SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h3m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJF_A_ADNA2001_1 (235AA LONG HYPOTHETICAL BIOTIN--[ACETYL-COA- CARBOXYLASE] LIGASE)	1h3m	2-C-METHYL-D-ERYTHRI TOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE (Escherichia coli)	4 / 7	ARG A 64 GLU A 39 ALA A 14 ALA A 107	None	1.07A	2ejfA-1h3mA: 0.0	2ejfA-1h3mA: 20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3M6W_A_SAMA465_0 (RRNA METHYLASE)	1h3m	2-C-METHYL-D-ERYTHRI TOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE (Escherichia coli)	5 / 12	ALA A 57 GLY A 61 ASP A 87 PRO A 13 VAL A 104	None	1.05A	3m6wA-1h3mA: undetectable	3m6wA-1h3mA: 20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O14_A_NIOA300_1 (ANTI-ECFSIGMA FACTOR, CHRR)	1h3m	2-C-METHYL-D-ERYTHRI TOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE (Escherichia coli)	4 / 7	ALA A 107 VAL A 54 VAL A 42 LEU A 38	None	0.84A	3o14A-1h3mA: undetectable	3o14A-1h3mA: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUF_D_SUED1201_1 (NS3 PROTEASE, NS4A PROTEIN)	1h3m	2-C-METHYL-D-ERYTHRI TOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE (Escherichia coli)	5 / 12	ILE A 56 GLY A 92 SER A 88 ALA A 15 ALA A 14	None	1.01A	3sufD-1h3mA: undetectable	3sufD-1h3mA: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GC9_A_ACTA402_0 (DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL)	1h3m	2-C-METHYL-D-ERYTHRI TOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE (Escherichia coli)	3 / 3	LYS A 25 TYR A 29 ARG A 64	None	1.23A	4gc9A-1h3mA: 2.9	4gc9A-1h3mA: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MDA_A_RLTA403_1 (MARINER MOS1 TRANSPOSASE)	1h3m	2-C-METHYL-D-ERYTHRI TOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE (Escherichia coli)	4 / 6	ASP A 115 ASP A 116 ASN A 211 ALA A 134	None	1.16A	4mdaA-1h3mA: 0.0	4mdaA-1h3mA: 23.58

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2EJF_A_ADNA2001_1","235AA LONG HYPOTHETICAL BIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE","1h3m","2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE","Escherichia coli",4,"ARG A  64;GLU A  39;ALA A  14;ALA A 107","None","1.07A","2ejfA-1h3mA:0.0","2ejfA-1h3mA:20.77"],["3M6W_A_SAMA465_0","RRNA METHYLASE","1h3m","2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE","Escherichia coli",5,"ALA A  57;GLY A  61;ASP A  87;PRO A  13;VAL A 104","None","1.05A","3m6wA-1h3mA:undetectable","3m6wA-1h3mA:20.69"],["3O14_A_NIOA300_1","ANTI-ECFSIGMA FACTOR, CHRR","1h3m","2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE","Escherichia coli",4,"ALA A 107;VAL A  54;VAL A  42;LEU A  38","None","0.84A","3o14A-1h3mA:undetectable","3o14A-1h3mA:22.39"],["3SUF_D_SUED1201_1","NS3 PROTEASE, NS4A PROTEIN","1h3m","2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE","Escherichia coli",5,"ILE A  56;GLY A  92;SER A  88;ALA A  15;ALA A  14","None","1.01A","3sufD-1h3mA:undetectable","3sufD-1h3mA:20.87"],["4GC9_A_ACTA402_0","DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL","1h3m","2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE","Escherichia coli",3,"LYS A  25;TYR A  29;ARG A  64","None","1.23A","4gc9A-1h3mA:2.9","4gc9A-1h3mA:20.29"],["4MDA_A_RLTA403_1","MARINER MOS1 TRANSPOSASE","1h3m","2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE","Escherichia coli",4,"ASP A 115;ASP A 116;ASN A 211;ALA A 134","None","1.16A","4mdaA-1h3mA:0.0","4mdaA-1h3mA:23.58"]]