SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h2s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1h2s SENSORY RHODOPSIN II
(Natronomonas
pharaonis) 		3 / 3 ARG A  72
GLY A 181
ASP A 193
 None
 0.59A 1kf6A-1h2sA:
2.4
1kf6B-1h2sA:
0.0		 1kf6A-1h2sA:
19.11
1kf6B-1h2sA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1h2s SENSORY RHODOPSIN II
TRANSDUCER
(Natronomonas
pharaonis) 		4 / 5 ILE B  68
LEU B  65
VAL B  61
ALA B  54
 None
 0.97A 1mz9C-1h2sB:
2.6		 1mz9C-1h2sB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 1h2s SENSORY RHODOPSIN II
SENSORY RHODOPSIN II
TRANSDUCER
(Natronomonas
pharaonis) 		6 / 12 LEU B  35
ALA A 195
ASP A 193
GLY B  66
ALA B  38
ILE B  39
 None
 1.46A 1rl8B-1h2sB:
undetectable		 1rl8B-1h2sB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1h2s SENSORY RHODOPSIN II
SENSORY RHODOPSIN II
TRANSDUCER
(Natronomonas
pharaonis) 		5 / 12 ALA A  12
ILE A  13
VAL A 198
ALA A 195
LEU B  32
 None
 1.07A 1uduB-1h2sA:
undetectable		 1uduB-1h2sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1h2s SENSORY RHODOPSIN II
SENSORY RHODOPSIN II
TRANSDUCER
(Natronomonas
pharaonis;
Natronomonas
pharaonis) 		5 / 12 ILE B  69
LEU A 188
ILE A 173
PRO A 190
VAL A 203
 None
 0.95A 2ygqA-1h2sB:
undetectable		 2ygqA-1h2sB:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1h2s SENSORY RHODOPSIN II
SENSORY RHODOPSIN II
TRANSDUCER
(Natronomonas
pharaonis) 		4 / 6 LEU A 196
ILE B  39
ALA B  40
THR A 189
 None
 1.05A 3mdrA-1h2sA:
1.4		 3mdrA-1h2sA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1h2s SENSORY RHODOPSIN II
(Natronomonas
pharaonis) 		4 / 5 TYR A 139
ILE A 156
LEU A 159
LYS A 157
 None
 1.27A 3sueC-1h2sA:
undetectable		 3sueC-1h2sA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1h2s SENSORY RHODOPSIN II
(Natronomonas
pharaonis) 		4 / 5 TYR A 140
ILE A 156
LEU A 159
LYS A 157
 None
 1.21A 3sueC-1h2sA:
undetectable		 3sueC-1h2sA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1h2s SENSORY RHODOPSIN II
(Natronomonas
pharaonis) 		5 / 8 GLY A  45
GLY A  42
SER A  44
GLY A  18
VAL A 206
 None
 1.35A 3v1nA-1h2sA:
undetectable		 3v1nA-1h2sA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1h2s SENSORY RHODOPSIN II
(Natronomonas
pharaonis) 		5 / 12 ALA A  47
GLY A  42
GLY A  45
GLY A  18
LEU A  82
 None
 1.16A 5c0oE-1h2sA:
undetectable		 5c0oE-1h2sA:
21.86