SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.73A 1a7yA-1h7wA:
undetectable		 1a7yA-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 555
PRO A 553
THR A 554
 None
 0.86A 1a7yB-1h7wA:
undetectable		 1a7yB-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.83A 1a7yB-1h7wA:
undetectable		 1a7yB-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 ALA A 563
GLY A 567
TRP A 568
LEU A 540
LEU A 791
 None
 1.01A 1ej0A-1h7wA:
2.8		 1ej0A-1h7wA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 ILE A 435
CYH A 347
ALA A 351
ALA A 348
ALA A 356
 None
 1.07A 1fbyA-1h7wA:
undetectable		 1fbyA-1h7wA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 ILE A 435
CYH A 347
ALA A 351
ALA A 348
ALA A 356
 None
 1.08A 1fbyB-1h7wA:
undetectable		 1fbyB-1h7wA:
13.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		6 / 6 ASN A 609
ILE A 613
ASN A 668
SER A 670
ASN A 736
THR A 737
 FMN  A1030 (-3.7A)
None
FMN  A1030 (-4.0A)
None
FMN  A1030 (-3.6A)
FMN  A1030 ( 4.4A)
 0.20A 1h7xA-1h7wA:
59.2		 1h7xA-1h7wA:
99.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		6 / 6 ASN A 609
ILE A 613
ASN A 668
SER A 670
ASN A 736
THR A 737
 FMN  A1030 (-3.7A)
None
FMN  A1030 (-4.0A)
None
FMN  A1030 (-3.6A)
FMN  A1030 ( 4.4A)
 0.23A 1h7xB-1h7wA:
60.4		 1h7xB-1h7wA:
99.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		6 / 6 ASN A 609
ILE A 613
ASN A 668
SER A 670
ASN A 736
THR A 737
 FMN  A1030 (-3.7A)
None
FMN  A1030 (-4.0A)
None
FMN  A1030 (-3.6A)
FMN  A1030 ( 4.4A)
 0.22A 1h7xC-1h7wA:
58.2		 1h7xC-1h7wA:
99.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		6 / 6 ASN A 609
ILE A 613
ASN A 668
SER A 670
ASN A 736
THR A 737
 FMN  A1030 (-3.7A)
None
FMN  A1030 (-4.0A)
None
FMN  A1030 (-3.6A)
FMN  A1030 ( 4.4A)
 0.23A 1h7xD-1h7wA:
58.5		 1h7xD-1h7wA:
99.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 555
PRO A 553
THR A 554
 None
 0.74A 1i3wE-1h7wA:
undetectable		 1i3wE-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.79A 1i3wE-1h7wA:
undetectable		 1i3wE-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.72A 1i3wF-1h7wA:
undetectable		 1i3wF-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 555
PRO A 553
THR A 554
 None
 0.78A 1i3wG-1h7wA:
undetectable		 1i3wG-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.78A 1i3wG-1h7wA:
undetectable		 1i3wG-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.80A 1i3wH-1h7wA:
undetectable		 1i3wH-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 11 SER A 103
ASN A 106
GLY A 833
THR A 832
GLN A 828
 None
 1.27A 1jr1A-1h7wA:
18.8		 1jr1A-1h7wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 555
PRO A 553
THR A 554
 None
 0.76A 1mnvD-1h7wA:
undetectable		 1mnvD-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.69A 1mnvD-1h7wA:
undetectable		 1mnvD-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 9 ALA A 159
TYR A 109
LEU A 155
GLY A 154
GLY A  71
 None
 1.38A 1ncwH-1h7wA:
0.0
1ncwL-1h7wA:
0.0		 1ncwH-1h7wA:
13.21
1ncwL-1h7wA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 555
PRO A 553
THR A 554
 None
 0.79A 1ovfB-1h7wA:
undetectable		 1ovfB-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 PHE A 234
PHE A 387
LEU A 361
VAL A 337
ALA A 351
 None
 1.28A 1q23A-1h7wA:
0.0
1q23B-1h7wA:
0.0		 1q23A-1h7wA:
11.35
1q23B-1h7wA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 PHE A 234
PHE A 387
LEU A 361
VAL A 337
ALA A 351
 None
 1.25A 1q23D-1h7wA:
0.0
1q23E-1h7wA:
0.0		 1q23D-1h7wA:
11.35
1q23E-1h7wA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.71A 1qfiA-1h7wA:
undetectable		 1qfiA-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.87A 1qfiB-1h7wA:
undetectable		 1qfiB-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 9 ALA A 159
TYR A 109
LEU A 155
GLY A 154
GLY A  71
 None
 1.37A 1ru9H-1h7wA:
0.0
1ru9L-1h7wA:
0.0		 1ru9H-1h7wA:
13.21
1ru9L-1h7wA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 8 GLU A 161
VAL A 240
ARG A 867
ASP A 239
 None
 1.22A 1s3zA-1h7wA:
0.7
1s3zB-1h7wA:
undetectable		 1s3zA-1h7wA:
10.34
1s3zB-1h7wA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 ASP A 250
PHE A 117
ASN A 167
 None
 0.65A 1sg9B-1h7wA:
3.8		 1sg9B-1h7wA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 555
PRO A 553
THR A 554
 None
 0.79A 1unjF-1h7wA:
undetectable		 1unjF-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.74A 1unjF-1h7wA:
undetectable		 1unjF-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 555
PRO A 553
THR A 554
 None
 0.84A 1unjL-1h7wA:
undetectable		 1unjL-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.81A 1unjL-1h7wA:
undetectable		 1unjL-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 555
PRO A 553
THR A 554
 None
 0.83A 1unjR-1h7wA:
undetectable		 1unjR-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.77A 1unjR-1h7wA:
undetectable		 1unjR-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 555
PRO A 553
THR A 554
 None
 0.82A 1unjX-1h7wA:
undetectable		 1unjX-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.80A 1unjX-1h7wA:
undetectable		 1unjX-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.83A 1unmE-1h7wA:
undetectable		 1unmE-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 555
PRO A 553
THR A 554
 None
 0.81A 1unmF-1h7wA:
undetectable		 1unmF-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 554
THR A 555
PRO A 553
 None
 0.77A 1unmF-1h7wA:
undetectable		 1unmF-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 5 GLY A 127
GLN A 157
VAL A 240
SER A 160
 SF4  A1026 ( 4.2A)
None
None
None
 1.23A 1zzuA-1h7wA:
0.0		 1zzuA-1h7wA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 8 SER A 558
SER A 556
SER A 557
LYS A 616
 None
 1.13A 2cmlD-1h7wA:
undetectable		 2cmlD-1h7wA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		6 / 12 GLY A 802
GLY A 926
GLY A 809
ILE A 790
VAL A 535
ILE A 921
 None
 1.12A 2fxeA-1h7wA:
undetectable		 2fxeA-1h7wA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 GLU A 383
ARG A 235
ARG A 353
GLU A 382
ALA A 372
 None
FAD  A1031 (-2.8A)
None
None
None
 1.45A 2htqA-1h7wA:
undetectable		 2htqA-1h7wA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 5 LEU A 540
ASP A 730
ALA A 538
ILE A 638
 None
 1.13A 2qhfA-1h7wA:
0.0		 2qhfA-1h7wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 ALA A  72
ILE A 101
GLY A 153
ALA A 112
ILE A 104
 None
None
SF4  A1026 ( 3.9A)
None
None
 0.85A 2rkfA-1h7wA:
undetectable		 2rkfA-1h7wA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 ALA A  72
ILE A 101
GLY A 153
ALA A 112
ILE A 104
 None
None
SF4  A1026 ( 3.9A)
None
None
 0.85A 2rkfB-1h7wA:
undetectable		 2rkfB-1h7wA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 11 ALA A 198
SER A 199
GLY A 284
ILE A 482
VAL A 464
 FAD  A1031 (-3.4A)
None
FAD  A1031 (-3.6A)
None
None
 1.27A 2uxpB-1h7wA:
0.0		 2uxpB-1h7wA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 VAL A 765
GLY A 794
VAL A 738
GLY A 767
SER A 605
 None
FMN  A1030 (-3.5A)
None
FMN  A1030 (-3.5A)
None
 0.91A 2v0zC-1h7wA:
undetectable		 2v0zC-1h7wA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 8 ILE A 796
GLY A 802
LEU A 806
PHE A 570
 None
 0.81A 2vctA-1h7wA:
1.2		 2vctA-1h7wA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 8 ILE A 796
GLY A 802
LEU A 806
PHE A 570
 None
 0.73A 2vctB-1h7wA:
1.2		 2vctB-1h7wA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 GLY A 496
GLY A 194
GLY A 196
SER A 201
ILE A 283
 None
FAD  A1031 (-3.1A)
FAD  A1031 (-3.4A)
None
FAD  A1031 (-3.7A)
 0.78A 2wa2A-1h7wA:
3.5		 2wa2A-1h7wA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 7 LEU A 665
ALA A 659
GLY A 661
PHE A 707
 None
 0.96A 2wq5A-1h7wA:
0.0		 2wq5A-1h7wA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 ARG A 678
GLY A 679
SER A 719
 None
 0.62A 2xctB-1h7wA:
undetectable		 2xctB-1h7wA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 10 VAL A 535
LEU A 837
LEU A 806
GLY A 802
ALA A 799
 None
 1.26A 2xf3A-1h7wA:
0.0		 2xf3A-1h7wA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 8 PHE A 564
GLY A 567
ILE A 543
PHE A 542
 None
 0.88A 3aodA-1h7wA:
0.0		 3aodA-1h7wA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 ALA A 486
GLY A 284
THR A 228
VAL A 241
ILE A 200
 None
FAD  A1031 (-3.6A)
None
None
None
 1.02A 3c6gA-1h7wA:
undetectable		 3c6gA-1h7wA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 PHE A 805
ALA A 549
ALA A 734
VAL A 778
VAL A 826
 None
FMN  A1030 (-3.3A)
None
None
None
 1.14A 3c6gB-1h7wA:
0.0		 3c6gB-1h7wA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 PHE A 805
ALA A 549
ALA A 734
VAL A 778
VAL A 826
 None
FMN  A1030 (-3.3A)
None
None
None
 1.14A 3czhB-1h7wA:
0.0		 3czhB-1h7wA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 LEU A  67
GLY A 154
PHE A 158
ALA A  76
LEU A 142
 None
None
None
None
SF4  A1027 (-4.0A)
 1.09A 3dh0B-1h7wA:
3.2		 3dh0B-1h7wA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 10 ALA A  72
ILE A 150
GLY A 153
ALA A 112
ILE A 104
 None
SF4  A1027 (-3.8A)
SF4  A1026 ( 3.9A)
None
None
 0.98A 3ekwA-1h7wA:
undetectable		 3ekwA-1h7wA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 6 ILE A 796
THR A 733
LYS A 709
PHE A 570
 None
None
FMN  A1030 (-2.6A)
None
 1.00A 3elzB-1h7wA:
0.0		 3elzB-1h7wA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 5 PRO A 237
VAL A 240
THR A 132
GLY A 153
 None
None
SF4  A1026 ( 4.8A)
SF4  A1026 ( 3.9A)
 0.96A 3elzB-1h7wA:
0.0		 3elzB-1h7wA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 8 GLY A 809
ALA A 810
GLY A 802
LEU A 803
VAL A 535
 None
 1.09A 3em6A-1h7wA:
undetectable		 3em6A-1h7wA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 6 PHE A 387
CYH A 385
THR A 349
PHE A 345
 None
 1.37A 3ltwA-1h7wA:
undetectable		 3ltwA-1h7wA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 8 GLY A 547
ILE A 543
ASP A 663
THR A 573
 None
 0.82A 3pwwA-1h7wA:
undetectable		 3pwwA-1h7wA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 8 ALA A 836
GLY A 833
THR A 832
GLN A 852
 None
 0.92A 3rglA-1h7wA:
undetectable		 3rglA-1h7wA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 PHE A 100
SER A 160
GLN A 156
 None
None
SF4  A1026 (-2.4A)
 0.73A 3smtA-1h7wA:
0.0		 3smtA-1h7wA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 11 GLY A 480
GLY A 284
ILE A 281
ASP A 481
PRO A 197
 FAD  A1031 (-3.4A)
FAD  A1031 (-3.6A)
None
FAD  A1031 (-3.0A)
FAD  A1031 (-3.7A)
 1.10A 4dcmA-1h7wA:
3.2		 4dcmA-1h7wA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 555
PRO A 553
THR A 554
 None
 0.83A 4hivD-1h7wA:
undetectable		 4hivD-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 9 PHE A 706
CYH A 695
PHE A 788
ILE A 720
 None
 1.18A 4jvlA-1h7wA:
0.0		 4jvlA-1h7wA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 ALA A 198
LEU A 261
GLY A 484
LEU A 442
PHE A 456
 FAD  A1031 (-3.4A)
FAD  A1031 (-4.5A)
None
None
None
 1.06A 4kykA-1h7wA:
0.0
4kykB-1h7wA:
0.0		 4kykA-1h7wA:
11.31
4kykB-1h7wA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 LEU A 572
CYH A 816
ALA A 549
ASN A 609
GLY A 764
 None
FMN  A1030 (-3.8A)
FMN  A1030 (-3.3A)
FMN  A1030 (-3.7A)
None
 1.12A 4n09A-1h7wA:
4.9		 4n09A-1h7wA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 8 ILE A 116
PHE A 100
THR A  66
THR A  65
 None
 0.86A 4n16A-1h7wA:
undetectable		 4n16A-1h7wA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 5 LEU A 897
ASP A  60
GLU A  56
VAL A 313
 None
 1.19A 4nkvA-1h7wA:
0.0		 4nkvA-1h7wA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 8 SER A 492
SER A 227
GLU A 376
ASP A 342
 FAD  A1031 (-3.2A)
FAD  A1031 ( 4.6A)
None
FAD  A1031 (-4.3A)
 1.31A 4qb9D-1h7wA:
0.0		 4qb9D-1h7wA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_ACTA502_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 4 LYS A  42
ARG A  43
GLY A 880
ASP A  46
 None
 1.42A 4ryaA-1h7wA:
0.0		 4ryaA-1h7wA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 SER A  14
ALA A  10
VAL A   9
 None
 0.65A 4x20C-1h7wA:
2.0		 4x20C-1h7wA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 6 ILE A 636
VAL A 625
PHE A 564
THR A 554
 None
 0.98A 4xe5A-1h7wA:
undetectable		 4xe5A-1h7wA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 GLY A 833
TYR A 830
SER A 103
ILE A 533
ASN A 544
 None
 1.32A 4xueB-1h7wA:
3.1		 4xueB-1h7wA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 10 ASP A 716
VAL A 714
LEU A 710
THR A 735
ALA A 734
 None
 1.35A 4yhaB-1h7wA:
undetectable		 4yhaB-1h7wA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 10 ASP A 716
VAL A 714
LEU A 710
THR A 735
ALA A 734
 None
 1.33A 4yhaF-1h7wA:
undetectable		 4yhaF-1h7wA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 6 LEU A 834
ASN A 544
PRO A 545
ARG A 771
 None
 1.34A 4yv5B-1h7wA:
0.0		 4yv5B-1h7wA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 6 LEU A 834
ASN A 544
PRO A 545
ARG A 771
 None
 1.34A 4yv5A-1h7wA:
0.0		 4yv5A-1h7wA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 6 ILE A 610
ALA A 753
THR A 760
VAL A 754
VAL A 591
 None
 1.37A 5eclD-1h7wA:
0.0		 5eclD-1h7wA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 5 TYR A 211
SER A 187
ALA A 185
GLN A 510
 None
 1.29A 5n0tA-1h7wA:
undetectable		 5n0tA-1h7wA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 9 LEU A 285
VAL A 483
LEU A 461
LEU A 226
ALA A 478
 None
None
None
FAD  A1031 (-3.8A)
None
 1.37A 5og9A-1h7wA:
0.3		 5og9A-1h7wA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 TRP A 697
MET A 651
ASN A 648
 None
 1.30A 5uc1B-1h7wA:
0.0		 5uc1B-1h7wA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 TRP A 697
MET A 651
ASN A 648
 None
 1.32A 5uc1A-1h7wA:
0.0		 5uc1A-1h7wA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 7 LEU A 176
VAL A 515
GLU A 520
SER A 516
 None
 1.33A 5umwA-1h7wA:
0.0
5umwF-1h7wA:
0.0		 5umwA-1h7wA:
5.56
5umwF-1h7wA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 ARG A 722
PHE A 707
LEU A 710
 None
 0.85A 5veuA-1h7wA:
undetectable		 5veuA-1h7wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 7 LEU A 122
LEU A 521
ILE A 200
GLY A 196
ILE A 503
 None
None
None
FAD  A1031 (-3.4A)
None
 1.38A 5vkqA-1h7wA:
undetectable
5vkqB-1h7wA:
undetectable		 5vkqA-1h7wA:
21.18
5vkqB-1h7wA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 PHE A 309
ASN A  57
LEU A 328
GLY A 355
ALA A 356
 None
 1.41A 5x23A-1h7wA:
0.0		 5x23A-1h7wA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 GLY A 794
ASN A 736
ALA A 792
ALA A 774
ALA A 777
 FMN  A1030 (-3.5A)
FMN  A1030 (-3.6A)
None
None
None
 1.05A 5zw4A-1h7wA:
undetectable		 5zw4A-1h7wA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 GLN A 852
TYR A 110
ASN A 108
 None
 1.08A 6dwdC-1h7wA:
0.0		 6dwdC-1h7wA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		4 / 5 GLU A 244
VAL A 241
LEU A 236
THR A 489
 None
None
None
FAD  A1031 (-4.2A)
 1.45A 6dyoA-1h7wA:
0.3		 6dyoA-1h7wA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 ASP A 974
LEU A 979
ARG A  43
 None
 0.77A 7dfrA-1h7wA:
undetectable		 7dfrA-1h7wA:
9.77