SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXD_A_ACRA732_1 (ALPHA AMYLASE)	1h2u	20 KDA NUCLEAR CAP BINDING PROTEIN (Homo sapiens)	5 / 9	GLY X 147 GLY X 150 GLY X 132 GLY X 131 ASP X 74	None	1.11A	1mxdA-1h2uX: undetectable	1mxdA-1h2uX: 17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXG_A_ACRA442_1 (ALPHA AMYLASE)	1h2u	20 KDA NUCLEAR CAP BINDING PROTEIN (Homo sapiens)	5 / 11	GLY X 147 GLY X 150 GLY X 132 GLY X 131 ASP X 74	None	1.11A	1mxgA-1h2uX: undetectable	1mxgA-1h2uX: 17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_ACTA502_0 (CHORISMATE SYNTHASE)	1h2u	20 KDA NUCLEAR CAP BINDING PROTEIN (Homo sapiens)	3 / 3	GLY X 118 ASP X 116 SER X 39	None 7MG X1154 (-4.0A) None	0.46A	2qhfA-1h2uX: undetectable	2qhfA-1h2uX: 17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P4W_C_DSFC320_1 (GLR4197 PROTEIN)	1h2u	20 KDA NUCLEAR CAP BINDING PROTEIN (Homo sapiens)	4 / 8	TYR X 57 ILE X 56 VAL X 86 ILE X 101	None	0.88A	3p4wC-1h2uX: undetectable	3p4wC-1h2uX: 17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MZR_E_PFLE409_1 (PROTON-GATED ION CHANNEL)	1h2u	20 KDA NUCLEAR CAP BINDING PROTEIN (Homo sapiens)	4 / 8	TYR X 57 ILE X 56 VAL X 86 ILE X 101	None	0.90A	5mzrE-1h2uX: undetectable	5mzrE-1h2uX: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOO_B_C2FB702_1 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	1h2u	20 KDA NUCLEAR CAP BINDING PROTEIN (Homo sapiens)	4 / 5	ASP X 141 ASP X 136 ASN X 46 ARG X 105	None	1.35A	5vooB-1h2uX: undetectable	5vooB-1h2uX: 18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOO_D_C2FD3001_1 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	1h2u	20 KDA NUCLEAR CAP BINDING PROTEIN (Homo sapiens)	4 / 5	ASP X 141 ASP X 136 ASN X 46 ARG X 105	None	1.38A	5vooD-1h2uX: undetectable	5vooD-1h2uX: 18.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MXD_A_ACRA732_1","ALPHA AMYLASE","1h2u","20 KDA NUCLEAR CAP BINDING PROTEIN","Homo sapiens",5,"GLY X 147;GLY X 150;GLY X 132;GLY X 131;ASP X  74","None","1.11A","1mxdA-1h2uX:undetectable","1mxdA-1h2uX:17.32"],["1MXG_A_ACRA442_1","ALPHA AMYLASE","1h2u","20 KDA NUCLEAR CAP BINDING PROTEIN","Homo sapiens",5,"GLY X 147;GLY X 150;GLY X 132;GLY X 131;ASP X  74","None","1.11A","1mxgA-1h2uX:undetectable","1mxgA-1h2uX:17.32"],["2QHF_A_ACTA502_0","CHORISMATE SYNTHASE","1h2u","20 KDA NUCLEAR CAP BINDING PROTEIN","Homo sapiens",3,"GLY X 118;ASP X 116;SER X  39","None;7MG X1154 (-4.0A);None","0.46A","2qhfA-1h2uX:undetectable","2qhfA-1h2uX:17.90"],["3P4W_C_DSFC320_1","GLR4197 PROTEIN","1h2u","20 KDA NUCLEAR CAP BINDING PROTEIN","Homo sapiens",4,"TYR X  57;ILE X  56;VAL X  86;ILE X 101","None","0.88A","3p4wC-1h2uX:undetectable","3p4wC-1h2uX:17.25"],["5MZR_E_PFLE409_1","PROTON-GATED ION CHANNEL","1h2u","20 KDA NUCLEAR CAP BINDING PROTEIN","Homo sapiens",4,"TYR X  57;ILE X  56;VAL X  86;ILE X 101","None","0.90A","5mzrE-1h2uX:undetectable","5mzrE-1h2uX:18.18"],["5VOO_B_C2FB702_1","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","1h2u","20 KDA NUCLEAR CAP BINDING PROTEIN","Homo sapiens",4,"ASP X 141;ASP X 136;ASN X  46;ARG X 105","None","1.35A","5vooB-1h2uX:undetectable","5vooB-1h2uX:18.03"],["5VOO_D_C2FD3001_1","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","1h2u","20 KDA NUCLEAR CAP BINDING PROTEIN","Homo sapiens",4,"ASP X 141;ASP X 136;ASN X  46;ARG X 105","None","1.38A","5vooD-1h2uX:undetectable","5vooD-1h2uX:18.03"]]