SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h65'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		5 / 12 ILE A 158
LEU A  32
VAL A  37
LEU A  40
ILE A 239
 None
 0.99A 1df7A-1h65A:
undetectable		 1df7A-1h65A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		3 / 3 THR A  21
LEU A  25
LEU A  32
 None
 0.65A 1mz9C-1h65A:
undetectable		 1mz9C-1h65A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		5 / 12 LEU A 124
SER A 182
LEU A 186
LEU A 161
THR A  55
 None
 1.40A 1ya3B-1h65A:
undetectable		 1ya3B-1h65A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		4 / 6 SER A  81
PHE A  87
ASN A  90
ILE A  42
 None
 1.01A 1yc2A-1h65A:
undetectable		 1yc2A-1h65A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		5 / 12 VAL A 141
ILE A 120
ILE A 153
VAL A 252
LEU A 108
 None
 1.27A 2ft9A-1h65A:
0.0		 2ft9A-1h65A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		4 / 7 PHE A  17
LEU A  25
LEU A  26
GLU A  62
 None
 0.92A 2jn3A-1h65A:
undetectable		 2jn3A-1h65A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		4 / 8 ILE A  42
ILE A  14
ASN A  31
ALA A 243
 None
 0.53A 2nniA-1h65A:
0.0		 2nniA-1h65A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		3 / 3 ILE A 158
ILE A  42
LEU A 195
 None
 0.43A 2prgA-1h65A:
0.0		 2prgA-1h65A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		5 / 12 ILE A 209
GLU A 210
HIS A 163
GLY A  49
VAL A 126
 None
GDP  A 281 (-3.2A)
GDP  A 281 (-3.5A)
GDP  A 281 (-3.5A)
None
 1.31A 3rlbB-1h65A:
0.0		 3rlbB-1h65A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		5 / 12 ILE A 158
LEU A  32
VAL A  37
LEU A  40
ILE A 239
 None
 0.79A 4km2B-1h65A:
undetectable		 4km2B-1h65A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		4 / 8 ILE A  91
LEU A  25
LEU A  28
ILE A 239
 None
 0.93A 4xtaB-1h65A:
undetectable		 4xtaB-1h65A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		5 / 12 VAL A  56
PRO A  77
VAL A  65
LEU A 115
ILE A 145
 None
 1.15A 5hv1A-1h65A:
undetectable		 5hv1A-1h65A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		3 / 3 LEU A 185
ALA A 184
LEU A 161
 None
 0.52A 5uunB-1h65A:
undetectable		 5uunB-1h65A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34
(Pisum
sativum) 		4 / 5 ARG A  82
ARG A  84
GLY A  13
ASN A  15
 None
 1.14A 6dwjB-1h65A:
0.0
6dwjD-1h65A:
0.0		 6dwjB-1h65A:
20.98
6dwjD-1h65A:
20.98