SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  47
ILE A  41
ALA A  68
LEU A 112
ILE A 109
 None
 1.17A 1bsxA-1h74A:
0.0		 1bsxA-1h74A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  47
ILE A  41
ALA A  68
LEU A 112
ILE A 109
 None
 1.17A 1bsxB-1h74A:
0.0		 1bsxB-1h74A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 112
ASP A  73
GLY A  65
ALA A 108
ILE A 109
 None
 0.75A 1rl8B-1h74A:
undetectable		 1rl8B-1h74A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A 112
GLY A  80
GLY A  65
ILE A  48
ALA A 108
ILE A 109
 None
 1.10A 1rl8B-1h74A:
undetectable		 1rl8B-1h74A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  36
ILE A  83
GLY A  65
ILE A  66
ALA A 103
 None
 0.82A 1sguB-1h74A:
undetectable		 1sguB-1h74A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 CYH A  13
ALA A 145
GLY A 148
GLY A 149
GLY A  88
 None
 0.82A 1sqfA-1h74A:
undetectable		 1sqfA-1h74A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 106
ILE A 109
ILE A  72
ASP A  74
 None
 0.92A 1upfB-1h74A:
undetectable		 1upfB-1h74A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 4 LEU A 170
PRO A  32
ILE A 266
LEU A  27
 None
 1.06A 1ya4C-1h74A:
undetectable		 1ya4C-1h74A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A 112
GLY A  65
ALA A 108
ILE A 109
 None
 0.70A 2aohB-1h74A:
undetectable		 2aohB-1h74A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 7 LEU A 281
GLY A 236
ILE A 258
PRO A 177
ILE A 245
 None
 1.36A 2aojB-1h74A:
undetectable		 2aojB-1h74A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 PRO A  59
THR A  57
PRO A  56
 None
None
ADP  A 400 (-4.8A)
 0.79A 2d55C-1h74A:
undetectable		 2d55C-1h74A:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 6 THR A 183
SER A 134
SER A 133
VAL A  63
 ADP  A 400 ( 3.1A)
ADP  A 400 ( 4.5A)
ADP  A 400 (-3.1A)
ADP  A 400 (-4.0A)
 1.29A 2hdnI-1h74A:
0.0
2hdnJ-1h74A:
undetectable
2hdnL-1h74A:
undetectable		 2hdnI-1h74A:
13.11
2hdnJ-1h74A:
22.13
2hdnL-1h74A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 6 SER A 133
VAL A  63
THR A 183
SER A 134
 ADP  A 400 (-3.1A)
ADP  A 400 (-4.0A)
ADP  A 400 ( 3.1A)
ADP  A 400 ( 4.5A)
 1.30A 2hdnJ-1h74A:
undetectable
2hdnK-1h74A:
0.0
2hdnL-1h74A:
undetectable		 2hdnJ-1h74A:
22.13
2hdnK-1h74A:
13.11
2hdnL-1h74A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 4 LEU A  27
THR A  14
ILE A 164
HIS A 163
 None
 1.14A 2jfaB-1h74A:
0.0		 2jfaB-1h74A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A 112
GLY A  80
GLY A  65
ILE A  48
ALA A 108
ILE A 109
 None
 1.13A 2nmzA-1h74A:
undetectable		 2nmzA-1h74A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A 112
GLY A  80
GLY A  65
ILE A  48
ALA A 108
ILE A 109
 None
 1.16A 2nmzB-1h74A:
undetectable		 2nmzB-1h74A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 258
ARG A 235
PRO A  32
GLY A  96
 None
ILE  A 500 (-3.1A)
None
ADP  A 400 ( 4.0A)
 1.06A 2pnjB-1h74A:
0.0		 2pnjB-1h74A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 112
GLY A  80
GLY A  65
ALA A 108
ILE A 109
 None
 0.91A 2rkfA-1h74A:
undetectable		 2rkfA-1h74A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 112
ASP A  73
GLY A  65
ALA A 108
ILE A 109
 None
 0.75A 2rkfB-1h74A:
undetectable		 2rkfB-1h74A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A 112
GLY A  80
GLY A  65
ILE A  48
ALA A 108
ILE A 109
 None
 1.04A 2rkfB-1h74A:
undetectable		 2rkfB-1h74A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 7 PHE A 150
SER A  15
PHE A 221
ILE A 266
 None
 0.92A 2v0mC-1h74A:
0.0		 2v0mC-1h74A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 170
ILE A 172
PRO A 269
VAL A 203
 None
 1.12A 2ygoA-1h74A:
0.0		 2ygoA-1h74A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  42
THR A  57
GLU A  45
 None
 0.82A 2zifB-1h74A:
undetectable		 2zifB-1h74A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 8 LEU A 112
GLY A  80
GLY A  65
ILE A  48
ILE A 109
 None
 1.18A 3ekpA-1h74A:
undetectable		 3ekpA-1h74A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 112
GLY A  65
ILE A  48
ALA A 108
ILE A 109
 None
 0.95A 3ekpB-1h74A:
undetectable		 3ekpB-1h74A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 112
GLY A  80
GLY A  65
ILE A  48
ILE A 109
 None
 1.02A 3el1A-1h74A:
undetectable		 3el1A-1h74A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 112
GLY A  80
GLY A  65
ILE A  48
ILE A 109
 None
 1.02A 3mwsA-1h74A:
undetectable		 3mwsA-1h74A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 123
SER A 127
LEU A 159
 None
 0.40A 3n8xA-1h74A:
0.0		 3n8xA-1h74A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 112
GLY A  80
GLY A  65
ILE A  48
ILE A 109
 None
 1.04A 3oxcB-1h74A:
undetectable		 3oxcB-1h74A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A  27
GLY A  26
PHE A 150
PHE A 221
 None
 1.00A 3smtA-1h74A:
0.0		 3smtA-1h74A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 231
PHE A  22
GLU A 188
LEU A 238
 None
ILE  A 500 (-4.8A)
None
None
 0.81A 3ua5A-1h74A:
undetectable		 3ua5A-1h74A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 5 SER A  97
ILE A 176
GLY A  88
PRO A  32
 ADP  A 400 (-3.5A)
None
None
None
 1.04A 3uboB-1h74A:
undetectable		 3uboB-1h74A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 8 GLY A 222
GLY A 255
MET A 226
GLY A  19
ILE A 266
 None
 0.99A 3v1nA-1h74A:
undetectable		 3v1nA-1h74A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 224
VAL A  20
SER A 227
GLY A 204
 None
 1.38A 3v4tA-1h74A:
0.0
3v4tD-1h74A:
undetectable		 3v4tA-1h74A:
23.42
3v4tD-1h74A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 6 THR A  14
GLY A  96
ASN A 141
GLY A 104
 None
ADP  A 400 ( 4.0A)
ILE  A 500 (-4.2A)
None
 0.74A 4fjpA-1h74A:
undetectable		 4fjpA-1h74A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 7 THR A  14
GLY A  96
ASN A 141
GLY A 104
 None
ADP  A 400 ( 4.0A)
ILE  A 500 (-4.2A)
None
 0.72A 4forA-1h74A:
undetectable		 4forA-1h74A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 231
ILE A 174
LEU A  29
GLY A  94
ASN A 141
 None
None
None
ADP  A 400 ( 4.5A)
ILE  A 500 (-4.2A)
 0.93A 4o1eB-1h74A:
undetectable		 4o1eB-1h74A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 183
GLY A  96
GLY A  94
GLY A  92
ALA A 145
 ADP  A 400 ( 3.1A)
ADP  A 400 ( 4.0A)
ADP  A 400 ( 4.5A)
ADP  A 400 (-3.7A)
None
 1.00A 4uciA-1h74A:
undetectable		 4uciA-1h74A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 183
GLY A  96
GLY A  94
GLY A  92
ALA A 145
 ADP  A 400 ( 3.1A)
ADP  A 400 ( 4.0A)
ADP  A 400 ( 4.5A)
ADP  A 400 (-3.7A)
None
 1.01A 4uciB-1h74A:
undetectable		 4uciB-1h74A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  16
PHE A  22
THR A 183
LEU A 190
PRO A 191
 ILE  A 500 ( 4.0A)
ILE  A 500 (-4.8A)
ADP  A 400 ( 3.1A)
None
None
 0.94A 5eajB-1h74A:
undetectable		 5eajB-1h74A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 108
ILE A 109
GLY A  65
GLY A 104
VAL A  81
 None
 1.08A 5i6xA-1h74A:
undetectable		 5i6xA-1h74A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A 185
GLY A  92
ALA A  16
ASN A 141
ASN A  17
 None
ADP  A 400 (-3.7A)
ILE  A 500 ( 4.0A)
ILE  A 500 (-4.2A)
ILE  A 500 (-2.8A)
 1.21A 5kbwB-1h74A:
0.2		 5kbwB-1h74A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 6 GLY A 236
ASP A 228
GLY A 262
PRO A 263
GLY A 260
 None
None
None
None
ILE  A 500 ( 4.1A)
 1.35A 6ag0C-1h74A:
undetectable		 6ag0C-1h74A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A  18
GLY A 222
PHE A 168
 None
 0.60A 6exiC-1h74A:
undetectable		 6exiC-1h74A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1h74 HOMOSERINE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A 126
SER A  98
GLY A  96
THR A  14
 None
ADP  A 400 (-3.9A)
ADP  A 400 ( 4.0A)
None
 0.85A 6f8cA-1h74A:
undetectable		 6f8cA-1h74A:
12.50