SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 1h4y ANTI-SIGMA F FACTOR
ANTAGONIST
(Lysinibacillus
sphaericus) 		5 / 12 MET A  99
LEU A  79
VAL A  14
MET A  55
LEU A  52
 None
 1.24A 1nhzA-1h4yA:
undetectable		 1nhzA-1h4yA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1h4y ANTI-SIGMA F FACTOR
ANTAGONIST
(Lysinibacillus
sphaericus) 		5 / 10 GLY A  61
VAL A  60
VAL A  63
LEU A  21
LEU A  79
 None
 1.30A 4yb6A-1h4yA:
undetectable
4yb6E-1h4yA:
undetectable		 4yb6A-1h4yA:
17.61
4yb6E-1h4yA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1h4y ANTI-SIGMA F FACTOR
ANTAGONIST
(Lysinibacillus
sphaericus) 		5 / 10 GLY A  61
VAL A  60
VAL A  63
LEU A  21
LEU A  79
 None
 1.30A 4yb6B-1h4yA:
0.0
4yb6C-1h4yA:
undetectable		 4yb6B-1h4yA:
17.61
4yb6C-1h4yA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1h4y ANTI-SIGMA F FACTOR
ANTAGONIST
(Lysinibacillus
sphaericus) 		5 / 10 LEU A  21
LEU A  79
GLY A  61
VAL A  60
VAL A  63
 None
 1.29A 4yb6B-1h4yA:
0.0
4yb6F-1h4yA:
undetectable		 4yb6B-1h4yA:
17.61
4yb6F-1h4yA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 1h4y ANTI-SIGMA F FACTOR
ANTAGONIST
(Lysinibacillus
sphaericus) 		3 / 3 TRP A  47
ARG A  66
LEU A   5
 None
 0.61A 5dbyA-1h4yA:
undetectable		 5dbyA-1h4yA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1h4y ANTI-SIGMA F FACTOR
ANTAGONIST
(Lysinibacillus
sphaericus) 		5 / 12 MET A  99
LEU A  79
VAL A  14
MET A  55
LEU A  52
 None
 1.26A 5uc3B-1h4yA:
undetectable		 5uc3B-1h4yA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1h4y ANTI-SIGMA F FACTOR
ANTAGONIST
(Lysinibacillus
sphaericus) 		5 / 12 GLY A  59
VAL A  42
LEU A  70
PHE A  90
ILE A  15
 None
 1.13A 5vooB-1h4yA:
2.5		 5vooB-1h4yA:
18.88