SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 1h7k CATALASE
(Proteus
mirabilis) 		5 / 12 LEU A 258
MET A 124
ILE A 322
PHE A 201
ILE A 260
 None
 1.48A 1osvB-1h7kA:
0.0		 1osvB-1h7kA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1h7k CATALASE
(Proteus
mirabilis) 		3 / 3 ARG A 333
VAL A 211
GLY A 321
 HEM  A 600 (-3.5A)
None
None
 0.64A 2avvE-1h7kA:
undetectable		 2avvE-1h7kA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 7 GLY A  62
MET A  88
GLN A 219
PHE A  92
 None
 0.96A 2qwxA-1h7kA:
undetectable
2qwxB-1h7kA:
undetectable		 2qwxA-1h7kA:
20.00
2qwxB-1h7kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 7 PHE A  79
ILE A  70
THR A 117
ILE A 262
 None
 0.95A 2v0mB-1h7kA:
0.0		 2v0mB-1h7kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1h7k CATALASE
(Proteus
mirabilis) 		3 / 3 ARG A 182
GLY A 183
SER A 240
 None
 0.60A 2xctB-1h7kA:
undetectable		 2xctB-1h7kA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1h7k CATALASE
(Proteus
mirabilis) 		3 / 3 GLU A 444
ASP A 178
TYR A 133
 None
 0.88A 2yvlB-1h7kA:
undetectable		 2yvlB-1h7kA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 1h7k CATALASE
(Proteus
mirabilis) 		3 / 3 ASN A 223
ASP A 178
GLN A 174
 None
 0.73A 3eeyC-1h7kA:
undetectable		 3eeyC-1h7kA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 1h7k CATALASE
(Proteus
mirabilis) 		3 / 3 ASN A 223
ASP A 178
GLN A 174
 None
 0.73A 3eeyD-1h7kA:
undetectable		 3eeyD-1h7kA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 1h7k CATALASE
(Proteus
mirabilis) 		3 / 3 ASN A 223
ASP A 178
GLN A 174
 None
 0.72A 3eeyE-1h7kA:
undetectable		 3eeyE-1h7kA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NCQ_B_ACTB120_0
(NITROGEN REGULATORY
PROTEIN P-II
(GLNB-2))		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 4 MET A 329
LYS A 328
ASP A 327
ASP A 136
 HEM  A 600 (-4.4A)
None
None
None
 1.19A 3ncqB-1h7kA:
0.0		 3ncqB-1h7kA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 8 PHE A  64
GLY A 293
LEU A 258
ILE A  70
 None
 0.82A 4em2A-1h7kA:
undetectable		 4em2A-1h7kA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 4 SER A 336
LEU A 330
TYR A 337
PRO A 141
 HEM  A 600 (-3.5A)
None
HEM  A 600 (-3.8A)
None
 1.50A 4jksA-1h7kA:
0.0		 4jksA-1h7kA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 4 SER A 336
LEU A 330
TYR A 337
PRO A 141
 HEM  A 600 (-3.5A)
None
HEM  A 600 (-3.8A)
None
 1.48A 4jksB-1h7kA:
0.0		 4jksB-1h7kA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 4 SER A 336
LEU A 330
TYR A 337
PRO A 141
 HEM  A 600 (-3.5A)
None
HEM  A 600 (-3.8A)
None
 1.49A 4jkuA-1h7kA:
0.0		 4jkuA-1h7kA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_2
(SUGAR KINASE)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 4 SER A 336
LEU A 330
TYR A 337
PRO A 141
 HEM  A 600 (-3.5A)
None
HEM  A 600 (-3.8A)
None
 1.50A 4k8kA-1h7kA:
0.0		 4k8kA-1h7kA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_2
(SUGAR KINASE)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 4 SER A 336
LEU A 330
TYR A 337
PRO A 141
 HEM  A 600 (-3.5A)
None
HEM  A 600 (-3.8A)
None
 1.50A 4k8kB-1h7kA:
0.0		 4k8kB-1h7kA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 4 SER A 336
LEU A 330
TYR A 337
PRO A 141
 HEM  A 600 (-3.5A)
None
HEM  A 600 (-3.8A)
None
 1.50A 4kalA-1h7kA:
0.0		 4kalA-1h7kA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 4 SER A 336
LEU A 330
TYR A 337
PRO A 141
 HEM  A 600 (-3.5A)
None
HEM  A 600 (-3.8A)
None
 1.48A 4kalB-1h7kA:
undetectable		 4kalB-1h7kA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 6 GLU A 416
ARG A 413
ASP A 415
ARG A 135
 None
 1.35A 4kcnA-1h7kA:
undetectable		 4kcnA-1h7kA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 6 GLU A 416
ARG A 413
ASP A 415
ARG A 135
 None
 1.37A 4kcnB-1h7kA:
undetectable		 4kcnB-1h7kA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 6 GLY A 126
ASP A 123
PRO A 315
ARG A 333
 HEM  A 600 (-3.8A)
None
None
HEM  A 600 (-3.5A)
 1.08A 4lajA-1h7kA:
undetectable
4lajB-1h7kA:
undetectable		 4lajA-1h7kA:
19.08
4lajB-1h7kA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 6 GLY A 195
ASP A 123
PRO A 315
ARG A 333
 None
None
None
HEM  A 600 (-3.5A)
 1.01A 4lajA-1h7kA:
undetectable
4lajB-1h7kA:
undetectable		 4lajA-1h7kA:
19.08
4lajB-1h7kA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 4 SER A 336
LEU A 330
TYR A 337
PRO A 141
 HEM  A 600 (-3.5A)
None
HEM  A 600 (-3.8A)
None
 1.50A 4lcaB-1h7kA:
0.0		 4lcaB-1h7kA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1h7k CATALASE
(Proteus
mirabilis) 		5 / 11 MET A 437
LEU A 429
LEU A 425
PRO A 130
VAL A 131
 None
 1.45A 4mk4B-1h7kA:
undetectable		 4mk4B-1h7kA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 1h7k CATALASE
(Proteus
mirabilis) 		5 / 10 VAL A 211
TYR A 199
GLY A 321
PHE A 201
SER A 325
 None
 1.30A 4mmdA-1h7kA:
2.3		 4mmdA-1h7kA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 1h7k CATALASE
(Proteus
mirabilis) 		5 / 12 LEU A 297
GLY A 110
ASN A 127
ALA A  90
GLY A 195
 None
HEM  A 600 (-3.6A)
HEM  A 600 (-3.3A)
None
None
 1.17A 4n09A-1h7kA:
undetectable		 4n09A-1h7kA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 5 ARG A 152
THR A 153
ASP A 150
TYR A 160
 None
 1.47A 4oltA-1h7kA:
0.0		 4oltA-1h7kA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 5 ARG A 152
THR A 153
ASP A 150
TYR A 160
 None
 1.47A 4oltB-1h7kA:
0.0		 4oltB-1h7kA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 5 ARG A 152
THR A 153
ASP A 150
TYR A 160
 None
 1.47A 4qwpA-1h7kA:
0.0		 4qwpA-1h7kA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 5 ARG A 152
THR A 153
ASP A 150
TYR A 160
 None
 1.48A 4qwpB-1h7kA:
0.0		 4qwpB-1h7kA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 8 GLY A 100
GLU A  98
GLU A 105
ALA A 104
 None
 0.84A 4rjdA-1h7kA:
undetectable
4rjdB-1h7kA:
0.0		 4rjdA-1h7kA:
10.50
4rjdB-1h7kA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1h7k CATALASE
(Proteus
mirabilis) 		4 / 8 TYR A 337
ASP A 327
VAL A 125
GLY A 126
 HEM  A 600 (-3.8A)
None
HEM  A 600 (-4.9A)
HEM  A 600 (-3.8A)
 0.98A 5nzyA-1h7kA:
undetectable		 5nzyA-1h7kA:
20.49