SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 1h4u NIDOGEN-1
(Mus
musculus) 		5 / 12 ILE A 518
LEU A 503
ASN A 625
VAL A 605
TYR A 540
 None
 1.21A 1mrlB-1h4uA:
undetectable
1mrlC-1h4uA:
undetectable		 1mrlB-1h4uA:
19.49
1mrlC-1h4uA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 5 GLN A 505
PHE A 507
PHE A 486
GLY A 465
 None
 1.33A 2qmzA-1h4uA:
undetectable
2qmzB-1h4uA:
undetectable		 2qmzA-1h4uA:
23.13
2qmzB-1h4uA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 1h4u NIDOGEN-1
(Mus
musculus) 		3 / 3 SER A 599
TYR A 546
HIS A 545
 None
 0.72A 2r2vD-1h4uA:
undetectable		 2r2vD-1h4uA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 7 ILE A 460
GLY A 461
PHE A 507
ILE A 518
 None
 0.65A 2y7wC-1h4uA:
undetectable		 2y7wC-1h4uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 7 SER A 430
LEU A 623
SER A 439
THR A 441
 None
 0.79A 3cfqA-1h4uA:
undetectable
3cfqB-1h4uA:
undetectable		 3cfqA-1h4uA:
19.28
3cfqB-1h4uA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1h4u NIDOGEN-1
(Mus
musculus) 		5 / 12 GLN A 505
VAL A 408
ILE A 412
LEU A 454
PHE A 423
 None
 1.19A 3datA-1h4uA:
undetectable		 3datA-1h4uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 5 TYR A 577
ILE A 460
TYR A 621
THR A 441
 None
 1.31A 3dgqA-1h4uA:
undetectable		 3dgqA-1h4uA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1h4u NIDOGEN-1
(Mus
musculus) 		3 / 3 GLU A 485
SER A 368
VAL A 369
 None
 0.79A 3eeoA-1h4uA:
undetectable		 3eeoA-1h4uA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 7 TYR A 546
LEU A 597
PHE A 585
TRP A 466
 None
 1.10A 3nk2X-1h4uA:
undetectable		 3nk2X-1h4uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1h4u NIDOGEN-1
(Mus
musculus) 		5 / 12 LEU A 623
GLU A 471
ALA A 469
GLY A 465
LEU A 603
 None
 1.18A 3ou6C-1h4uA:
undetectable		 3ou6C-1h4uA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 8 GLY A 461
ILE A 464
ILE A 518
THR A 441
 None
 0.84A 4em2A-1h4uA:
undetectable		 4em2A-1h4uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 7 LEU A 623
SER A 439
THR A 441
SER A 430
 None
 0.85A 4ikjA-1h4uA:
0.0
4ikjB-1h4uA:
0.0		 4ikjA-1h4uA:
18.80
4ikjB-1h4uA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 8 SER A 430
LEU A 623
SER A 439
THR A 441
 None
 0.83A 4ikjA-1h4uA:
undetectable
4ikjB-1h4uA:
undetectable		 4ikjA-1h4uA:
18.80
4ikjB-1h4uA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 8 LEU A 623
SER A 439
THR A 441
SER A 430
 None
 0.81A 4ikkA-1h4uA:
undetectable
4ikkB-1h4uA:
undetectable		 4ikkA-1h4uA:
18.80
4ikkB-1h4uA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 7 SER A 430
LEU A 623
SER A 439
THR A 441
 None
 0.84A 4ikkA-1h4uA:
undetectable
4ikkB-1h4uA:
undetectable		 4ikkA-1h4uA:
18.80
4ikkB-1h4uA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1h4u NIDOGEN-1
(Mus
musculus) 		5 / 6 ILE A 460
ALA A 442
THR A 441
VAL A 408
HIS A 429
 None
 1.23A 5eclD-1h4uA:
0.0		 5eclD-1h4uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 7 LEU A 457
TYR A 540
GLU A 542
SER A 555
 None
 1.21A 5umwA-1h4uA:
0.8
5umwF-1h4uA:
0.3		 5umwA-1h4uA:
14.29
5umwF-1h4uA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 8 THR A 482
TRP A 466
ASN A 477
PHE A 468
 None
 1.32A 5v4vA-1h4uA:
undetectable		 5v4vA-1h4uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 1h4u NIDOGEN-1
(Mus
musculus) 		4 / 8 THR A 482
TRP A 466
ASN A 477
PHE A 468
 None
 1.32A 5v4vB-1h4uA:
undetectable		 5v4vB-1h4uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1h4u NIDOGEN-1
(Mus
musculus) 		5 / 6 PRO A 530
GLY A 532
TYR A 531
LEU A 455
VAL A 561
 None
 1.44A 5x80A-1h4uA:
0.0
5x80B-1h4uA:
0.0		 5x80A-1h4uA:
21.24
5x80B-1h4uA:
21.24