SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		5 / 12 LEU A 197
GLY A  18
GLY A  19
ASN A  20
THR A 147
 None
NAP  A 263 ( 3.9A)
None
NAP  A 263 (-3.6A)
NAP  A 263 ( 4.5A)
 1.16A 1likA-1h5qA:
6.3		 1likA-1h5qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		5 / 12 TYR A 169
ILE A  23
ALA A 174
SER A 172
GLY A 200
 NAP  A 263 (-4.4A)
NAP  A 263 (-4.3A)
None
None
None
 1.12A 1nbiA-1h5qA:
6.9		 1nbiA-1h5qA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		5 / 12 TYR A 169
ILE A  23
ALA A 174
SER A 172
GLY A 200
 NAP  A 263 (-4.4A)
NAP  A 263 (-4.3A)
None
None
None
 1.12A 1nbiB-1h5qA:
6.9		 1nbiB-1h5qA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		5 / 12 TYR A 169
THR A 147
ALA A 174
SER A 172
GLY A 200
 NAP  A 263 (-4.4A)
NAP  A 263 ( 4.5A)
None
None
None
 1.29A 1nbiC-1h5qA:
6.8		 1nbiC-1h5qA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		5 / 12 TYR A 169
THR A 147
ALA A 174
SER A 172
GLY A 200
 NAP  A 263 (-4.4A)
NAP  A 263 ( 4.5A)
None
None
None
 1.28A 1nbiD-1h5qA:
6.9		 1nbiD-1h5qA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		5 / 12 LEU A 241
GLY A  35
ALA A  34
ALA A 237
ILE A 238
 None
 0.86A 1rl8B-1h5qA:
undetectable		 1rl8B-1h5qA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		4 / 7 TYR A 169
THR A 207
THR A 204
MET A 150
 NAP  A 263 (-4.4A)
None
NAP  A 263 ( 3.9A)
None
 1.15A 1tv8A-1h5qA:
2.5		 1tv8A-1h5qA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		6 / 11 GLY A  18
ASP A  69
VAL A  70
ALA A  97
VAL A  99
VAL A 119
 NAP  A 263 ( 3.9A)
NAP  A 263 (-3.5A)
NAP  A 263 (-3.7A)
NAP  A 263 (-3.6A)
None
NAP  A 263 (-4.2A)
 0.45A 1uayA-1h5qA:
29.1		 1uayA-1h5qA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		6 / 10 GLY A  18
ASP A  69
VAL A  70
ALA A  97
VAL A  99
VAL A 119
 NAP  A 263 ( 3.9A)
NAP  A 263 (-3.5A)
NAP  A 263 (-3.7A)
NAP  A 263 (-3.6A)
None
NAP  A 263 (-4.2A)
 0.41A 1uayB-1h5qA:
29.6		 1uayB-1h5qA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		3 / 3 ASN A 221
TRP A 262
GLN A 157
 None
 0.86A 1xoqA-1h5qA:
undetectable		 1xoqA-1h5qA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		4 / 8 TYR A 169
THR A 207
THR A 204
MET A 150
 NAP  A 263 (-4.4A)
None
NAP  A 263 ( 3.9A)
None
 1.12A 2fb2A-1h5qA:
2.3		 2fb2A-1h5qA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		4 / 7 TYR A 169
THR A 207
THR A 204
MET A 150
 NAP  A 263 (-4.4A)
None
NAP  A 263 ( 3.9A)
None
 1.06A 2fb2B-1h5qA:
2.3		 2fb2B-1h5qA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		5 / 12 LEU A  87
GLY A  56
PHE A  59
VAL A  40
ALA A  65
 None
 1.36A 2kceA-1h5qA:
0.0		 2kceA-1h5qA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		4 / 5 VAL A  55
THR A  52
VAL A  40
GLY A  19
 None
 1.14A 2p2fA-1h5qA:
2.6		 2p2fA-1h5qA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		4 / 4 VAL A  55
THR A  52
VAL A  40
GLY A  19
 None
 1.16A 2p2fB-1h5qA:
5.6		 2p2fB-1h5qA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		5 / 10 LEU A 136
ILE A 192
SER A  91
LYS A 141
GLY A 142
 None
 1.30A 3ik6B-1h5qA:
0.2
3ik6E-1h5qA:
0.5		 3ik6B-1h5qA:
20.29
3ik6E-1h5qA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		5 / 11 ILE A 192
SER A  91
LYS A 141
GLY A 142
LEU A 136
 None
 1.33A 3iluB-1h5qA:
0.5
3iluE-1h5qA:
0.3		 3iluB-1h5qA:
20.29
3iluE-1h5qA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		4 / 5 TYR A 169
VAL A 116
SER A 100
GLY A  98
 NAP  A 263 (-4.4A)
None
None
NAP  A 263 (-3.3A)
 1.23A 3v4tA-1h5qA:
0.0
3v4tD-1h5qA:
1.0		 3v4tA-1h5qA:
22.89
3v4tD-1h5qA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		4 / 5 GLY A 123
THR A 127
ILE A  75
VAL A  76
 None
 0.88A 3wriA-1h5qA:
undetectable		 3wriA-1h5qA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		4 / 5 GLY A 123
THR A 127
ILE A  75
VAL A  76
 None
 0.89A 3wriB-1h5qA:
undetectable		 3wriB-1h5qA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		4 / 8 ILE A  80
ASP A  84
ILE A  90
GLY A 142
 None
 0.78A 4ac9C-1h5qA:
4.3		 4ac9C-1h5qA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		5 / 12 LEU A 241
ILE A  14
ALA A  95
THR A 127
VAL A 131
 None
 1.09A 4nkxC-1h5qA:
undetectable		 4nkxC-1h5qA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		5 / 12 LEU A 241
ILE A  14
ALA A  95
THR A 127
VAL A 131
 None
 1.04A 4nkxD-1h5qA:
undetectable		 4nkxD-1h5qA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		4 / 7 VAL A 116
PHE A 113
HIS A 110
GLU A 111
 None
 1.27A 5ad9A-1h5qA:
0.0
5ad9B-1h5qA:
0.4		 5ad9A-1h5qA:
19.07
5ad9B-1h5qA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE
(Agaricus
bisporus) 		4 / 7 VAL A  55
GLU A  58
ASN A  96
ILE A  94
 None
None
NAP  A 263 (-3.5A)
None
 0.94A 5jh7C-1h5qA:
6.6		 5jh7C-1h5qA:
21.69