SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		4 / 8 ALA A  48
GLU A  51
LEU A  78
LEU A  37
 None
 0.92A 1ereE-1h4lA:
undetectable		 1ereE-1h4lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		4 / 8 ALA A  48
GLU A  51
LEU A  78
LEU A  37
 None
 0.91A 1ereF-1h4lA:
undetectable		 1ereF-1h4lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 9 LEU A  70
LEU A  66
LYS A  56
ILE A  52
VAL A  35
 None
 1.14A 1gx8A-1h4lA:
undetectable		 1gx8A-1h4lA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 1h4l CELL DIVISION
PROTEIN KINASE 5
CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR
(Homo
sapiens) 		5 / 11 LEU A  49
LEU D 245
LEU D 249
LEU A  76
HIS A  71
 None
 1.16A 1mx1B-1h4lA:
undetectable		 1mx1B-1h4lA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
VAL A  64
PHE A  82
LEU A 133
ALA A 143
 None
 0.47A 1opjA-1h4lA:
16.4		 1opjA-1h4lA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
VAL A  64
PHE A  82
ALA A 143
 None
 0.81A 1opjB-1h4lA:
16.6		 1opjB-1h4lA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 10 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 0.95A 1pxxA-1h4lA:
0.0		 1pxxA-1h4lA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 0.94A 1pxxC-1h4lA:
0.0		 1pxxC-1h4lA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 1h4l CELL DIVISION
PROTEIN KINASE 5
CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR
(Homo
sapiens) 		5 / 12 VAL A  35
ILE D 265
LEU D 262
ALA A  48
LEU A  37
 None
 1.00A 1r9oA-1h4lA:
0.0		 1r9oA-1h4lA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1h4l CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR
(Homo
sapiens) 		4 / 8 THR D 228
CYH D 208
TRP D 177
LEU D 204
 None
 1.48A 1uw6A-1h4lD:
undetectable
1uw6B-1h4lD:
undetectable		 1uw6A-1h4lD:
24.02
1uw6B-1h4lD:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1h4l CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR
(Homo
sapiens) 		4 / 8 THR D 228
CYH D 208
TRP D 177
LEU D 204
 None
 1.45A 1uw6P-1h4lD:
undetectable
1uw6Q-1h4lD:
undetectable		 1uw6P-1h4lD:
24.02
1uw6Q-1h4lD:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 ALA A  31
LYS A  33
GLU A  51
LEU A  55
CYH A  83
HIS A 124
 None
 0.80A 1uwhB-1h4lA:
14.6		 1uwhB-1h4lA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		4 / 7 ILE A  10
LYS A  33
LEU A  55
ILE A  63
 None
 0.84A 1uwjA-1h4lA:
5.5		 1uwjA-1h4lA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 ILE A  10
VAL A  18
ALA A  31
GLU A  51
CYH A  83
HIS A 124
 None
 0.77A 1uwjB-1h4lA:
23.3		 1uwjB-1h4lA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		4 / 8 VAL A  64
LEU A  66
VAL A  69
VAL A  35
 None
 0.97A 2bdmA-1h4lA:
0.1		 2bdmA-1h4lA:
21.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		9 / 12 ILE A  10
VAL A  18
LYS A  33
VAL A  64
PHE A  80
ASP A  86
ASN A 131
LEU A 133
ALA A 143
 None
 0.89A 2eufB-1h4lA:
31.2		 2eufB-1h4lA:
45.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		7 / 12 VAL A  18
ALA A  31
GLU A  51
VAL A  64
PHE A  82
LEU A 133
ALA A 143
 None
 0.76A 2hyyC-1h4lA:
23.8		 2hyyC-1h4lA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
PHE A  82
LEU A 133
ALA A 143
 None
 0.93A 2hyyD-1h4lA:
17.0		 2hyyD-1h4lA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 132
LEU A 133
ILE A  63
GLY A 113
LEU A 114
 None
 1.29A 2j7xA-1h4lA:
0.7		 2j7xA-1h4lA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1h4l CELL DIVISION
PROTEIN KINASE 5
CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS A  43
TYR D 231
PRO A  45
 None
 1.30A 2j9cC-1h4lA:
0.0		 2j9cC-1h4lA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 11 LEU A 267
ARG A 274
ILE A 215
LEU A 173
ASP A 171
 None
 1.19A 2q6hA-1h4lA:
0.0		 2q6hA-1h4lA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 11 LEU A 267
ARG A 274
ILE A 215
LEU A 173
ASP A 171
 None
 1.19A 2q72A-1h4lA:
0.0		 2q72A-1h4lA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 11 LEU A 267
ARG A 274
ILE A 215
LEU A 173
ASP A 171
 None
 1.19A 2qeiA-1h4lA:
0.8		 2qeiA-1h4lA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 11 LEU A 267
ARG A 274
ILE A 215
LEU A 173
ASP A 171
 None
 1.17A 2qjuA-1h4lA:
0.0		 2qjuA-1h4lA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 PHE A  80
LEU A  66
ALA A 148
SER A  47
TYR A  15
 None
 1.44A 3apvA-1h4lA:
0.0		 3apvA-1h4lA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 PHE A  80
LEU A  66
ALA A 148
SER A  47
TYR A  15
 None
 1.43A 3apvB-1h4lA:
0.0		 3apvB-1h4lA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 PHE A  80
LEU A  66
ALA A 148
SER A  47
TYR A  15
 None
 1.44A 3apwB-1h4lA:
0.0		 3apwB-1h4lA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 ALA A  31
LYS A  33
VAL A  64
PHE A  82
CYH A  83
LEU A 133
 None
 0.56A 3c7qA-1h4lA:
18.1		 3c7qA-1h4lA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 ALA A  31
VAL A  64
HIS A 124
LEU A 133
ALA A 143
 None
 0.44A 3ik3A-1h4lA:
16.0		 3ik3A-1h4lA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 ALA A  31
VAL A  64
HIS A 124
LEU A 133
ALA A 143
 None
 0.47A 3ik3B-1h4lA:
22.9		 3ik3B-1h4lA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 11 ALA A  31
LYS A  33
VAL A  64
PHE A  80
LEU A 133
ASP A 144
 None
 0.74A 3miyA-1h4lA:
20.5		 3miyA-1h4lA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		7 / 11 ILE A  10
ALA A  31
LYS A  33
VAL A  64
PHE A  80
PHE A  82
LEU A 133
 None
 0.66A 3miyA-1h4lA:
20.5		 3miyA-1h4lA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 9 ILE A  10
ALA A  31
LYS A  33
PHE A  80
PHE A  82
LEU A 133
 None
 0.67A 3miyB-1h4lA:
24.9		 3miyB-1h4lA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
PHE A  82
LEU A 133
ALA A 143
 None
 0.88A 3ms9A-1h4lA:
17.1		 3ms9A-1h4lA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
PHE A  82
LEU A 133
ALA A 143
 None
 0.91A 3mssA-1h4lA:
17.1		 3mssA-1h4lA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 ILE A  10
VAL A  18
ALA A  31
LYS A  33
CYH A  83
GLY A 146
 None
 1.14A 3og7A-1h4lA:
17.7		 3og7A-1h4lA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 ILE A  10
VAL A  18
ALA A  31
LYS A  33
LEU A  55
CYH A  83
 None
 0.88A 3og7A-1h4lA:
17.7		 3og7A-1h4lA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 ILE A  10
VAL A  18
LYS A  33
LEU A  55
CYH A  83
PHE A 145
 None
 1.07A 3og7A-1h4lA:
17.7		 3og7A-1h4lA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		4 / 6 VAL A  35
TYR A  15
GLU A  51
ILE A  52
 None
 1.12A 3q5sA-1h4lA:
0.0		 3q5sA-1h4lA:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		8 / 9 ILE A  10
ALA A  31
VAL A  64
PHE A  80
PHE A  82
ASP A  86
LYS A  88
LEU A 133
 None
 0.87A 3ti1A-1h4lA:
31.6		 3ti1A-1h4lA:
60.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 1h4l CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR
(Homo
sapiens) 		4 / 6 SER D 233
VAL D 181
THR D 197
THR D 148
 None
 1.16A 3tneA-1h4lD:
undetectable		 3tneA-1h4lD:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1h4l CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR
(Homo
sapiens) 		4 / 4 PRO D 174
LEU D 222
ILE D 212
ARG D 162
 None
 1.40A 3w1wA-1h4lD:
undetectable		 3w1wA-1h4lD:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 11 ALA A  31
LYS A  33
VAL A  64
PHE A  82
CYH A  83
LEU A 133
 None
 0.57A 4agdA-1h4lA:
16.9		 4agdA-1h4lA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 1h4l CELL DIVISION
PROTEIN KINASE 5
CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR
(Homo
sapiens;
Homo
sapiens) 		4 / 4 TRP D 258
LEU A  49
LEU D 232
THR D 228
 None
 1.16A 4bboD-1h4lD:
undetectable		 4bboD-1h4lD:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		7 / 12 ALA A  31
LYS A  33
GLU A  51
LEU A  55
HIS A 124
LEU A 133
ALA A 143
 None
 0.81A 4c8bA-1h4lA:
22.3		 4c8bA-1h4lA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		7 / 12 ALA A  31
LYS A  33
GLU A  51
LEU A  55
ILE A  63
LEU A 133
ALA A 143
 None
 0.89A 4c8bB-1h4lA:
22.4		 4c8bB-1h4lA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		7 / 12 ALA A  31
LYS A  33
LEU A  55
ILE A  63
HIS A 124
LEU A 133
ALA A 143
 None
 0.71A 4c8bB-1h4lA:
22.4		 4c8bB-1h4lA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 1.03A 4coxA-1h4lA:
0.8		 4coxA-1h4lA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 1.04A 4coxB-1h4lA:
undetectable		 4coxB-1h4lA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 1.04A 4coxD-1h4lA:
undetectable		 4coxD-1h4lA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		7 / 12 VAL A  18
ALA A  31
ASP A  86
ASP A 126
LYS A 128
ASN A 131
LEU A 133
 None
 0.72A 4i41A-1h4lA:
19.3		 4i41A-1h4lA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1h4l CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR
(Homo
sapiens) 		4 / 8 LEU D 152
LEU D 155
LEU D 159
ILE D 196
 None
 0.75A 4klaA-1h4lD:
undetectable		 4klaA-1h4lD:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 8 VAL A  18
ALA A  31
LYS A  33
ASP A  86
LEU A 133
 None
 0.91A 4l9iB-1h4lA:
19.5		 4l9iB-1h4lA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 8 ILE A  10
VAL A  18
ALA A  31
ASP A  86
ASN A 131
LEU A 133
 None
 0.65A 4ogrA-1h4lA:
27.8		 4ogrA-1h4lA:
41.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 7 ALA A  31
CYH A  83
ASP A  86
ASN A 131
LEU A 133
 None
 0.51A 4ogrE-1h4lA:
30.0		 4ogrE-1h4lA:
41.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		7 / 9 ILE A  10
VAL A  18
ALA A  31
CYH A  83
ASP A  86
ASN A 131
LEU A 133
 None
 0.61A 4ogrI-1h4lA:
30.8		 4ogrI-1h4lA:
41.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 1.03A 4otyA-1h4lA:
undetectable		 4otyA-1h4lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 1.04A 4otyB-1h4lA:
undetectable		 4otyB-1h4lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
LYS A  33
GLU A  51
CYH A  83
LEU A 133
 None
 0.81A 4r7iA-1h4lA:
17.5		 4r7iA-1h4lA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 1.02A 4rrwC-1h4lA:
0.0		 4rrwC-1h4lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 1.03A 4rrwD-1h4lA:
undetectable		 4rrwD-1h4lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 1.02A 4rrzC-1h4lA:
0.0		 4rrzC-1h4lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 1.03A 4rrzD-1h4lA:
undetectable		 4rrzD-1h4lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  51
CYH A 117
HIS A 124
ALA A 143
 None
 1.26A 4v04A-1h4lA:
17.9		 4v04A-1h4lA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1h4l CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR
(Homo
sapiens) 		4 / 7 PHE D 248
LEU D 227
SER D 233
VAL D 181
 None
 1.05A 4wnvD-1h4lD:
2.1		 4wnvD-1h4lD:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		7 / 12 VAL A  18
ALA A  31
LYS A  33
VAL A  64
PHE A  82
LEU A 133
ALA A 143
 None
 0.81A 4xeyA-1h4lA:
10.6		 4xeyA-1h4lA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 ALA A  31
LYS A  33
LEU A  55
CYH A  83
PHE A 145
 None
 0.90A 4xv2B-1h4lA:
18.1		 4xv2B-1h4lA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 10 ALA A  31
PHE A  82
CYH A  83
LEU A 133
ALA A 143
 None
 0.60A 5ajqB-1h4lA:
20.2		 5ajqB-1h4lA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		4 / 5 ARG A  50
ARG A 125
LEU A 147
VAL A 162
 None
 0.59A 5cshB-1h4lA:
30.9		 5cshB-1h4lA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
LYS A  33
LEU A  55
CYH A  83
PHE A 145
 None
 1.04A 5cswA-1h4lA:
10.4		 5cswA-1h4lA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 VAL A  18
ALA A  31
LYS A  33
CYH A  83
PHE A 145
 None
 0.76A 5cswB-1h4lA:
23.1		 5cswB-1h4lA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 ALA A  31
LYS A  33
GLU A  51
LEU A  55
CYH A  83
HIS A 124
 None
 0.87A 5hi2A-1h4lA:
15.0		 5hi2A-1h4lA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		4 / 6 PRO A 169
HIS A 124
GLU A  51
ALA A 150
 None
 1.06A 5igiA-1h4lA:
8.1		 5igiA-1h4lA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 0.94A 5ikqA-1h4lA:
undetectable		 5ikqA-1h4lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
 None
 0.93A 5ikqB-1h4lA:
undetectable		 5ikqB-1h4lA:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		7 / 12 VAL A  18
ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 133
ALA A 143
 None
 0.77A 5l2iA-1h4lA:
14.2		 5l2iA-1h4lA:
45.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 133
ALA A 143
 None
 0.70A 5l2tA-1h4lA:
14.5		 5l2tA-1h4lA:
45.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 ILE A  10
ALA A  31
VAL A  64
PHE A  80
ASP A  86
LEU A 133
 None
 0.90A 5l2tA-1h4lA:
14.5		 5l2tA-1h4lA:
45.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 ILE A  10
VAL A  18
ALA A  31
VAL A  64
PHE A  80
LEU A 133
 None
 0.79A 5l2tA-1h4lA:
14.5		 5l2tA-1h4lA:
45.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
VAL A  64
PHE A  80
LEU A 133
ALA A 143
 None
 0.67A 5l2tA-1h4lA:
14.5		 5l2tA-1h4lA:
45.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		4 / 5 LEU A  55
CYH A  83
LEU A 133
ASP A 144
 None
 0.82A 5mafA-1h4lA:
26.7		 5mafA-1h4lA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		5 / 12 ALA A  31
VAL A  64
HIS A 124
LEU A 133
ALA A 143
 None
 0.50A 5mo4A-1h4lA:
16.4		 5mo4A-1h4lA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		6 / 12 GLU A   8
ALA A  31
GLU A  51
VAL A  64
PHE A  82
LEU A 133
 None
 0.86A 5te0A-1h4lA:
25.3		 5te0A-1h4lA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		3 / 3 LEU A 195
ASN A  62
LEU A 127
 None
 0.66A 6exiA-1h4lA:
undetectable		 6exiA-1h4lA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens) 		7 / 12 VAL A  18
ALA A  31
GLU A  51
VAL A  64
PHE A  82
LEU A 133
ALA A 143
 None
 0.81A 6hd6A-1h4lA:
16.5		 6hd6A-1h4lA:
13.33