SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4S_A_TPVA201_2 (PROTEIN (HIV-1 PROTEASE))	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 8	ARG B 266 ALA B 143 ILE B 138 VAL B 303	None	0.74A	1d4sB-1h4vB: undetectable	1d4sB-1h4vB: 12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DZ4_A_CAMA502_0 (CYTOCHROME P450-CAM)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 6	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.03A	1dz4A-1h4vB: 0.0	1dz4A-1h4vB: 24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DZ4_B_CAMB502_0 (CYTOCHROME P450-CAM)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 6	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.06A	1dz4B-1h4vB: 0.0	1dz4B-1h4vB: 24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DZ6_B_CAMB502_0 (CYTOCHROME P450-CAM)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 5	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.06A	1dz6B-1h4vB: 0.0	1dz6B-1h4vB: 24.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1HTT_A_HISA450_0 (HISTIDYL-TRNA SYNTHETASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	5 / 10	GLU B 81 THR B 83 GLN B 126 GLU B 130 GLY B 285	None	0.75A	1httA-1h4vB: 33.9	1httA-1h4vB: 42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1HTT_A_HISA450_0 (HISTIDYL-TRNA SYNTHETASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	5 / 10	GLU B 81 THR B 83 GLN B 126 GLU B 130 TYR B 264	None	0.90A	1httA-1h4vB: 33.9	1httA-1h4vB: 42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1HTT_B_HISB450_0 (HISTIDYL-TRNA SYNTHETASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	7 / 12	GLU B 81 THR B 83 GLN B 126 GLU B 130 GLY B 285 TYR B 288 GLY B 304	None	0.65A	1httB-1h4vB: 32.6	1httB-1h4vB: 42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1HTT_B_HISB450_0 (HISTIDYL-TRNA SYNTHETASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	6 / 12	GLU B 81 THR B 83 GLN B 126 GLU B 130 TYR B 264 TYR B 288	None	0.90A	1httB-1h4vB: 32.6	1httB-1h4vB: 42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1HTT_B_HISB450_0 (HISTIDYL-TRNA SYNTHETASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	7 / 12	GLU B 81 THR B 83 GLU B 130 ARG B 259 GLY B 285 TYR B 288 GLY B 304	None	1.10A	1httB-1h4vB: 32.6	1httB-1h4vB: 42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1HTT_C_HISC450_0 (HISTIDYL-TRNA SYNTHETASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	6 / 12	GLN B 126 TYR B 264 GLY B 285 TYR B 288 GLY B 304 ALA B 306	None	1.13A	1httC-1h4vB: 34.0	1httC-1h4vB: 42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1HTT_C_HISC450_0 (HISTIDYL-TRNA SYNTHETASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	8 / 12	GLU B 81 THR B 83 GLN B 126 GLU B 130 GLY B 285 TYR B 288 GLY B 304 ALA B 306	None	0.64A	1httC-1h4vB: 34.0	1httC-1h4vB: 42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1HTT_C_HISC450_0 (HISTIDYL-TRNA SYNTHETASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	7 / 12	GLU B 81 THR B 83 GLN B 126 GLU B 130 TYR B 264 TYR B 288 ALA B 306	None	0.80A	1httC-1h4vB: 34.0	1httC-1h4vB: 42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1HTT_C_HISC450_0 (HISTIDYL-TRNA SYNTHETASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	7 / 12	THR B 83 GLU B 130 ARG B 259 GLY B 285 TYR B 288 GLY B 304 ALA B 306	None	0.98A	1httC-1h4vB: 34.0	1httC-1h4vB: 42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1HTT_D_HISD450_0 (HISTIDYL-TRNA SYNTHETASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	5 / 12	GLN B 126 TYR B 264 GLY B 285 GLY B 304 ALA B 306	None	0.97A	1httD-1h4vB: 32.6	1httD-1h4vB: 42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1HTT_D_HISD450_0 (HISTIDYL-TRNA SYNTHETASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	7 / 12	GLU B 81 THR B 83 GLN B 126 GLU B 130 GLY B 285 GLY B 304 ALA B 306	None	0.67A	1httD-1h4vB: 32.6	1httD-1h4vB: 42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1HTT_D_HISD450_0 (HISTIDYL-TRNA SYNTHETASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	6 / 12	GLU B 81 THR B 83 GLN B 126 GLU B 130 TYR B 264 ALA B 306	None	0.91A	1httD-1h4vB: 32.6	1httD-1h4vB: 42.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HZ4_A_BEZA784_0 (MALT REGULATORY PROTEIN)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 6	LEU B 229 LEU B 226 PRO B 224 MET B 225	None	1.30A	1hz4A-1h4vB: undetectable	1hz4A-1h4vB: 23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L2I_B_CCSB417_0 (ESTROGEN RECEPTOR)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 6	PRO B 80 PHE B 111 GLU B 114 LYS B 63	None	1.35A	1l2iB-1h4vB: 0.6	1l2iB-1h4vB: 20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XL6_B_SPMB3001_1 (INWARD RECTIFIER POTASSIUM CHANNEL)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 5	ALA B 177 TYR B 178 ALA B 173 TYR B 175	None	1.15A	1xl6A-1h4vB: 0.0 1xl6B-1h4vB: 0.0	1xl6A-1h4vB: 21.33 1xl6B-1h4vB: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FEU_B_CAMB1421_0 (CYTOCHROME P450-CAM)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 7	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.03A	2feuB-1h4vB: 0.0	2feuB-1h4vB: 23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEK_A_DIFA1375_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	3 / 3	LEU B 416 TYR B 415 GLN B 418	None	0.73A	2wekA-1h4vB: undetectable	2wekA-1h4vB: 24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WLK_B_SPMB1302_1 (ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 4	ALA B 177 TYR B 178 ALA B 173 TYR B 175	None	1.14A	2wlkA-1h4vB: 0.0 2wlkB-1h4vB: 0.0	2wlkA-1h4vB: 21.33 2wlkB-1h4vB: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZAX_A_CAMA422_0 (CYTOCHROME P450-CAM)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 7	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.07A	2zaxA-1h4vB: 0.0	2zaxA-1h4vB: 24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FPJ_B_SAMB301_1 (PUTATIVE UNCHARACTERIZED PROTEIN)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 7	GLY B 304 GLY B 302 THR B 267 ALA B 143	None	0.75A	3fpjB-1h4vB: undetectable	3fpjB-1h4vB: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FWG_A_CAMA420_0 (CAMPHOR 5-MONOOXYGENASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 6	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.06A	3fwgA-1h4vB: 0.0	3fwgA-1h4vB: 23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FWG_B_CAMB420_0 (CAMPHOR 5-MONOOXYGENASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 7	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.07A	3fwgB-1h4vB: undetectable	3fwgB-1h4vB: 23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K2H_A_LYAA514_1 (DIHYDROFOLATE REDUCTASE/THYMIDYLAT E SYNTHASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	5 / 12	PHE B 307 LEU B 282 ARG B 311 ILE B 23 LEU B 156	None	1.09A	3k2hA-1h4vB: undetectable	3k2hA-1h4vB: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_O_TFPO201_1 (PROTEIN S100-A4)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 8	GLY B 308 PHE B 305 GLY B 284 PHE B 269	None	0.95A	3ko0O-1h4vB: 1.3 3ko0Q-1h4vB: 1.2	3ko0O-1h4vB: 13.86 3ko0Q-1h4vB: 13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RGL_A_GLYA301_0 (GLYCYL-TRNA SYNTHETASE ALPHA SUBUNIT)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 8	GLY B 82 THR B 83 GLN B 126 GLU B 130	None	0.82A	3rglA-1h4vB: 10.5	3rglA-1h4vB: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRH_E_CAME503_0 (CAMPHOR 5-MONOOXYGENASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 6	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.05A	3wrhE-1h4vB: 0.0	3wrhE-1h4vB: 24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRJ_E_CAME503_0 (CAMPHOR 5-MONOOXYGENASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 6	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.05A	3wrjE-1h4vB: 0.0	3wrjE-1h4vB: 24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRL_E_CAME503_0 (CAMPHOR 5-MONOOXYGENASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 7	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.03A	3wrlE-1h4vB: 0.0	3wrlE-1h4vB: 24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRM_F_CAMF503_0 (CAMPHOR 5-MONOOXYGENASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 7	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.04A	3wrmF-1h4vB: 0.0	3wrmF-1h4vB: 24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EK1_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 6	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.08A	4ek1A-1h4vB: 0.0	4ek1A-1h4vB: 24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G3R_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 6	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.06A	4g3rA-1h4vB: 0.0	4g3rA-1h4vB: 24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G3R_B_CAMB502_0 (CAMPHOR 5-MONOOXYGENASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 6	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.02A	4g3rB-1h4vB: 0.0	4g3rB-1h4vB: 24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4C_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 6	PHE B 228 TYR B 175 VAL B 182 ASP B 227	None	1.09A	4l4cA-1h4vB: 0.0	4l4cA-1h4vB: 24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OR0_A_NPSA603_1 (SERUM ALBUMIN)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	5 / 11	ARG B 398 LEU B 416 LEU B 333 LEU B 420 LEU B 351	None	1.35A	4or0A-1h4vB: 0.5	4or0A-1h4vB: 24.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RDX_A_HISA502_0 (HISTIDINE--TRNA LIGASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	7 / 7	THR B 83 GLU B 130 ARG B 259 TYR B 264 GLY B 285 TYR B 288 GLY B 304	None	0.61A	4rdxA-1h4vB: 47.1	4rdxA-1h4vB: 99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RDX_A_HISA502_0 (HISTIDINE--TRNA LIGASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	6 / 7	THR B 83 GLU B 130 ARG B 259 TYR B 264 GLY B 286 GLY B 304	None	1.37A	4rdxA-1h4vB: 47.1	4rdxA-1h4vB: 99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5E3I_A_HISA502_0 (HISTIDINE--TRNA LIGASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	8 / 12	GLU B 81 THR B 83 GLN B 126 GLU B 130 GLY B 285 TYR B 288 GLY B 304 ALA B 306	None	0.69A	5e3iA-1h4vB: 35.0	5e3iA-1h4vB: 38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5E3I_A_HISA502_0 (HISTIDINE--TRNA LIGASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	7 / 12	GLU B 81 THR B 83 GLN B 126 GLU B 130 TYR B 264 TYR B 288 ALA B 306	None	0.89A	5e3iA-1h4vB: 35.0	5e3iA-1h4vB: 38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5E3I_A_HISA502_0 (HISTIDINE--TRNA LIGASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	5 / 12	TYR B 264 GLY B 285 TYR B 288 GLY B 304 ALA B 306	None	0.98A	5e3iA-1h4vB: 35.0	5e3iA-1h4vB: 38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5E3I_B_HISB502_0 (HISTIDINE--TRNA LIGASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	8 / 11	GLU B 81 THR B 83 GLN B 126 GLU B 130 GLY B 285 TYR B 288 GLY B 304 ALA B 306	None	0.69A	5e3iB-1h4vB: 36.1	5e3iB-1h4vB: 38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5E3I_B_HISB502_0 (HISTIDINE--TRNA LIGASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	7 / 11	GLU B 81 THR B 83 GLN B 126 GLU B 130 TYR B 264 TYR B 288 ALA B 306	None	0.89A	5e3iB-1h4vB: 36.1	5e3iB-1h4vB: 38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5E3I_B_HISB502_0 (HISTIDINE--TRNA LIGASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	5 / 11	TYR B 264 GLY B 285 TYR B 288 GLY B 304 ALA B 306	None	0.98A	5e3iB-1h4vB: 36.1	5e3iB-1h4vB: 38.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SXT_A_NIZA807_1 (CATALASE-PEROXIDASE)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	4 / 8	GLU B 170 VAL B 265 GLY B 230 LEU B 229	None	1.00A	5sxtA-1h4vB: undetectable	5sxtA-1h4vB: 21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TWJ_C_SAMC201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	5 / 12	LEU B 154 ILE B 23 LEU B 156 LEU B 282 VAL B 312	None	1.15A	5twjC-1h4vB: undetectable	5twjC-1h4vB: 17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TWJ_C_SAMC201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	5 / 12	LEU B 291 GLY B 302 LEU B 295 LEU B 91 VAL B 87	None	1.02A	5twjC-1h4vB: undetectable	5twjC-1h4vB: 17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VEU_A_RITA602_2 (CYTOCHROME P450 3A5)	1h4v	HISTIDYL-TRNA SYNTHETASE (Thermus thermophilus)	3 / 3	ARG B 266 PHE B 305 LEU B 163	None	0.86A	5veuA-1h4vB: undetectable	5veuA-1h4vB: 23.40

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D4S_A_TPVA201_2","PROTEIN (HIV-1 PROTEASE);PROTEIN (HIV-1 PROTEASE)","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"ARG B 266;ALA B 143;ILE B 138;VAL B 303","None","0.74A","1d4sB-1h4vB:undetectable","1d4sB-1h4vB:12.63"],["1DZ4_A_CAMA502_0","CYTOCHROME P450-CAM","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.03A","1dz4A-1h4vB:0.0","1dz4A-1h4vB:24.07"],["1DZ4_B_CAMB502_0","CYTOCHROME P450-CAM","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.06A","1dz4B-1h4vB:0.0","1dz4B-1h4vB:24.07"],["1DZ6_B_CAMB502_0","CYTOCHROME P450-CAM","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.06A","1dz6B-1h4vB:0.0","1dz6B-1h4vB:24.07"],["1HTT_A_HISA450_0","HISTIDYL-TRNA SYNTHETASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",5,"GLU B  81;THR B  83;GLN B 126;GLU B 130;GLY B 285","None","0.75A","1httA-1h4vB:33.9","1httA-1h4vB:42.73"],["1HTT_A_HISA450_0","HISTIDYL-TRNA SYNTHETASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",5,"GLU B  81;THR B  83;GLN B 126;GLU B 130;TYR B 264","None","0.90A","1httA-1h4vB:33.9","1httA-1h4vB:42.73"],["1HTT_B_HISB450_0","HISTIDYL-TRNA SYNTHETASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",7,"GLU B  81;THR B  83;GLN B 126;GLU B 130;GLY B 285;TYR B 288;GLY B 304","None","0.65A","1httB-1h4vB:32.6","1httB-1h4vB:42.73"],["1HTT_B_HISB450_0","HISTIDYL-TRNA SYNTHETASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",6,"GLU B  81;THR B  83;GLN B 126;GLU B 130;TYR B 264;TYR B 288","None","0.90A","1httB-1h4vB:32.6","1httB-1h4vB:42.73"],["1HTT_B_HISB450_0","HISTIDYL-TRNA SYNTHETASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",7,"GLU B  81;THR B  83;GLU B 130;ARG B 259;GLY B 285;TYR B 288;GLY B 304","None","1.10A","1httB-1h4vB:32.6","1httB-1h4vB:42.73"],["1HTT_C_HISC450_0","HISTIDYL-TRNA SYNTHETASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",6,"GLN B 126;TYR B 264;GLY B 285;TYR B 288;GLY B 304;ALA B 306","None","1.13A","1httC-1h4vB:34.0","1httC-1h4vB:42.73"],["1HTT_C_HISC450_0","HISTIDYL-TRNA SYNTHETASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",8,"GLU B  81;THR B  83;GLN B 126;GLU B 130;GLY B 285;TYR B 288;GLY B 304;ALA B 306","None","0.64A","1httC-1h4vB:34.0","1httC-1h4vB:42.73"],["1HTT_C_HISC450_0","HISTIDYL-TRNA SYNTHETASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",7,"GLU B  81;THR B  83;GLN B 126;GLU B 130;TYR B 264;TYR B 288;ALA B 306","None","0.80A","1httC-1h4vB:34.0","1httC-1h4vB:42.73"],["1HTT_C_HISC450_0","HISTIDYL-TRNA SYNTHETASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",7,"THR B  83;GLU B 130;ARG B 259;GLY B 285;TYR B 288;GLY B 304;ALA B 306","None","0.98A","1httC-1h4vB:34.0","1httC-1h4vB:42.73"],["1HTT_D_HISD450_0","HISTIDYL-TRNA SYNTHETASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",5,"GLN B 126;TYR B 264;GLY B 285;GLY B 304;ALA B 306","None","0.97A","1httD-1h4vB:32.6","1httD-1h4vB:42.73"],["1HTT_D_HISD450_0","HISTIDYL-TRNA SYNTHETASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",7,"GLU B  81;THR B  83;GLN B 126;GLU B 130;GLY B 285;GLY B 304;ALA B 306","None","0.67A","1httD-1h4vB:32.6","1httD-1h4vB:42.73"],["1HTT_D_HISD450_0","HISTIDYL-TRNA SYNTHETASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",6,"GLU B  81;THR B  83;GLN B 126;GLU B 130;TYR B 264;ALA B 306","None","0.91A","1httD-1h4vB:32.6","1httD-1h4vB:42.73"],["1HZ4_A_BEZA784_0","MALT REGULATORY PROTEIN","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"LEU B 229;LEU B 226;PRO B 224;MET B 225","None","1.30A","1hz4A-1h4vB:undetectable","1hz4A-1h4vB:23.13"],["1L2I_B_CCSB417_0","ESTROGEN RECEPTOR","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PRO B  80;PHE B 111;GLU B 114;LYS B  63","None","1.35A","1l2iB-1h4vB:0.6","1l2iB-1h4vB:20.10"],["1XL6_B_SPMB3001_1","INWARD RECTIFIER POTASSIUM CHANNEL;INWARD RECTIFIER POTASSIUM CHANNEL","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"ALA B 177;TYR B 178;ALA B 173;TYR B 175","None","1.15A","1xl6A-1h4vB:0.0;1xl6B-1h4vB:0.0","1xl6A-1h4vB:21.33;1xl6B-1h4vB:21.33"],["2FEU_B_CAMB1421_0","CYTOCHROME P450-CAM","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.03A","2feuB-1h4vB:0.0","2feuB-1h4vB:23.62"],["2WEK_A_DIFA1375_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",3,"LEU B 416;TYR B 415;GLN B 418","None","0.73A","2wekA-1h4vB:undetectable","2wekA-1h4vB:24.26"],["2WLK_B_SPMB1302_1","ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10;ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"ALA B 177;TYR B 178;ALA B 173;TYR B 175","None","1.14A","2wlkA-1h4vB:0.0;2wlkB-1h4vB:0.0","2wlkA-1h4vB:21.33;2wlkB-1h4vB:21.33"],["2ZAX_A_CAMA422_0","CYTOCHROME P450-CAM","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.07A","2zaxA-1h4vB:0.0","2zaxA-1h4vB:24.48"],["3FPJ_B_SAMB301_1","PUTATIVE UNCHARACTERIZED PROTEIN","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"GLY B 304;GLY B 302;THR B 267;ALA B 143","None","0.75A","3fpjB-1h4vB:undetectable","3fpjB-1h4vB:22.43"],["3FWG_A_CAMA420_0","CAMPHOR 5-MONOOXYGENASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.06A","3fwgA-1h4vB:0.0","3fwgA-1h4vB:23.62"],["3FWG_B_CAMB420_0","CAMPHOR 5-MONOOXYGENASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.07A","3fwgB-1h4vB:undetectable","3fwgB-1h4vB:23.62"],["3K2H_A_LYAA514_1","DIHYDROFOLATE REDUCTASE\/THYMIDYLATE SYNTHASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",5,"PHE B 307;LEU B 282;ARG B 311;ILE B  23;LEU B 156","None","1.09A","3k2hA-1h4vB:undetectable","3k2hA-1h4vB:21.93"],["3KO0_O_TFPO201_1","PROTEIN S100-A4;PROTEIN S100-A4","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"GLY B 308;PHE B 305;GLY B 284;PHE B 269","None","0.95A","3ko0O-1h4vB:1.3;3ko0Q-1h4vB:1.2","3ko0O-1h4vB:13.86;3ko0Q-1h4vB:13.86"],["3RGL_A_GLYA301_0","GLYCYL-TRNA SYNTHETASE ALPHA SUBUNIT","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"GLY B  82;THR B  83;GLN B 126;GLU B 130","None","0.82A","3rglA-1h4vB:10.5","3rglA-1h4vB:22.30"],["3WRH_E_CAME503_0","CAMPHOR 5-MONOOXYGENASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.05A","3wrhE-1h4vB:0.0","3wrhE-1h4vB:24.48"],["3WRJ_E_CAME503_0","CAMPHOR 5-MONOOXYGENASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.05A","3wrjE-1h4vB:0.0","3wrjE-1h4vB:24.48"],["3WRL_E_CAME503_0","CAMPHOR 5-MONOOXYGENASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.03A","3wrlE-1h4vB:0.0","3wrlE-1h4vB:24.48"],["3WRM_F_CAMF503_0","CAMPHOR 5-MONOOXYGENASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.04A","3wrmF-1h4vB:0.0","3wrmF-1h4vB:24.48"],["4EK1_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.08A","4ek1A-1h4vB:0.0","4ek1A-1h4vB:24.27"],["4G3R_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.06A","4g3rA-1h4vB:0.0","4g3rA-1h4vB:24.27"],["4G3R_B_CAMB502_0","CAMPHOR 5-MONOOXYGENASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.02A","4g3rB-1h4vB:0.0","4g3rB-1h4vB:24.27"],["4L4C_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"PHE B 228;TYR B 175;VAL B 182;ASP B 227","None","1.09A","4l4cA-1h4vB:0.0","4l4cA-1h4vB:24.48"],["4OR0_A_NPSA603_1","SERUM ALBUMIN","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",5,"ARG B 398;LEU B 416;LEU B 333;LEU B 420;LEU B 351","None","1.35A","4or0A-1h4vB:0.5","4or0A-1h4vB:24.29"],["4RDX_A_HISA502_0","HISTIDINE--TRNA LIGASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",7,"THR B  83;GLU B 130;ARG B 259;TYR B 264;GLY B 285;TYR B 288;GLY B 304","None","0.61A","4rdxA-1h4vB:47.1","4rdxA-1h4vB:99.76"],["4RDX_A_HISA502_0","HISTIDINE--TRNA LIGASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",6,"THR B  83;GLU B 130;ARG B 259;TYR B 264;GLY B 286;GLY B 304","None","1.37A","4rdxA-1h4vB:47.1","4rdxA-1h4vB:99.76"],["5E3I_A_HISA502_0","HISTIDINE--TRNA LIGASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",8,"GLU B  81;THR B  83;GLN B 126;GLU B 130;GLY B 285;TYR B 288;GLY B 304;ALA B 306","None","0.69A","5e3iA-1h4vB:35.0","5e3iA-1h4vB:38.29"],["5E3I_A_HISA502_0","HISTIDINE--TRNA LIGASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",7,"GLU B  81;THR B  83;GLN B 126;GLU B 130;TYR B 264;TYR B 288;ALA B 306","None","0.89A","5e3iA-1h4vB:35.0","5e3iA-1h4vB:38.29"],["5E3I_A_HISA502_0","HISTIDINE--TRNA LIGASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",5,"TYR B 264;GLY B 285;TYR B 288;GLY B 304;ALA B 306","None","0.98A","5e3iA-1h4vB:35.0","5e3iA-1h4vB:38.29"],["5E3I_B_HISB502_0","HISTIDINE--TRNA LIGASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",8,"GLU B  81;THR B  83;GLN B 126;GLU B 130;GLY B 285;TYR B 288;GLY B 304;ALA B 306","None","0.69A","5e3iB-1h4vB:36.1","5e3iB-1h4vB:38.29"],["5E3I_B_HISB502_0","HISTIDINE--TRNA LIGASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",7,"GLU B  81;THR B  83;GLN B 126;GLU B 130;TYR B 264;TYR B 288;ALA B 306","None","0.89A","5e3iB-1h4vB:36.1","5e3iB-1h4vB:38.29"],["5E3I_B_HISB502_0","HISTIDINE--TRNA LIGASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",5,"TYR B 264;GLY B 285;TYR B 288;GLY B 304;ALA B 306","None","0.98A","5e3iB-1h4vB:36.1","5e3iB-1h4vB:38.29"],["5SXT_A_NIZA807_1","CATALASE-PEROXIDASE","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",4,"GLU B 170;VAL B 265;GLY B 230;LEU B 229","None","1.00A","5sxtA-1h4vB:undetectable","5sxtA-1h4vB:21.86"],["5TWJ_C_SAMC201_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",5,"LEU B 154;ILE B  23;LEU B 156;LEU B 282;VAL B 312","None","1.15A","5twjC-1h4vB:undetectable","5twjC-1h4vB:17.80"],["5TWJ_C_SAMC201_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",5,"LEU B 291;GLY B 302;LEU B 295;LEU B  91;VAL B  87","None","1.02A","5twjC-1h4vB:undetectable","5twjC-1h4vB:17.80"],["5VEU_A_RITA602_2","CYTOCHROME P450 3A5","1h4v","HISTIDYL-TRNA SYNTHETASE","Thermus thermophilus",3,"ARG B 266;PHE B 305;LEU B 163","None","0.86A","5veuA-1h4vB:undetectable","5veuA-1h4vB:23.40"]]