SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1h4r MERLIN
(Homo
sapiens) 		5 / 12 VAL A 236
GLY A 235
LEU A 234
TYR A 244
GLY A 240
 None
 1.13A 1fduA-1h4rA:
undetectable		 1fduA-1h4rA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1h4r MERLIN
(Homo
sapiens) 		5 / 12 VAL A 236
GLY A 235
LEU A 234
TYR A 244
GLY A 240
 None
 1.11A 1fduC-1h4rA:
undetectable		 1fduC-1h4rA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 1h4r MERLIN
(Homo
sapiens) 		4 / 7 PRO A 102
ALA A  98
PHE A  62
PHE A  61
 None
 1.23A 1lqtA-1h4rA:
undetectable		 1lqtA-1h4rA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 1h4r MERLIN
(Homo
sapiens) 		4 / 7 PRO A 102
ALA A  98
PHE A  62
PHE A  61
 None
 1.23A 1lquA-1h4rA:
undetectable		 1lquA-1h4rA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1h4r MERLIN
(Homo
sapiens) 		4 / 8 PHE A  61
GLY A  63
THR A  28
PHE A  96
 None
 1.08A 1ykiA-1h4rA:
0.0
1ykiB-1h4rA:
0.0		 1ykiA-1h4rA:
23.46
1ykiB-1h4rA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1h4r MERLIN
(Homo
sapiens) 		4 / 8 THR A  28
PHE A  96
PHE A  61
GLY A  63
 None
 1.08A 1ykiA-1h4rA:
0.0
1ykiB-1h4rA:
0.0		 1ykiA-1h4rA:
23.46
1ykiB-1h4rA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1h4r MERLIN
(Homo
sapiens) 		4 / 8 PHE A  61
GLY A  63
THR A  28
PHE A  96
 None
 1.07A 1ykiC-1h4rA:
0.0
1ykiD-1h4rA:
0.0		 1ykiC-1h4rA:
23.46
1ykiD-1h4rA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1h4r MERLIN
(Homo
sapiens) 		4 / 8 THR A  28
PHE A  96
PHE A  61
GLY A  63
 None
 1.08A 1ykiC-1h4rA:
0.0
1ykiD-1h4rA:
0.0		 1ykiC-1h4rA:
23.46
1ykiD-1h4rA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 1h4r MERLIN
(Homo
sapiens) 		5 / 12 LEU A 241
GLY A 218
GLY A 235
LEU A 234
PHE A 222
 None
 1.20A 3e23A-1h4rA:
undetectable		 3e23A-1h4rA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1h4r MERLIN
(Homo
sapiens) 		4 / 5 SER A 143
ALA A 142
HIS A 195
LEU A 140
 None
None
SO4  A1315 (-3.9A)
None
 1.22A 5dzkb-1h4rA:
undetectable
5dzkp-1h4rA:
undetectable		 5dzkb-1h4rA:
20.67
5dzkp-1h4rA:
0.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1h4r MERLIN
(Homo
sapiens) 		4 / 5 SER A 143
ALA A 142
HIS A 195
LEU A 140
 None
None
SO4  A1315 (-3.9A)
None
 1.24A 5dzkc-1h4rA:
undetectable
5dzkq-1h4rA:
undetectable		 5dzkc-1h4rA:
20.67
5dzkq-1h4rA:
0.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 1h4r MERLIN
(Homo
sapiens) 		4 / 6 GLU A 166
ALA A 164
LEU A 163
TYR A 150
 None
 0.92A 5phhA-1h4rA:
0.0		 5phhA-1h4rA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 1h4r MERLIN
(Homo
sapiens) 		4 / 6 ARG A 200
PHE A 162
ILE A 188
THR A 189
 None
 1.02A 5vceA-1h4rA:
0.0		 5vceA-1h4rA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 1h4r MERLIN
(Homo
sapiens) 		5 / 12 LEU A 295
ILE A 296
CYH A 300
PHE A 100
VAL A  27
 None
 1.23A 6a7pA-1h4rA:
0.0		 6a7pA-1h4rA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1h4r MERLIN
(Homo
sapiens) 		4 / 6 VAL A  24
LEU A  75
LEU A  64
HIS A  95
 None
 1.03A 6e43B-1h4rA:
0.0		 6e43B-1h4rA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1h4r MERLIN
(Homo
sapiens) 		3 / 3 TYR A 217
ASP A 213
GLN A 212
 None
 0.73A 6g1pA-1h4rA:
0.0		 6g1pA-1h4rA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1h4r MERLIN
(Homo
sapiens) 		5 / 12 ASN A 220
LEU A 299
LEU A  97
GLY A  63
PHE A  62
 None
 1.28A 6r2eA-1h4rA:
0.0		 6r2eA-1h4rA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 1h4r MERLIN
(Homo
sapiens) 		5 / 11 ASN A 220
LEU A 299
LEU A  97
GLY A  63
PHE A  62
 None
 1.22A 6r2eG-1h4rA:
0.0		 6r2eG-1h4rA:
23.16