SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h3q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1h3q SEDLIN
(Mus
musculus) 		4 / 8 GLY A  11
THR A  77
HIS A  80
ILE A   9
 None
 0.80A 1gtnA-1h3qA:
undetectable
1gtnB-1h3qA:
undetectable		 1gtnA-1h3qA:
19.12
1gtnB-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1h3q SEDLIN
(Mus
musculus) 		5 / 10 GLY A  11
HIS A  12
THR A  77
HIS A  80
ILE A   9
 None
 1.01A 1gtnU-1h3qA:
0.1
1gtnV-1h3qA:
0.2		 1gtnU-1h3qA:
19.12
1gtnV-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1h3q SEDLIN
(Mus
musculus) 		5 / 12 GLY A  11
HIS A  12
THR A  77
HIS A  80
ILE A   9
 None
 0.99A 1gtnL-1h3qA:
0.1
1gtnV-1h3qA:
0.2		 1gtnL-1h3qA:
19.12
1gtnV-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1h3q SEDLIN
(Mus
musculus) 		4 / 8 GLY A  11
THR A  77
HIS A  80
ILE A   9
 None
 0.79A 1utdB-1h3qA:
undetectable
1utdC-1h3qA:
undetectable		 1utdB-1h3qA:
19.12
1utdC-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1h3q SEDLIN
(Mus
musculus) 		4 / 8 GLY A  11
THR A  77
HIS A  80
ILE A   9
 None
 0.77A 1utdI-1h3qA:
undetectable
1utdJ-1h3qA:
undetectable		 1utdI-1h3qA:
19.12
1utdJ-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1h3q SEDLIN
(Mus
musculus) 		4 / 8 GLY A  11
THR A  77
HIS A  80
ILE A   9
 None
 0.78A 1utdJ-1h3qA:
undetectable
1utdK-1h3qA:
0.8		 1utdJ-1h3qA:
19.12
1utdK-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1h3q SEDLIN
(Mus
musculus) 		5 / 10 GLY A  11
HIS A  12
THR A  77
HIS A  80
ILE A   9
 None
 0.98A 1utdQ-1h3qA:
0.1
1utdR-1h3qA:
0.1		 1utdQ-1h3qA:
19.12
1utdR-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1h3q SEDLIN
(Mus
musculus) 		5 / 11 GLY A  11
HIS A  12
THR A  77
HIS A  80
ILE A   9
 None
 1.01A 1utdL-1h3qA:
undetectable
1utdV-1h3qA:
undetectable		 1utdL-1h3qA:
19.12
1utdV-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 1h3q SEDLIN
(Mus
musculus) 		4 / 7 PHE A  99
TYR A 106
TYR A 103
THR A  77
 None
 1.41A 2q6kA-1h3qA:
0.1		 2q6kA-1h3qA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1h3q SEDLIN
(Mus
musculus) 		5 / 12 PHE A  75
ASN A 118
ASP A 104
ILE A 107
ASN A  58
 None
 1.05A 3ps9A-1h3qA:
undetectable		 3ps9A-1h3qA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1h3q SEDLIN
(Mus
musculus) 		3 / 3 LEU A 139
VAL A  89
ASP A  88
 None
 0.54A 4y8wC-1h3qA:
undetectable		 4y8wC-1h3qA:
14.45