SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 1h2h HYPOTHETICAL PROTEIN
TM1643
(Thermotoga
maritima) 		5 / 12 VAL A 180
VAL A 178
ILE A 169
ILE A 110
ALA A 109
 None
None
None
None
NAD  A1242 (-3.8A)
 1.23A 2gj5A-1h2hA:
0.0		 2gj5A-1h2hA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1h2h HYPOTHETICAL PROTEIN
TM1643
(Thermotoga
maritima) 		5 / 12 VAL A 180
ILE A 169
THR A 168
LEU A 113
HIS A 193
 None
 1.12A 2jn3A-1h2hA:
undetectable		 2jn3A-1h2hA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1h2h HYPOTHETICAL PROTEIN
TM1643
(Thermotoga
maritima) 		4 / 8 GLY A 174
ILE A 169
VAL A 126
VAL A 123
 None
 0.74A 3fi0I-1h2hA:
undetectable		 3fi0I-1h2hA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1h2h HYPOTHETICAL PROTEIN
TM1643
(Thermotoga
maritima) 		4 / 7 VAL A  49
ILE A  24
TYR A  25
ILE A   5
 None
 1.01A 3hgxA-1h2hA:
undetectable		 3hgxA-1h2hA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1h2h HYPOTHETICAL PROTEIN
TM1643
(Thermotoga
maritima) 		5 / 12 ASN A 210
VAL A  53
ILE A  78
ASN A 164
GLU A  54
 None
None
NAD  A1242 (-4.3A)
NAD  A1242 (-2.6A)
None
 1.29A 3jayA-1h2hA:
0.0		 3jayA-1h2hA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1h2h HYPOTHETICAL PROTEIN
TM1643
(Thermotoga
maritima) 		5 / 12 LEU A 222
GLY A 170
GLY A 111
LEU A 116
ILE A 172
 None
 1.12A 3ku1G-1h2hA:
5.2		 3ku1G-1h2hA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 1h2h HYPOTHETICAL PROTEIN
TM1643
(Thermotoga
maritima) 		5 / 12 PHE A  92
SER A  65
PHE A  43
VAL A  45
ALA A 101
 None
 1.34A 3nhxA-1h2hA:
0.0		 3nhxA-1h2hA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 1h2h HYPOTHETICAL PROTEIN
TM1643
(Thermotoga
maritima) 		3 / 3 LYS A  62
LYS A 157
ALA A  84
 None
 1.42A 4ot2A-1h2hA:
undetectable		 4ot2A-1h2hA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1h2h HYPOTHETICAL PROTEIN
TM1643
(Thermotoga
maritima) 		4 / 4 GLY A 174
VAL A 178
PHE A 206
ILE A 197
 None
 1.08A 4xv2B-1h2hA:
undetectable		 4xv2B-1h2hA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1h2h HYPOTHETICAL PROTEIN
TM1643
(Thermotoga
maritima) 		5 / 10 ILE A   6
ILE A   5
ILE A  76
ILE A  77
ILE A  78
 None
None
None
None
NAD  A1242 (-4.3A)
 1.01A 5murE-1h2hA:
undetectable		 5murE-1h2hA:
15.32