SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 ALA A 249
ILE A 309
ARG A 256
LEU A 269
LEU A 227
 None
None
A  B  36 ( 3.7A)
None
None
 0.94A 1eiiA-1h3eA:
0.0		 1eiiA-1h3eA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		6 / 11 GLY A  43
HIS A  52
HIS A  55
GLY A 194
ASP A 196
GLN A 197
 TYE  A1434 ( 3.5A)
ATP  A1433 (-4.3A)
ATP  A1433 (-4.2A)
ATP  A1433 (-3.2A)
ATP  A1433 ( 4.2A)
TYE  A1434 ( 3.5A)
 0.71A 1jzsA-1h3eA:
1.1		 1jzsA-1h3eA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 HIS A  52
GLY A  54
HIS A  55
GLY A 194
ASP A 196
 ATP  A1433 (-4.3A)
ATP  A1433 (-3.4A)
ATP  A1433 (-4.2A)
ATP  A1433 (-3.2A)
ATP  A1433 ( 4.2A)
 0.43A 1pg2A-1h3eA:
10.1		 1pg2A-1h3eA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A  54
HIS A  55
GLY A 194
ASP A 196
GLN A 197
 ATP  A1433 (-3.4A)
ATP  A1433 (-4.2A)
ATP  A1433 (-3.2A)
ATP  A1433 ( 4.2A)
TYE  A1434 ( 3.5A)
 0.70A 1qu2A-1h3eA:
5.0		 1qu2A-1h3eA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.35A 1v8bA-1h3eA:
undetectable		 1v8bA-1h3eA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.38A 1v8bB-1h3eA:
undetectable		 1v8bB-1h3eA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.36A 1v8bC-1h3eA:
undetectable		 1v8bC-1h3eA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.39A 1v8bD-1h3eA:
3.5		 1v8bD-1h3eA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 TYR A 265
LEU A 269
HIS A 289
ALA A 249
VAL A 257
 None
None
G  B  34 ( 4.4A)
None
None
 1.42A 2g70B-1h3eA:
undetectable		 2g70B-1h3eA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 TYR A 265
LEU A 269
HIS A 289
ALA A 249
VAL A 257
 None
None
G  B  34 ( 4.4A)
None
None
 1.39A 2g72A-1h3eA:
2.0		 2g72A-1h3eA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 MET A 250
LEU A 254
GLY A  54
MET A 233
 None
None
ATP  A1433 (-3.4A)
None
 0.93A 2qd5B-1h3eA:
2.2		 2qd5B-1h3eA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 ALA A  44
HIS A  52
GLY A  54
HIS A  55
GLY A 193
 ATP  A1433 (-3.8A)
ATP  A1433 (-4.3A)
ATP  A1433 (-3.4A)
ATP  A1433 (-4.2A)
ATP  A1433 (-3.1A)
 1.11A 2x1lA-1h3eA:
9.7		 2x1lA-1h3eA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		6 / 11 ALA A  44
HIS A  52
GLY A  54
HIS A  55
GLY A 194
ASP A 196
 ATP  A1433 (-3.8A)
ATP  A1433 (-4.3A)
ATP  A1433 (-3.4A)
ATP  A1433 (-4.2A)
ATP  A1433 (-3.2A)
ATP  A1433 ( 4.2A)
 0.73A 2x1lA-1h3eA:
9.7		 2x1lA-1h3eA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		7 / 12 ALA A  44
HIS A  52
GLY A  54
HIS A  55
GLY A 194
ASP A 196
LEU A 224
 ATP  A1433 (-3.8A)
ATP  A1433 (-4.3A)
ATP  A1433 (-3.4A)
ATP  A1433 (-4.2A)
ATP  A1433 (-3.2A)
ATP  A1433 ( 4.2A)
ATP  A1433 (-4.5A)
 0.77A 2x1lB-1h3eA:
9.6		 2x1lB-1h3eA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		6 / 11 ALA A  44
HIS A  52
GLY A  54
HIS A  55
GLY A 194
ASP A 196
 ATP  A1433 (-3.8A)
ATP  A1433 (-4.3A)
ATP  A1433 (-3.4A)
ATP  A1433 (-4.2A)
ATP  A1433 (-3.2A)
ATP  A1433 ( 4.2A)
 0.70A 2x1lC-1h3eA:
9.6		 2x1lC-1h3eA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 VAL A 257
LEU A 243
GLY A  54
ALA A  56
 None
None
ATP  A1433 (-3.4A)
None
 0.80A 2xfsA-1h3eA:
0.3		 2xfsA-1h3eA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 VAL A 257
LEU A 243
GLY A  54
ALA A  56
 None
None
ATP  A1433 (-3.4A)
None
 0.81A 2xh9A-1h3eA:
0.3		 2xh9A-1h3eA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.43A 2zj0A-1h3eA:
undetectable		 2zj0A-1h3eA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 SER A  87
GLN A 197
VAL A  23
CYH A 218
 None
TYE  A1434 ( 3.5A)
None
None
 1.20A 3b9lA-1h3eA:
0.0		 3b9lA-1h3eA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.42A 3ce6A-1h3eA:
3.6		 3ce6A-1h3eA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.43A 3ce6C-1h3eA:
undetectable		 3ce6C-1h3eA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 TYR A 108
GLY A 242
THR A 107
GLU A 245
 None
 0.89A 3fpjA-1h3eA:
2.7		 3fpjA-1h3eA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.41A 3g1uA-1h3eA:
undetectable		 3g1uA-1h3eA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.38A 3glqA-1h3eA:
undetectable		 3glqA-1h3eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.40A 3glqB-1h3eA:
undetectable		 3glqB-1h3eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.44A 3h9uA-1h3eA:
undetectable		 3h9uA-1h3eA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.44A 3h9uC-1h3eA:
3.4		 3h9uC-1h3eA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.43A 3h9uD-1h3eA:
undetectable		 3h9uD-1h3eA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 LEU A 377
GLU A 363
PRO A 360
ARG A 373
 None
None
None
G  B  47 ( 3.6A)
 1.45A 3ltwA-1h3eA:
undetectable		 3ltwA-1h3eA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 LYS A 422
ARG A 256
LYS A 328
 U  B  33 ( 4.4A)
A  B  36 ( 3.7A)
None
 1.12A 3okxA-1h3eA:
undetectable		 3okxA-1h3eA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 ASN A 128
TRP A 131
ASP A  45
 TYE  A1434 ( 4.8A)
None
TYE  A1434 ( 3.8A)
 0.80A 4a7tA-1h3eA:
0.1
4a7tF-1h3eA:
0.2		 4a7tA-1h3eA:
16.03
4a7tF-1h3eA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 ALA A 112
TYR A 108
ALA A  44
ILE A  75
ILE A  76
 None
None
ATP  A1433 (-3.8A)
TYE  A1434 ( 3.9A)
None
 1.15A 4eatB-1h3eA:
undetectable		 4eatB-1h3eA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.38A 4lvcA-1h3eA:
undetectable		 4lvcA-1h3eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.38A 4lvcC-1h3eA:
undetectable		 4lvcC-1h3eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 GLY A 395
THR A 381
LEU A 418
PHE A 375
 G  B  29 ( 3.2A)
None
None
None
 1.19A 4m5mA-1h3eA:
undetectable		 4m5mA-1h3eA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.42A 4pfjA-1h3eA:
3.7		 4pfjA-1h3eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 SER A 129
ASP A  78
ILE A  75
GLN A 216
ILE A 186
 None
None
TYE  A1434 ( 3.9A)
None
None
 1.30A 4uroA-1h3eA:
undetectable		 4uroA-1h3eA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 LYS A 114
ILE A 305
ILE A 309
 None
 0.53A 4y0qA-1h3eA:
0.0		 4y0qA-1h3eA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.40A 5axaA-1h3eA:
3.7		 5axaA-1h3eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.41A 5axaC-1h3eA:
undetectable		 5axaC-1h3eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 HIS A  52
GLY A  54
HIS A  55
GLY A 194
ASP A 196
 ATP  A1433 (-4.3A)
ATP  A1433 (-3.4A)
ATP  A1433 (-4.2A)
ATP  A1433 (-3.2A)
ATP  A1433 ( 4.2A)
 0.96A 5hg0B-1h3eA:
10.1		 5hg0B-1h3eA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.39A 5hm8A-1h3eA:
undetectable		 5hm8A-1h3eA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.39A 5hm8B-1h3eA:
undetectable		 5hm8B-1h3eA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.39A 5hm8C-1h3eA:
undetectable		 5hm8C-1h3eA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.38A 5hm8D-1h3eA:
undetectable		 5hm8D-1h3eA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.39A 5hm8E-1h3eA:
undetectable		 5hm8E-1h3eA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.38A 5hm8F-1h3eA:
undetectable		 5hm8F-1h3eA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.38A 5hm8G-1h3eA:
undetectable		 5hm8G-1h3eA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.39A 5hm8H-1h3eA:
undetectable		 5hm8H-1h3eA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 ARG A 155
GLY A  88
ASP A 157
ASP A  85
 None
None
None
TYE  A1434 (-3.8A)
 1.32A 5hp1A-1h3eA:
0.4		 5hp1A-1h3eA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 ALA A 299
ILE A 115
ARG A  63
GLY A 242
LEU A 254
 None
 1.12A 5m24A-1h3eA:
undetectable		 5m24A-1h3eA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.38A 5m5kA-1h3eA:
undetectable		 5m5kA-1h3eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.41A 5m5kC-1h3eA:
undetectable		 5m5kC-1h3eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.38A 5m66A-1h3eA:
2.2		 5m66A-1h3eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.37A 5m66B-1h3eA:
undetectable		 5m66B-1h3eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.37A 5utuF-1h3eA:
undetectable		 5utuF-1h3eA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.37A 5utuH-1h3eA:
undetectable		 5utuH-1h3eA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 LEU A 296
ALA A 293
LEU A  53
 None
 0.54A 5uunB-1h3eA:
undetectable		 5uunB-1h3eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.39A 5v96A-1h3eA:
3.6		 5v96A-1h3eA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.40A 5v96B-1h3eA:
undetectable		 5v96B-1h3eA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.40A 5v96C-1h3eA:
3.7		 5v96C-1h3eA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.39A 5v96D-1h3eA:
3.7		 5v96D-1h3eA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_1
(-)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.43A 6gbnA-1h3eA:
undetectable		 6gbnA-1h3eA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_1
(-)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.43A 6gbnD-1h3eA:
undetectable		 6gbnD-1h3eA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 ASP A 189
THR A  39
HIS A  70
GLY A  35
GLU A  34
 None
 1.19A 6mb9A-1h3eA:
0.0		 6mb9A-1h3eA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 ASP A 189
THR A  39
HIS A  70
GLY A  35
GLU A  34
 None
 1.19A 6mb9D-1h3eA:
undetectable		 6mb9D-1h3eA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1h3e TYROSYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 ILE A  76
ALA A  44
GLY A  43
GLY A  84
TYR A 175
 None
ATP  A1433 (-3.8A)
TYE  A1434 ( 3.5A)
None
TYE  A1434 (-4.3A)
 1.28A 6nm4B-1h3eA:
undetectable		 6nm4B-1h3eA:
18.50