SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 419
ARG A 391
THR A 340
 None
 1.00A 1df7A-1h4pA:
undetectable		 1df7A-1h4pA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 139
TYR A 210
ILE A 160
VAL A 172
ILE A 134
 None
 1.36A 1gebA-1h4pA:
0.0		 1gebA-1h4pA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 421
ASP A 420
GLY A  59
ILE A  58
ILE A 408
 None
 0.88A 1muiB-1h4pA:
undetectable		 1muiB-1h4pA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.09A 1v55C-1h4pA:
undetectable
1v55N-1h4pA:
0.0
1v55P-1h4pA:
undetectable		 1v55C-1h4pA:
18.60
1v55N-1h4pA:
21.08
1v55P-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 383
GLU A 387
TYR A 439
ARG A 390
 None
 1.42A 1yc2A-1h4pA:
0.5
1yc2B-1h4pA:
1.9
1yc2E-1h4pA:
0.0		 1yc2A-1h4pA:
19.66
1yc2B-1h4pA:
19.66
1yc2E-1h4pA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 200
TYR A  91
SER A 180
 None
 0.94A 2gvcB-1h4pA:
0.0		 2gvcB-1h4pA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 200
TYR A  91
SER A 180
 None
 0.93A 2gvcE-1h4pA:
1.3		 2gvcE-1h4pA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 421
ASP A 420
GLY A  59
ILE A  58
ILE A 408
 None
 0.93A 2q5kA-1h4pA:
undetectable		 2q5kA-1h4pA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 269
PHE A 271
TYR A 274
TRP A 319
 None
 1.30A 2q6kA-1h4pA:
0.0		 2q6kA-1h4pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		6 / 12 ASN A 231
GLU A 232
HIS A 295
TYR A 297
GLU A 334
TRP A 409
 None
GOL  A1450 ( 4.7A)
None
GOL  A1450 ( 4.8A)
GOL  A1450 ( 4.1A)
GOL  A1450 (-3.5A)
 0.73A 2v3dA-1h4pA:
15.8		 2v3dA-1h4pA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 11 ASN A 231
GLU A 232
TYR A 297
GLU A 334
TRP A 409
 None
GOL  A1450 ( 4.7A)
GOL  A1450 ( 4.8A)
GOL  A1450 ( 4.1A)
GOL  A1450 (-3.5A)
 0.82A 2v3dB-1h4pA:
12.7		 2v3dB-1h4pA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 155
LEU A 156
LEU A  62
ALA A 138
 None
 0.97A 2wekA-1h4pA:
undetectable		 2wekA-1h4pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1162_1
(ALLERGEN ARG R 1)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 4 GLU A 334
ASP A 269
HIS A 268
GLU A 228
 GOL  A1450 ( 4.1A)
None
None
None
 1.34A 2x45A-1h4pA:
0.0		 2x45A-1h4pA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.12A 2y69C-1h4pA:
undetectable
2y69N-1h4pA:
0.5
2y69P-1h4pA:
undetectable		 2y69C-1h4pA:
18.60
2y69N-1h4pA:
21.08
2y69P-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.11A 3ablA-1h4pA:
0.3
3ablC-1h4pA:
undetectable
3ablP-1h4pA:
undetectable		 3ablA-1h4pA:
21.08
3ablC-1h4pA:
18.60
3ablP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.10A 3ablC-1h4pA:
undetectable
3ablN-1h4pA:
0.2
3ablP-1h4pA:
undetectable		 3ablC-1h4pA:
18.60
3ablN-1h4pA:
21.08
3ablP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.04A 3abmA-1h4pA:
0.3
3abmC-1h4pA:
undetectable
3abmP-1h4pA:
undetectable		 3abmA-1h4pA:
21.08
3abmC-1h4pA:
18.60
3abmP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.10A 3asnC-1h4pA:
undetectable
3asnN-1h4pA:
0.5
3asnP-1h4pA:
undetectable		 3asnC-1h4pA:
18.60
3asnN-1h4pA:
21.08
3asnP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.09A 3asoA-1h4pA:
undetectable
3asoC-1h4pA:
undetectable
3asoP-1h4pA:
undetectable		 3asoA-1h4pA:
21.08
3asoC-1h4pA:
18.60
3asoP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.13A 3asoC-1h4pA:
undetectable
3asoN-1h4pA:
0.5
3asoP-1h4pA:
undetectable		 3asoC-1h4pA:
18.60
3asoN-1h4pA:
21.08
3asoP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 411
ASP A 118
ASP A 420
ILE A  68
GLY A  59
 None
 1.39A 3myuB-1h4pA:
0.0		 3myuB-1h4pA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 418
ASP A 341
TYR A 355
ASP A 356
 None
 1.50A 3pocB-1h4pA:
8.2		 3pocB-1h4pA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  41
SER A 216
GLN A 263
 None
 1.18A 3si7A-1h4pA:
0.0		 3si7A-1h4pA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 7 ASN A  57
ILE A 408
PHE A 430
MET A 425
 None
 1.03A 3tvxB-1h4pA:
undetectable		 3tvxB-1h4pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.05A 3wg7A-1h4pA:
0.2
3wg7C-1h4pA:
undetectable
3wg7P-1h4pA:
undetectable		 3wg7A-1h4pA:
21.08
3wg7C-1h4pA:
18.60
3wg7P-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.09A 3wg7C-1h4pA:
undetectable
3wg7N-1h4pA:
0.2
3wg7P-1h4pA:
undetectable		 3wg7C-1h4pA:
18.60
3wg7N-1h4pA:
21.08
3wg7P-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.07A 3x2qA-1h4pA:
undetectable
3x2qC-1h4pA:
undetectable
3x2qP-1h4pA:
undetectable		 3x2qA-1h4pA:
21.08
3x2qC-1h4pA:
18.60
3x2qP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.09A 3x2qC-1h4pA:
undetectable
3x2qN-1h4pA:
0.5
3x2qP-1h4pA:
undetectable		 3x2qC-1h4pA:
18.60
3x2qN-1h4pA:
21.08
3x2qP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 220
LYS A 214
LEU A 156
GLU A 153
 None
 1.42A 4olaA-1h4pA:
0.0		 4olaA-1h4pA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 220
LYS A 214
LEU A 156
GLU A 153
 None
 1.23A 4olbA-1h4pA:
1.6		 4olbA-1h4pA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 152
GLY A  60
ASP A 173
GLU A 334
TYR A  67
 None
None
None
GOL  A1450 ( 4.1A)
GOL  A1450 (-4.6A)
 1.13A 4pclA-1h4pA:
undetectable		 4pclA-1h4pA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 106
GLY A  60
ASP A 173
GLU A 334
TYR A  67
 None
None
None
GOL  A1450 ( 4.1A)
GOL  A1450 (-4.6A)
 1.21A 4pclA-1h4pA:
undetectable		 4pclA-1h4pA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 403
GLY A 226
GLY A 404
ASP A  45
ILE A 266
 GOL  A1451 (-4.1A)
None
None
GOL  A1451 (-3.9A)
None
 0.83A 4q5mA-1h4pA:
undetectable		 4q5mA-1h4pA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_1
(BIFUNCTIONAL AAC/APH)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 333
HIS A 294
GLU A 326
ARG A 403
GLU A 228
 None
None
None
GOL  A1451 (-4.1A)
None
 1.45A 4qc6B-1h4pA:
0.5		 4qc6B-1h4pA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 334
TYR A  67
GLU A  65
 GOL  A1450 ( 4.1A)
GOL  A1450 (-4.6A)
GOL  A1450 (-2.9A)
 0.70A 4ryaA-1h4pA:
0.0		 4ryaA-1h4pA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 153
TYR A 210
PHE A 139
TYR A 220
 None
 1.16A 4twdF-1h4pA:
undetectable
4twdJ-1h4pA:
0.0		 4twdF-1h4pA:
21.14
4twdJ-1h4pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 220
GLU A 153
TYR A 210
PHE A 139
 None
 1.17A 4twdG-1h4pA:
undetectable
4twdH-1h4pA:
undetectable		 4twdG-1h4pA:
21.14
4twdH-1h4pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  59
HIS A 109
PHE A  73
ILE A  68
HIS A 175
 None
None
None
None
GOL  A1450 (-4.4A)
 1.36A 4wh5A-1h4pA:
0.0		 4wh5A-1h4pA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  97
LEU A  64
ILE A  86
PHE A  73
 None
 1.27A 4y4dA-1h4pA:
0.0		 4y4dA-1h4pA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 220
LYS A 214
LEU A 156
GLU A 153
 None
 1.24A 4z4cA-1h4pA:
2.2		 4z4cA-1h4pA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 220
LYS A 214
LEU A 156
GLU A 153
 None
 1.22A 4z4dA-1h4pA:
1.3		 4z4dA-1h4pA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 220
LYS A 214
LEU A 156
GLU A 153
 None
 1.34A 4z4hA-1h4pA:
1.0		 4z4hA-1h4pA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 314
ARG A 307
HIS A 312
 None
 1.21A 4zbrA-1h4pA:
0.0		 4zbrA-1h4pA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.06A 5b1aA-1h4pA:
0.3
5b1aC-1h4pA:
undetectable
5b1aP-1h4pA:
undetectable		 5b1aA-1h4pA:
21.08
5b1aC-1h4pA:
18.60
5b1aP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.14A 5b1bA-1h4pA:
0.0
5b1bC-1h4pA:
undetectable
5b1bP-1h4pA:
undetectable		 5b1bA-1h4pA:
21.08
5b1bC-1h4pA:
18.60
5b1bP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.05A 5b3sA-1h4pA:
0.3
5b3sC-1h4pA:
undetectable
5b3sP-1h4pA:
undetectable		 5b3sA-1h4pA:
21.08
5b3sC-1h4pA:
18.60
5b3sP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 226
ILE A 265
LEU A 255
GLY A 289
GLY A 404
 None
None
None
GOL  A1449 (-3.9A)
None
 1.06A 5d4uA-1h4pA:
undetectable		 5d4uA-1h4pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 226
ILE A 265
LEU A 255
GLY A 289
GLY A 404
 None
None
None
GOL  A1449 (-3.9A)
None
 1.06A 5d4uB-1h4pA:
undetectable		 5d4uB-1h4pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 408
GLU A 334
GLY A 333
ARG A 131
GLU A  51
 None
GOL  A1450 ( 4.1A)
None
None
None
 1.38A 5fhzD-1h4pA:
undetectable		 5fhzD-1h4pA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 297
TYR A  67
ILE A  68
PHE A 300
ILE A 407
 GOL  A1450 ( 4.8A)
GOL  A1450 (-4.6A)
None
None
None
 1.11A 5hw8B-1h4pA:
undetectable
5hw8F-1h4pA:
undetectable
5hw8G-1h4pA:
undetectable		 5hw8B-1h4pA:
14.77
5hw8F-1h4pA:
14.77
5hw8G-1h4pA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 173
HIS A 268
GLY A 176
ALA A 177
 None
 1.05A 5hwaA-1h4pA:
0.0		 5hwaA-1h4pA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.14A 5iy5C-1h4pA:
undetectable
5iy5N-1h4pA:
0.1
5iy5P-1h4pA:
undetectable		 5iy5C-1h4pA:
18.16
5iy5N-1h4pA:
21.08
5iy5P-1h4pA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 350
ASP A  83
ASN A  79
 None
 0.61A 5jglA-1h4pA:
undetectable		 5jglA-1h4pA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 220
LYS A 214
LEU A 156
GLU A 153
 None
 1.32A 5js1A-1h4pA:
2.2		 5js1A-1h4pA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 220
ILE A 160
ILE A 223
VAL A 172
ILE A 225
 None
 1.47A 5mvnB-1h4pA:
0.0		 5mvnB-1h4pA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.12A 5wauA-1h4pA:
undetectable
5wauC-1h4pA:
undetectable
5wauc-1h4pA:
undetectable		 5wauA-1h4pA:
21.08
5wauC-1h4pA:
18.60
5wauc-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.11A 5wauC-1h4pA:
undetectable
5waua-1h4pA:
undetectable
5wauc-1h4pA:
undetectable		 5wauC-1h4pA:
18.60
5waua-1h4pA:
21.08
5wauc-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.17A 5x19A-1h4pA:
0.2
5x19C-1h4pA:
undetectable
5x19P-1h4pA:
undetectable		 5x19A-1h4pA:
21.08
5x19C-1h4pA:
18.60
5x19P-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.18A 5x1fA-1h4pA:
0.4
5x1fC-1h4pA:
undetectable
5x1fP-1h4pA:
undetectable		 5x1fA-1h4pA:
21.08
5x1fC-1h4pA:
18.60
5x1fP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.11A 5xdqA-1h4pA:
0.2
5xdqC-1h4pA:
undetectable
5xdqP-1h4pA:
undetectable		 5xdqA-1h4pA:
21.08
5xdqC-1h4pA:
18.60
5xdqP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.10A 5xdqC-1h4pA:
undetectable
5xdqN-1h4pA:
0.4
5xdqP-1h4pA:
undetectable		 5xdqC-1h4pA:
18.60
5xdqN-1h4pA:
21.08
5xdqP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.11A 5xdxC-1h4pA:
undetectable
5xdxN-1h4pA:
0.0
5xdxP-1h4pA:
undetectable		 5xdxC-1h4pA:
17.96
5xdxN-1h4pA:
21.08
5xdxP-1h4pA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.10A 5z84A-1h4pA:
0.3
5z84C-1h4pA:
undetectable
5z84P-1h4pA:
undetectable		 5z84A-1h4pA:
21.08
5z84C-1h4pA:
18.60
5z84P-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 439
ARG A 390
THR A 389
 None
 0.85A 5z84J-1h4pA:
0.0		 5z84J-1h4pA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.08A 5z84C-1h4pA:
undetectable
5z84N-1h4pA:
0.3
5z84P-1h4pA:
undetectable		 5z84C-1h4pA:
18.60
5z84N-1h4pA:
21.08
5z84P-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.07A 5z85A-1h4pA:
0.4
5z85C-1h4pA:
undetectable
5z85P-1h4pA:
undetectable		 5z85A-1h4pA:
21.08
5z85C-1h4pA:
18.60
5z85P-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.09A 5z85C-1h4pA:
undetectable
5z85N-1h4pA:
0.3
5z85P-1h4pA:
undetectable		 5z85C-1h4pA:
18.60
5z85N-1h4pA:
21.08
5z85P-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.11A 5z86A-1h4pA:
0.5
5z86C-1h4pA:
undetectable
5z86P-1h4pA:
undetectable		 5z86A-1h4pA:
21.08
5z86C-1h4pA:
18.60
5z86P-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.11A 5z86C-1h4pA:
undetectable
5z86N-1h4pA:
0.3
5z86P-1h4pA:
undetectable		 5z86C-1h4pA:
18.60
5z86N-1h4pA:
21.08
5z86P-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.07A 5zcoA-1h4pA:
undetectable
5zcoC-1h4pA:
undetectable
5zcoP-1h4pA:
undetectable		 5zcoA-1h4pA:
21.08
5zcoC-1h4pA:
18.60
5zcoP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.06A 5zcoC-1h4pA:
undetectable
5zcoN-1h4pA:
0.2
5zcoP-1h4pA:
undetectable		 5zcoC-1h4pA:
18.60
5zcoN-1h4pA:
21.08
5zcoP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.11A 5zcpA-1h4pA:
0.5
5zcpC-1h4pA:
undetectable
5zcpP-1h4pA:
undetectable		 5zcpA-1h4pA:
21.08
5zcpC-1h4pA:
18.60
5zcpP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 196
ASP A 246
TYR A 247
HIS A 328
 None
None
None
GOL  A1449 ( 4.1A)
 1.10A 5zcpC-1h4pA:
undetectable
5zcpN-1h4pA:
0.2
5zcpP-1h4pA:
undetectable		 5zcpC-1h4pA:
18.60
5zcpN-1h4pA:
21.08
5zcpP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 246
TYR A 247
HIS A 328
LEU A 196
 None
None
GOL  A1449 ( 4.1A)
None
 1.08A 5zcqA-1h4pA:
0.5
5zcqC-1h4pA:
undetectable
5zcqP-1h4pA:
undetectable		 5zcqA-1h4pA:
21.08
5zcqC-1h4pA:
18.60
5zcqP-1h4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 220
LYS A 214
LEU A 156
GLU A 153
 None
 1.19A 6cbdA-1h4pA:
0.0		 6cbdA-1h4pA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 12 TRP A 171
LEU A 129
VAL A  56
ALA A 421
PHE A 335
 None
 1.49A 6drxA-1h4pA:
undetectable		 6drxA-1h4pA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		5 / 12 THR A 204
ASP A 173
HIS A 268
ASN A 186
HIS A 175
 None
None
None
GOL  A1450 (-3.4A)
GOL  A1450 (-4.4A)
 1.34A 6exiD-1h4pA:
undetectable		 6exiD-1h4pA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 269
HIS A 175
HIS A 294
GLU A 334
 None
GOL  A1450 (-4.4A)
None
GOL  A1450 ( 4.1A)
 1.20A 6mn4D-1h4pA:
0.1		 6mn4D-1h4pA:
21.53