SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		4 / 8 GLY A  46
THR A 147
GLY A  41
LEU A 116
 BEZ  A1162 (-3.1A)
BEZ  A1162 ( 4.0A)
None
None
 0.85A 1aegA-1h4oA:
undetectable		 1aegA-1h4oA:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		5 / 10 GLY A  46
CYH A  47
LEU A 112
ARG A 127
THR A 147
 BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 1.41A 1h4oA-1h4oA:
36.8
1h4oB-1h4oA:
35.0		 1h4oA-1h4oA:
100.00
1h4oB-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		9 / 10 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
LEU A 116
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.01A 1h4oA-1h4oA:
36.8
1h4oB-1h4oA:
35.0		 1h4oA-1h4oA:
100.00
1h4oB-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		8 / 8 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.25A 1h4oB-1h4oA:
35.0		 1h4oB-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		8 / 9 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.26A 1h4oC-1h4oA:
35.6
1h4oD-1h4oA:
35.6		 1h4oC-1h4oA:
100.00
1h4oD-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H4O_D_BEZD1162_0
(PEROXIREDOXIN 5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		9 / 9 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
LEU A 116
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.22A 1h4oD-1h4oA:
35.6		 1h4oD-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		8 / 9 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.23A 1h4oE-1h4oA:
35.6
1h4oF-1h4oA:
35.7		 1h4oE-1h4oA:
100.00
1h4oF-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H4O_F_BEZF1162_0
(PEROXIREDOXIN 5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		9 / 9 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
LEU A 116
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.22A 1h4oF-1h4oA:
35.7		 1h4oF-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		8 / 8 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
LEU A 116
PHE A 120
ARG A 127
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
None
BEZ  A1162 (-3.7A)
 0.07A 1h4oG-1h4oA:
35.6		 1h4oG-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H4O_H_BEZH1162_0
(PEROXIREDOXIN 5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		9 / 9 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
LEU A 116
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.25A 1h4oH-1h4oA:
34.8		 1h4oH-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HD2_A_BEZA201_0
(PEROXIREDOXIN 5
RESIDUES 54-214)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		5 / 9 GLY A  46
CYH A  47
LEU A 112
ARG A 127
THR A 147
 BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 1.37A 1hd2A-1h4oA:
35.2		 1hd2A-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HD2_A_BEZA201_0
(PEROXIREDOXIN 5
RESIDUES 54-214)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		9 / 9 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
LEU A 116
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.19A 1hd2A-1h4oA:
35.2		 1hd2A-1h4oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		5 / 12 LEU A  73
ILE A 157
PRO A  10
VAL A  12
VAL A 137
 None
 1.42A 1hrkB-1h4oA:
undetectable		 1hrkB-1h4oA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		8 / 8 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.18A 1oc3A-1h4oA:
35.0		 1oc3A-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OC3_B_BEZB201_0
(PEROXIREDOXIN 5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		9 / 9 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
LEU A 116
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.26A 1oc3B-1h4oA:
34.4		 1oc3B-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		8 / 9 PRO A  40
THR A  44
PRO A  45
GLY A  46
LEU A 116
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
None
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.29A 1urmA-1h4oA:
33.8		 1urmA-1h4oA:
99.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		3 / 3 LYS A  63
ARG A  95
VAL A  70
 None
 1.10A 2r2vC-1h4oA:
0.0
2r2vD-1h4oA:
undetectable		 2r2vC-1h4oA:
13.82
2r2vD-1h4oA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		4 / 8 PRO A  40
THR A  44
PRO A  45
ARG A 127
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.7A)
 0.51A 2v32C-1h4oA:
18.7
2v32D-1h4oA:
19.8		 2v32C-1h4oA:
25.86
2v32D-1h4oA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		4 / 8 PRO A  40
THR A  44
PRO A  45
ARG A 127
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.7A)
 0.55A 2v41C-1h4oA:
19.6
2v41D-1h4oA:
19.8		 2v41C-1h4oA:
25.86
2v41D-1h4oA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		4 / 8 PRO A  40
THR A  44
PRO A  45
ARG A 127
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.7A)
 0.54A 2v41C-1h4oA:
19.6
2v41D-1h4oA:
19.8		 2v41C-1h4oA:
25.86
2v41D-1h4oA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		4 / 8 PRO A  40
THR A  44
PRO A  45
ARG A 127
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.7A)
 0.52A 2v41G-1h4oA:
18.4
2v41H-1h4oA:
18.5		 2v41G-1h4oA:
25.86
2v41H-1h4oA:
25.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		9 / 10 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
LEU A 116
PHE A 120
ARG A 127
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
 0.23A 2vl2A-1h4oA:
35.0
2vl2C-1h4oA:
28.6		 2vl2A-1h4oA:
100.00
2vl2C-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		7 / 7 PRO A  40
THR A  44
PRO A  45
GLY A  46
LEU A 116
PHE A 120
THR A 147
 BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
None
None
BEZ  A1162 ( 4.0A)
 0.29A 2vl2B-1h4oA:
34.3		 2vl2B-1h4oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		5 / 8 HIS A  51
LEU A 161
GLN A 160
ILE A 158
LEU A  62
 None
 1.29A 2xfhA-1h4oA:
undetectable		 2xfhA-1h4oA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		3 / 3 VAL A  67
LYS A  63
HIS A  51
 None
 0.93A 3elzA-1h4oA:
0.0		 3elzA-1h4oA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		5 / 12 LEU A  73
ILE A 157
PRO A  10
VAL A  12
VAL A 137
 None
 1.37A 3w1wB-1h4oA:
undetectable		 3w1wB-1h4oA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		4 / 8 GLU A  18
GLU A  16
GLU A  91
ARG A  95
 None
 1.10A 4mj8B-1h4oA:
undetectable
4mj8C-1h4oA:
undetectable		 4mj8B-1h4oA:
19.69
4mj8C-1h4oA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		5 / 9 VAL A  14
VAL A  12
PHE A 104
ILE A   9
PHE A  29
 None
 1.29A 5e4dA-1h4oA:
0.0		 5e4dA-1h4oA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		3 / 3 LYS A 138
LEU A  36
ILE A   3
 None
 0.76A 5kc0A-1h4oA:
undetectable		 5kc0A-1h4oA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		5 / 12 PHE A 128
GLY A 148
GLY A 146
LEU A 149
HIS A  51
 None
 1.17A 5kocB-1h4oA:
undetectable		 5kocB-1h4oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1h4o PEROXIREDOXIN 5
(Homo
sapiens) 		4 / 5 LEU A  25
VAL A  23
GLU A  16
LEU A  97
 None
 1.04A 5xooB-1h4oA:
0.0		 5xooB-1h4oA:
20.30