SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h1a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)		 1h1a ENDO-1,4-BETA-XYLANA
SE
(Chaetomium
thermophilum) 		5 / 12 HIS A 156
ARG A 161
GLN A 173
VAL A  90
TYR A  88
 None
 1.34A 2a5hB-1h1aA:
undetectable		 2a5hB-1h1aA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YK1_H_NCTH300_1
(FAB FRAGMENT, HEAVY
CHAIN
FAB FRAGMENT, LIGHT
CHAIN)		 1h1a ENDO-1,4-BETA-XYLANA
SE
(Chaetomium
thermophilum) 		5 / 10 ILE A 174
GLY A  48
SER A  17
VAL A  47
TYR A  88
 None
 1.44A 2yk1H-1h1aA:
0.0
2yk1L-1h1aA:
2.4		 2yk1H-1h1aA:
27.36
2yk1L-1h1aA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 1h1a ENDO-1,4-BETA-XYLANA
SE
(Chaetomium
thermophilum) 		4 / 7 TYR A  89
TYR A  78
TYR A 172
TYR A  36
 None
 1.29A 3ku9B-1h1aA:
undetectable		 3ku9B-1h1aA:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1h1a ENDO-1,4-BETA-XYLANA
SE
(Chaetomium
thermophilum) 		5 / 8 THR A 101
TYR A 119
THR A 121
GLN A 137
TRP A 139
 None
 0.90A 5tzoA-1h1aA:
28.8		 5tzoA-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1h1a ENDO-1,4-BETA-XYLANA
SE
(Chaetomium
thermophilum) 		5 / 8 TYR A 119
THR A 121
ARG A 123
GLN A 137
TRP A 139
 None
None
GOL  A1196 (-2.8A)
None
None
 1.28A 5tzoA-1h1aA:
28.8		 5tzoA-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1h1a ENDO-1,4-BETA-XYLANA
SE
(Chaetomium
thermophilum) 		7 / 12 VAL A  47
TRP A  80
TYR A  89
PRO A 127
TRP A 139
TYR A 172
GLY A 179
 None
None
None
GOL  A1196 (-4.0A)
None
None
None
 0.72A 5tzoA-1h1aA:
28.8		 5tzoA-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1h1a ENDO-1,4-BETA-XYLANA
SE
(Chaetomium
thermophilum) 		6 / 12 VAL A  47
TRP A  80
TYR A  89
TRP A 139
TYR A 172
GLY A 179
 None
 0.69A 5tzoB-1h1aA:
28.8		 5tzoB-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1h1a ENDO-1,4-BETA-XYLANA
SE
(Chaetomium
thermophilum) 		5 / 8 THR A 101
TYR A 119
THR A 121
GLN A 137
TRP A 139
 None
 0.83A 5tzoB-1h1aA:
28.8		 5tzoB-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1h1a ENDO-1,4-BETA-XYLANA
SE
(Chaetomium
thermophilum) 		5 / 8 TYR A 119
THR A 121
ARG A 123
GLN A 137
TRP A 139
 None
None
GOL  A1196 (-2.8A)
None
None
 1.14A 5tzoB-1h1aA:
28.8		 5tzoB-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1h1a ENDO-1,4-BETA-XYLANA
SE
(Chaetomium
thermophilum) 		7 / 12 VAL A  47
TRP A  80
TYR A  89
PRO A 127
TRP A 139
TYR A 172
GLY A 179
 None
None
None
GOL  A1196 (-4.0A)
None
None
None
 0.79A 5tzoC-1h1aA:
28.7		 5tzoC-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1h1a ENDO-1,4-BETA-XYLANA
SE
(Chaetomium
thermophilum) 		5 / 8 THR A 101
TYR A 119
THR A 121
GLN A 137
TRP A 139
 None
 0.88A 5tzoC-1h1aA:
28.7		 5tzoC-1h1aA:
52.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1h1a ENDO-1,4-BETA-XYLANA
SE
(Chaetomium
thermophilum) 		5 / 8 TYR A 119
THR A 121
ARG A 123
GLN A 137
TRP A 139
 None
None
GOL  A1196 (-2.8A)
None
None
 1.22A 5tzoC-1h1aA:
28.7		 5tzoC-1h1aA:
52.28