SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		5 / 11 SER A 202
GLY A 182
LEU A 216
GLY A 200
MET A  27
 None
None
None
SO4  A1224 (-3.5A)
None
 1.32A 1iolA-1h1yA:
undetectable		 1iolA-1h1yA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		3 / 3 LEU A  35
LEU A  66
SER A  88
 None
 0.69A 1tlmA-1h1yA:
0.0		 1tlmA-1h1yA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		4 / 5 LEU A 216
PRO A 209
VAL A 212
ILE A 213
 None
 1.00A 2aoiB-1h1yA:
undetectable		 2aoiB-1h1yA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		4 / 7 ARG A 114
LEU A 140
VAL A 198
MET A  12
 None
 1.27A 2hrcA-1h1yA:
undetectable		 2hrcA-1h1yA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		4 / 8 VAL A 163
ILE A 197
VAL A 220
GLY A 193
 None
 0.88A 3hjoB-1h1yA:
undetectable		 3hjoB-1h1yA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		4 / 6 PHE A  90
TYR A  78
VAL A  96
THR A  73
 None
 1.27A 3ltwA-1h1yA:
undetectable		 3ltwA-1h1yA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		5 / 12 ASP A  38
SER A  11
LEU A  13
GLN A 153
VAL A  45
 None
SO4  A1224 ( 4.6A)
None
None
None
 1.26A 3mbhC-1h1yA:
undetectable		 3mbhC-1h1yA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		3 / 3 HIS A  69
HIS A  93
MET A  71
 None
 0.64A 3mihA-1h1yA:
undetectable		 3mihA-1h1yA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		3 / 3 SER A 118
ASP A  67
ASP A  33
 None
 0.72A 3uj7A-1h1yA:
undetectable		 3uj7A-1h1yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		5 / 12 LEU A  82
ILE A  55
ILE A  39
THR A  91
ALA A  87
 None
 1.01A 4enhA-1h1yA:
0.0		 4enhA-1h1yA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		4 / 8 GLY A 151
GLY A 180
LEU A 181
VAL A 198
 SO4  A1224 (-3.6A)
SO4  A1224 (-3.7A)
None
None
 0.86A 4fgzA-1h1yA:
undetectable		 4fgzA-1h1yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		4 / 8 GLY A 151
GLY A 180
LEU A 181
VAL A 198
 SO4  A1224 (-3.6A)
SO4  A1224 (-3.7A)
None
None
 0.87A 4fgzB-1h1yA:
undetectable		 4fgzB-1h1yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		3 / 3 ARG A 120
ASP A  41
ASP A  77
 None
 0.90A 4kicB-1h1yA:
1.0		 4kicB-1h1yA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		3 / 3 SER A 118
ASP A  67
ASP A  33
 None
 0.71A 4mwzA-1h1yA:
undetectable		 4mwzA-1h1yA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		4 / 6 LEU A 166
GLU A 161
VAL A 188
ALA A 189
 None
 0.85A 4nkxA-1h1yA:
0.0		 4nkxA-1h1yA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		4 / 8 ASN A 100
MET A 113
LEU A  70
ILE A  94
 None
 1.05A 4ok1A-1h1yA:
undetectable		 4ok1A-1h1yA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		4 / 6 THR A 123
GLU A 127
THR A  91
HIS A  69
 None
 1.14A 4pgfA-1h1yA:
undetectable		 4pgfA-1h1yA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		4 / 8 VAL A 163
ILE A 197
HIS A  36
LEU A 181
 None
 0.78A 4qrcA-1h1yA:
undetectable		 4qrcA-1h1yA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		3 / 3 VAL A 146
SER A 201
MET A  12
 None
SO4  A1224 (-3.1A)
None
 0.94A 5ikqA-1h1yA:
0.0		 5ikqA-1h1yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		5 / 12 VAL A 220
MET A 160
PHE A 155
VAL A 143
LEU A 181
 None
 1.19A 5tudD-1h1yA:
undetectable		 5tudD-1h1yA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		4 / 4 ILE A  55
LEU A  35
HIS A  61
ALA A  24
 None
 1.02A 6ck2C-1h1yA:
undetectable
6ck2D-1h1yA:
undetectable		 6ck2C-1h1yA:
8.21
6ck2D-1h1yA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE
(Oryza
sativa) 		3 / 3 ASP A 178
SER A 201
SER A  14
 SO4  A1224 ( 4.9A)
SO4  A1224 (-3.1A)
SO4  A1224 ( 4.1A)
 0.75A 6mxtA-1h1yA:
undetectable		 6mxtA-1h1yA:
18.78