SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 9 VAL A 235
LEU A 226
ILE A 193
ALA A 215
LEU A 237
 None
 0.99A 1eqgA-1h6uA:
undetectable		 1eqgA-1h6uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 11 VAL A 235
LEU A 226
ILE A 193
ALA A 215
LEU A 237
 None
 1.01A 1eqgB-1h6uA:
undetectable		 1eqgB-1h6uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 12 VAL A 235
LEU A 226
ILE A 193
ALA A 215
LEU A 237
 None
 1.03A 1eqhA-1h6uA:
undetectable		 1eqhA-1h6uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 12 VAL A 235
LEU A 226
ILE A 193
ALA A 215
LEU A 237
 None
 1.04A 1eqhB-1h6uA:
undetectable		 1eqhB-1h6uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 12 ILE A 242
VAL A 235
LEU A 248
PHE A 326
PHE A 333
 None
 1.40A 2no0A-1h6uA:
0.0		 2no0A-1h6uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 12 ILE A 242
VAL A 235
LEU A 248
PHE A 326
PHE A 333
 None
 1.39A 2no0B-1h6uA:
undetectable		 2no0B-1h6uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		4 / 7 PHE A 320
VAL A 281
LEU A 305
VAL A 316
 None
 0.86A 3hs6B-1h6uA:
undetectable		 3hs6B-1h6uA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		4 / 8 LEU A 163
SER A 164
LEU A 171
ILE A 144
 None
 0.90A 3ln1A-1h6uA:
undetectable		 3ln1A-1h6uA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		4 / 7 LEU A 163
SER A 164
LEU A 171
ILE A 144
 None
 0.89A 3ln1B-1h6uA:
undetectable		 3ln1B-1h6uA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 12 ALA A 227
LEU A 229
VAL A 235
LEU A 213
ILE A 220
 None
 1.14A 4g1bA-1h6uA:
undetectable		 4g1bA-1h6uA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		4 / 8 LEU A 127
LEU A 141
ILE A 110
VAL A  94
 None
 0.86A 4klaA-1h6uA:
undetectable		 4klaA-1h6uA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 12 LEU A 103
ALA A  83
LEU A  53
ILE A  78
LYS A  58
 None
 1.00A 4o2bB-1h6uA:
undetectable		 4o2bB-1h6uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		6 / 12 LEU A 103
ALA A  83
LEU A  53
ILE A  78
LYS A  58
ALA A  60
 None
 0.94A 4o2bD-1h6uA:
undetectable		 4o2bD-1h6uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 10 LEU A 149
LEU A 103
LEU A 116
LEU A 113
LEU A 160
 None
 1.07A 4odoA-1h6uA:
undetectable		 4odoA-1h6uA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 10 LEU A 149
LEU A 103
LEU A 116
LEU A 113
LEU A 160
 None
 1.07A 4odoB-1h6uA:
undetectable		 4odoB-1h6uA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 10 LEU A 149
LEU A 103
LEU A 116
LEU A 113
LEU A 160
 None
 1.08A 4odoC-1h6uA:
undetectable		 4odoC-1h6uA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		3 / 3 LEU A 185
LEU A 201
ASN A 178
 None
 0.64A 4otwA-1h6uA:
undetectable		 4otwA-1h6uA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 12 LEU A 103
ALA A  83
ILE A  78
LYS A  58
ALA A  60
 None
 0.77A 5eypB-1h6uA:
undetectable		 5eypB-1h6uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 12 LEU A 103
ALA A  83
LEU A  53
ILE A  78
LYS A  58
 None
 0.97A 5itzB-1h6uA:
0.3		 5itzB-1h6uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 12 LEU A 103
ALA A  83
LEU A  53
ILE A  78
LYS A  58
 None
 0.99A 5mioB-1h6uA:
undetectable		 5mioB-1h6uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		6 / 12 LEU A 103
ALA A  83
LEU A  53
ILE A  78
LYS A  58
ALA A  60
 None
 1.07A 5xiwB-1h6uA:
undetectable		 5xiwB-1h6uA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 1h6u INTERNALIN H
(Listeria
monocytogenes) 		5 / 12 ILE A 154
LEU A 173
ASN A 174
ILE A 138
LEU A 147
 None
 1.05A 6dwnC-1h6uA:
undetectable		 6dwnC-1h6uA:
13.77