SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 1h2a HYDROGENASE
(Desulfovibrio
vulgaris) 		4 / 8 LEU S  12
ALA S  72
LEU S 176
THR S 113
 None
None
None
SF4  S1001 (-4.7A)
 0.90A 1dvtA-1h2aS:
0.0
1dvtB-1h2aS:
0.0		 1dvtA-1h2aS:
17.42
1dvtB-1h2aS:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 1h2a HYDROGENASE
(Desulfovibrio
vulgaris) 		3 / 3 THR S 128
THR S  80
PRO S  79
 None
 0.84A 209dC-1h2aS:
undetectable		 209dC-1h2aS:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 1h2a HYDROGENASE
(Desulfovibrio
vulgaris) 		3 / 3 THR S  80
PRO S  79
THR S 128
 None
 0.90A 316dC-1h2aS:
undetectable		 316dC-1h2aS:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 1h2a HYDROGENASE
(Desulfovibrio
vulgaris) 		5 / 8 ALA S 144
ILE S 145
ASN S 146
PRO S 179
PRO S 171
 None
 1.35A 3fxrA-1h2aS:
undetectable		 3fxrA-1h2aS:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 1h2a HYDROGENASE
(Desulfovibrio
vulgaris) 		4 / 8 ILE S  32
HIS S  45
HIS S  13
THR S  18
 None
 0.91A 4n16A-1h2aS:
undetectable		 4n16A-1h2aS:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1h2a HYDROGENASE
(Desulfovibrio
vulgaris) 		5 / 10 LEU S 137
GLY S  77
GLY S 132
ILE S  97
LEU S  12
 None
 1.01A 5l0zB-1h2aS:
undetectable		 5l0zB-1h2aS:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1h2a HYDROGENASE
(Desulfovibrio
vulgaris) 		5 / 12 ILE S  71
THR S 160
ASN S 156
ILE S 145
ALA S 144
 None
 1.11A 5lg3E-1h2aS:
0.0		 5lg3E-1h2aS:
19.06