SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_B_ADNB501_1
(HYPOTHETICAL PROTEIN
PH0463)		 1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 11 ILE A  65
VAL A 214
ASN A 232
TYR A 224
ASN A 225
 None
 1.41A 1wu8B-1h1cA:
0.4
1wu8C-1h1cA:
0.6		 1wu8B-1h1cA:
24.49
1wu8C-1h1cA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 LEU A 328
ASN A 324
ARG A 264
 None
 0.77A 2qhfA-1h1cA:
0.0		 2qhfA-1h1cA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 PHE A 200
VAL A  79
LEU A  74
ILE A  65
THR A  71
 None
 1.38A 3elzC-1h1cA:
undetectable		 3elzC-1h1cA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A 137
ILE A 163
VAL A 142
VAL A 100
 None
 0.71A 3fi0I-1h1cA:
undetectable		 3fi0I-1h1cA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 PRO A 147
SER A 279
ASN A 149
 None
None
PLP  A1202 (-4.1A)
 0.85A 3lslG-1h1cA:
0.0		 3lslG-1h1cA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA598_0
(LACTOPEROXIDASE)		 1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 5 PHE A 179
ARG A 262
GLU A 261
PRO A  30
 None
 1.38A 3r4xA-1h1cA:
0.0		 3r4xA-1h1cA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 THR A 105
ASN A 148
ASP A 173
ILE A 197
 None
None
PLP  A1202 (-2.9A)
None
 1.26A 3w9tB-1h1cA:
0.0		 3w9tB-1h1cA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ARG A  19
GLU A  28
SER A 107
ARG A 308
TYR A  23
 None
 1.44A 4b7qB-1h1cA:
undetectable		 4b7qB-1h1cA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 LYS A 202
THR A 199
ILE A  88
 PLP  A1202 (-1.3A)
PLP  A1202 (-3.3A)
None
 0.84A 4e0fB-1h1cA:
0.6		 4e0fB-1h1cA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 ALA A  25
ASN A  27
ARG A 308
ARG A 315
 None
 1.28A 5db5A-1h1cA:
22.2
5db5B-1h1cA:
21.9		 5db5A-1h1cA:
22.17
5db5B-1h1cA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 GLY A 212
GLY A  84
SER A 205
ALA A 241
 PLP  A1202 ( 4.9A)
PLP  A1202 (-3.5A)
None
None
 0.77A 5o96C-1h1cA:
undetectable		 5o96C-1h1cA:
20.45