SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
1h5y HISF
(Pyrobaculum
aerophilum)
5 / 12 ILE A  52
LEU A  11
ASP A  67
ALA A  75
VAL A  76
None
1.12A 1jg2A-1h5yA:
undetectable
1jg2A-1h5yA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
1h5y HISF
(Pyrobaculum
aerophilum)
5 / 12 GLY A 206
ASP A 186
ALA A 227
SER A 228
LEU A  53
PO4  A 302 (-3.8A)
None
PO4  A 302 (-3.7A)
PO4  A 302 (-2.6A)
GOL  A 401 ( 4.9A)
1.19A 1kiaD-1h5yA:
0.4
1kiaD-1h5yA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)
1h5y HISF
(Pyrobaculum
aerophilum)
4 / 7 GLU A 164
TRP A 159
PRO A 113
GLY A 167
None
1.08A 2hs1B-1h5yA:
undetectable
2hs1B-1h5yA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)
1h5y HISF
(Pyrobaculum
aerophilum)
3 / 3 GLY A 205
TYR A 185
SER A 204
PO4  A 302 (-3.6A)
None
PO4  A 302 ( 4.5A)
0.71A 2xatA-1h5yA:
0.0
2xatA-1h5yA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)
1h5y HISF
(Pyrobaculum
aerophilum)
5 / 12 PHE A 213
VAL A 240
LEU A 235
ILE A 237
TYR A  42
None
1.36A 3elzA-1h5yA:
undetectable
3elzA-1h5yA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
1h5y HISF
(Pyrobaculum
aerophilum)
4 / 6 ILE A 237
VAL A 240
LEU A 244
LEU A   5
None
0.78A 3kp6A-1h5yA:
undetectable
3kp6B-1h5yA:
undetectable
3kp6A-1h5yA:
21.57
3kp6B-1h5yA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)
1h5y HISF
(Pyrobaculum
aerophilum)
5 / 12 GLY A 167
GLY A 124
LEU A  81
VAL A 130
ALA A 131
None
None
None
None
GOL  A 401 (-3.4A)
1.25A 3t7vA-1h5yA:
14.8
3t7vA-1h5yA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
1h5y HISF
(Pyrobaculum
aerophilum)
4 / 6 GLU A 188
ASP A 186
ASP A 177
ARG A 178
None
1.20A 4kcnA-1h5yA:
undetectable
4kcnA-1h5yA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
1h5y HISF
(Pyrobaculum
aerophilum)
4 / 6 GLU A 188
ASP A 186
ASP A 177
ARG A 178
None
1.22A 4kcnB-1h5yA:
undetectable
4kcnB-1h5yA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)
1h5y HISF
(Pyrobaculum
aerophilum)
5 / 9 ALA A 207
LEU A 225
SER A 236
LEU A 235
VAL A 240
PO4  A 302 ( 4.9A)
None
None
None
None
1.13A 4or0A-1h5yA:
undetectable
4or0A-1h5yA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)
1h5y HISF
(Pyrobaculum
aerophilum)
5 / 9 ALA A 207
LEU A 225
SER A 236
LEU A 235
VAL A 240
PO4  A 302 ( 4.9A)
None
None
None
None
1.16A 4or0B-1h5yA:
undetectable
4or0B-1h5yA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)
1h5y HISF
(Pyrobaculum
aerophilum)
4 / 6 PHE A  65
LEU A  11
PRO A  35
ARG A  62
None
1.38A 4yv5B-1h5yA:
undetectable
4yv5B-1h5yA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)
1h5y HISF
(Pyrobaculum
aerophilum)
4 / 6 PHE A  65
LEU A  11
PRO A  35
ARG A  62
None
1.37A 4yv5A-1h5yA:
undetectable
4yv5A-1h5yA:
14.62