(Caenorhabditis
elegans) 		5 / 10 GLY A  71
TYR A  72
GLY A  74
PHE A  32
ILE A 183
 None
 1.50A 2y7pA-1h0pA:
undetectable		 2y7pA-1h0pA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5
(Caenorhabditis
elegans) 		5 / 12 ALA A  57
GLY A  47
LEU A 157
TRP A 121
GLU A 200
 None
 0.89A 4lg1A-1h0pA:
undetectable		 4lg1A-1h0pA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5
(Caenorhabditis
elegans) 		5 / 12 ALA A  57
GLY A  47
LEU A 157
TRP A 121
GLU A 200
 None
 0.86A 4lg1B-1h0pA:
undetectable		 4lg1B-1h0pA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5
(Caenorhabditis
elegans) 		4 / 5 PHE A  49
HIS A 116
LEU A 122
PRO A  24
 None
 1.41A 5csyB-1h0pA:
undetectable		 5csyB-1h0pA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5
(Caenorhabditis
elegans) 		4 / 8 VAL A  30
ILE A  46
ILE A 166
PHE A 136
 None
 0.75A 5hw8H-1h0pA:
undetectable		 5hw8H-1h0pA:
22.95