SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 8 GLU A 314
LEU A 126
MET A 121
GLU A 119
ALA A 114
 None
 1.40A 1a29A-1h2bA:
undetectable		 1a29A-1h2bA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 ALA A 176
GLY A 170
ILE A 201
VAL A 284
 None
None
None
NAJ  A1361 (-4.1A)
 0.80A 1d4sB-1h2bA:
undetectable		 1d4sB-1h2bA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 HIS A 200
GLY A 353
LEU A 224
GLU A 228
ALA A 227
 None
 1.14A 1mjqC-1h2bA:
undetectable
1mjqD-1h2bA:
undetectable		 1mjqC-1h2bA:
14.67
1mjqD-1h2bA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 HIS A 200
GLY A 353
LEU A 224
GLU A 228
ALA A 227
 None
 1.14A 1mjqI-1h2bA:
undetectable
1mjqJ-1h2bA:
undetectable		 1mjqI-1h2bA:
14.67
1mjqJ-1h2bA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 6 VAL A  61
GLU A  23
LEU A  21
ARG A  29
 None
 1.05A 1s8fB-1h2bA:
2.5		 1s8fB-1h2bA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 ALA A 355
GLY A  52
LEU A 357
PHE A 137
VAL A  61
 None
 1.31A 1vpoH-1h2bA:
undetectable
1vpoL-1h2bA:
0.0		 1vpoH-1h2bA:
19.33
1vpoL-1h2bA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 10 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.93A 2aquA-1h2bA:
undetectable		 2aquA-1h2bA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 4 VAL A 351
LEU A 336
ILE A  30
LEU A  28
 None
 1.02A 2byoA-1h2bA:
0.0		 2byoA-1h2bA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 11 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.91A 2fxeB-1h2bA:
undetectable		 2fxeB-1h2bA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.96A 2hs2A-1h2bA:
undetectable		 2hs2A-1h2bA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.85A 2o4sA-1h2bA:
undetectable		 2o4sA-1h2bA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 ILE A  48
ALA A 138
GLY A  78
VAL A  53
GLY A  52
 None
 0.97A 2qe6B-1h2bA:
4.1		 2qe6B-1h2bA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.89A 2r5pB-1h2bA:
undetectable		 2r5pB-1h2bA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 5 TYR A  24
LEU A  73
LYS A  72
HIS A  66
 None
 1.47A 2wekB-1h2bA:
32.5		 2wekB-1h2bA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 LEU A 315
THR A 172
TRP A  65
HIS A  59
 None
NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
 0.96A 2y69C-1h2bA:
0.0
2y69N-1h2bA:
0.0
2y69P-1h2bA:
undetectable		 2y69C-1h2bA:
19.62
2y69N-1h2bA:
21.42
2y69P-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 ASP A  57
ILE A 339
LEU A 357
GLY A 136
ASN A  81
 None
 1.11A 2ycjA-1h2bA:
undetectable		 2ycjA-1h2bA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 9 ALA A 216
VAL A 214
VAL A 195
GLY A 199
ALA A 227
 None
 0.89A 2z0yB-1h2bA:
undetectable		 2z0yB-1h2bA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 9 VAL A 203
GLY A 197
GLY A 196
LEU A 205
ALA A 173
 None
NAJ  A1361 (-3.5A)
NAJ  A1361 (-3.2A)
None
None
 0.90A 2z0yB-1h2bA:
undetectable		 2z0yB-1h2bA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 5 VAL A 257
VAL A 190
THR A 271
THR A 183
 None
 1.28A 3bjwG-1h2bA:
0.0		 3bjwG-1h2bA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		3 / 3 GLY A 136
GLY A 130
GLY A  78
 None
 0.42A 3bogC-1h2bA:
0.0		 3bogC-1h2bA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 HIS A  79
ASP A 168
THR A 172
LEU A 131
MET A 121
 ZN  A1362 ( 3.2A)
ZN  A1362 (-2.7A)
NAJ  A1361 (-3.4A)
OCA  A1360 (-4.8A)
None
 1.47A 3ce6D-1h2bA:
4.7		 3ce6D-1h2bA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.89A 3d1xB-1h2bA:
undetectable		 3d1xB-1h2bA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 11 LEU A 226
GLY A 231
ALA A 232
ASP A 233
VAL A 190
 None
 1.10A 3ebzB-1h2bA:
undetectable		 3ebzB-1h2bA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 10 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.95A 3ekyA-1h2bA:
undetectable		 3ekyA-1h2bA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 11 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.93A 3em4A-1h2bA:
undetectable		 3em4A-1h2bA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.88A 3jvyA-1h2bA:
undetectable		 3jvyA-1h2bA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.92A 3jvyB-1h2bA:
undetectable		 3jvyB-1h2bA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 LEU A 290
LEU A 281
SER A 307
ASP A 260
 None
 0.99A 3lm8A-1h2bA:
2.8
3lm8C-1h2bA:
3.6		 3lm8A-1h2bA:
20.77
3lm8C-1h2bA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 GLU A  80
PHE A 128
ARG A 354
ASP A  57
 None
OCA  A1360 (-4.5A)
NAJ  A1361 (-3.1A)
None
 1.10A 3mjrD-1h2bA:
undetectable		 3mjrD-1h2bA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.84A 3nu3A-1h2bA:
undetectable		 3nu3A-1h2bA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		3 / 3 GLY A  94
ILE A 149
VAL A 148
 None
 0.51A 3nv6A-1h2bA:
undetectable		 3nv6A-1h2bA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.87A 3oxcA-1h2bA:
undetectable		 3oxcA-1h2bA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 9 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.94A 3oxvA-1h2bA:
undetectable		 3oxvA-1h2bA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 10 LEU A 226
GLY A 231
ALA A 232
ASP A 233
ILE A 215
 None
 0.94A 3oxwC-1h2bA:
undetectable		 3oxwC-1h2bA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 9 LYS A 220
LYS A 223
VAL A 195
GLY A 196
LEU A 217
 None
NAJ  A1361 (-4.1A)
None
NAJ  A1361 (-3.2A)
None
 1.42A 4b3oA-1h2bA:
undetectable		 4b3oA-1h2bA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 GLY A 197
GLY A 170
GLU A  80
VAL A 309
 NAJ  A1361 (-3.5A)
None
None
NAJ  A1361 (-3.7A)
 0.90A 4fgzA-1h2bA:
6.1		 4fgzA-1h2bA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 LEU A 281
VAL A 257
ALA A 212
VAL A 195
VAL A 246
 None
 1.25A 4ib4A-1h2bA:
undetectable		 4ib4A-1h2bA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 THR A 172
ALA A 169
ASP A 168
ILE A 192
GLY A 194
 NAJ  A1361 (-3.4A)
None
ZN  A1362 (-2.7A)
None
NAJ  A1361 (-3.6A)
 1.01A 4xi3B-1h2bA:
undetectable		 4xi3B-1h2bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 THR A 172
TRP A  65
HIS A  59
LEU A 315
 NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
None
 1.09A 5b1bA-1h2bA:
0.0
5b1bC-1h2bA:
0.0
5b1bP-1h2bA:
0.0		 5b1bA-1h2bA:
21.42
5b1bC-1h2bA:
19.62
5b1bP-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 ALA A 266
THR A 267
TYR A 270
VAL A 219
 NAJ  A1361 ( 4.1A)
NAJ  A1361 (-4.6A)
None
NAJ  A1361 (-4.4A)
 0.83A 5ecnA-1h2bA:
0.5		 5ecnA-1h2bA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 GLY A  52
ALA A  51
GLY A 130
VAL A  46
ILE A  48
 None
 0.86A 5kqxA-1h2bA:
undetectable		 5kqxA-1h2bA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 LEU A 198
THR A 172
VAL A 309
SER A 307
THR A 271
 NAJ  A1361 (-3.7A)
NAJ  A1361 (-3.4A)
NAJ  A1361 (-3.7A)
None
None
 1.17A 5v1tA-1h2bA:
undetectable		 5v1tA-1h2bA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 8 THR A 172
TRP A  65
HIS A  59
LEU A 315
 NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
None
 1.02A 5w97A-1h2bA:
0.0
5w97C-1h2bA:
0.0
5w97c-1h2bA:
0.0		 5w97A-1h2bA:
21.42
5w97C-1h2bA:
19.62
5w97c-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 LEU A 315
THR A 172
TRP A  65
HIS A  59
 None
NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
 1.02A 5w97C-1h2bA:
undetectable
5w97a-1h2bA:
0.0
5w97c-1h2bA:
undetectable		 5w97C-1h2bA:
19.62
5w97a-1h2bA:
21.42
5w97c-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 LEU A 315
THR A 172
TRP A  65
HIS A  59
 None
NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
 1.08A 5wauC-1h2bA:
0.0
5waua-1h2bA:
undetectable
5wauc-1h2bA:
0.0		 5wauC-1h2bA:
19.62
5waua-1h2bA:
21.42
5wauc-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 THR A 172
TRP A  65
HIS A  59
LEU A 315
 NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
None
 1.07A 5x1bA-1h2bA:
0.0
5x1bC-1h2bA:
0.0
5x1bP-1h2bA:
undetectable		 5x1bA-1h2bA:
21.42
5x1bC-1h2bA:
19.62
5x1bP-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 THR A 172
TRP A  65
HIS A  59
LEU A 315
 NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
None
 1.07A 5x1fA-1h2bA:
undetectable
5x1fC-1h2bA:
0.0
5x1fP-1h2bA:
0.0		 5x1fA-1h2bA:
21.42
5x1fC-1h2bA:
19.62
5x1fP-1h2bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 5 VAL A 309
LEU A 198
VAL A 329
LEU A 205
 NAJ  A1361 (-3.7A)
NAJ  A1361 (-3.7A)
None
None
 0.84A 6bqgA-1h2bA:
undetectable		 6bqgA-1h2bA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		3 / 3 ARG A 240
ARG A 239
ASP A 237
 None
 0.94A 6d8pA-1h2bA:
2.3		 6d8pA-1h2bA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 VAL A  33
ASP A  32
GLU A  31
ARG A  47
LEU A 336
 None
 1.19A 6ew0F-1h2bA:
2.2		 6ew0F-1h2bA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 VAL A  33
ASP A  32
GLU A  31
ARG A  47
LEU A 336
 None
 1.19A 6ew0G-1h2bA:
3.2		 6ew0G-1h2bA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		5 / 12 HIS A  79
ASP A 168
THR A 172
LEU A 131
MET A 121
 ZN  A1362 ( 3.2A)
ZN  A1362 (-2.7A)
NAJ  A1361 (-3.4A)
OCA  A1360 (-4.8A)
None
 1.48A 6f3nB-1h2bA:
6.4		 6f3nB-1h2bA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 ASP A 332
GLU A 338
ASP A 341
GLU A 344
 ZN  A1363 (-2.1A)
None
None
None
 1.33A 6mn5B-1h2bA:
2.6		 6mn5B-1h2bA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 6 ASP A 332
GLU A 338
ASP A 341
GLU A 344
 ZN  A1363 (-2.1A)
None
None
None
 1.34A 6mn5C-1h2bA:
2.4		 6mn5C-1h2bA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 6 ASP A 332
GLU A 338
ASP A 341
GLU A 344
 ZN  A1363 (-2.1A)
None
None
None
 1.32A 6mn5D-1h2bA:
2.8		 6mn5D-1h2bA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h2b ALCOHOL
DEHYDROGENASE
(Aeropyrum
pernix) 		4 / 7 THR A 172
TRP A  65
HIS A  59
LEU A 315
 NAJ  A1361 (-3.4A)
None
NAJ  A1361 (-3.9A)
None
 1.06A 6nmfA-1h2bA:
0.0
6nmfC-1h2bA:
0.0
6nmfP-1h2bA:
undetectable		 6nmfA-1h2bA:
21.42
6nmfC-1h2bA:
19.62
6nmfP-1h2bA:
19.62