SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h3d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE
(Escherichia
coli) 		5 / 12 THR A 129
ILE A 196
LEU A 106
ARG A 137
LEU A  82
 None
 1.22A 1eiiA-1h3dA:
0.0		 1eiiA-1h3dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE
(Escherichia
coli) 		4 / 4 THR A 235
LEU A 238
VAL A 241
LEU A 245
 None
 0.97A 1fbmD-1h3dA:
undetectable		 1fbmD-1h3dA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE
(Escherichia
coli) 		4 / 8 VAL A  66
ARG A   8
VAL A  53
ILE A  40
 None
 0.83A 1igxA-1h3dA:
undetectable		 1igxA-1h3dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE
(Escherichia
coli) 		4 / 6 LEU A 151
SER A 130
ASP A 169
GLU A 156
 None
None
AMP  A 400 (-2.8A)
AMP  A 400 (-3.1A)
 1.14A 2j2pE-1h3dA:
0.0
2j2pF-1h3dA:
0.0		 2j2pE-1h3dA:
22.55
2j2pF-1h3dA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE
(Escherichia
coli) 		3 / 3 VAL A  76
GLU A  80
GLU A  79
 None
 0.78A 2nv4A-1h3dA:
undetectable		 2nv4A-1h3dA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE
(Escherichia
coli) 		4 / 6 MET A 265
PRO A 251
ILE A 229
LEU A 281
 None
 1.26A 2wekB-1h3dA:
undetectable		 2wekB-1h3dA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		 1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE
(Escherichia
coli) 		5 / 12 MET A 267
MET A 265
ALA A 264
SER A 288
ILE A 289
 None
 1.20A 4qe6A-1h3dA:
0.0		 4qe6A-1h3dA:
22.48