SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 1h6g ALPHA-1 CATENIN
(Homo
sapiens) 		5 / 9 LEU A 538
GLU A 592
GLU A 596
ALA A 597
MET A 606
 None
 1.23A 1ctrA-1h6gA:
undetectable		 1ctrA-1h6gA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 1h6g ALPHA-1 CATENIN
(Homo
sapiens) 		5 / 10 GLU A 418
ALA A 420
LEU A 401
LEU A 469
ALA A 408
 None
 1.32A 1ie4A-1h6gA:
undetectable
1ie4C-1h6gA:
undetectable		 1ie4A-1h6gA:
19.74
1ie4C-1h6gA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 1h6g ALPHA-1 CATENIN
(Homo
sapiens) 		5 / 10 LEU A 469
ALA A 408
GLU A 418
ALA A 420
LEU A 401
 None
 1.27A 1ie4A-1h6gA:
undetectable
1ie4C-1h6gA:
undetectable		 1ie4A-1h6gA:
19.74
1ie4C-1h6gA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1h6g ALPHA-1 CATENIN
(Homo
sapiens) 		5 / 12 LEU A 486
ASN A 483
ALA A 467
LEU A 401
LEU A 460
 None
 1.44A 2oaxC-1h6gA:
undetectable		 2oaxC-1h6gA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 1h6g ALPHA-1 CATENIN
(Homo
sapiens) 		5 / 12 LEU A 486
ASN A 483
ALA A 467
LEU A 401
LEU A 460
 None
 1.45A 3vhuA-1h6gA:
undetectable		 3vhuA-1h6gA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1h6g ALPHA-1 CATENIN
(Homo
sapiens) 		3 / 3 ARG A 548
ILE A 519
SER A 515
 None
 0.71A 5zw2A-1h6gA:
3.5		 5zw2A-1h6gA:
18.86